BMC Seminar - Role of ALKBH3 in the regulation of DNA DSB repair
Læknagarður
room 201
BMC Seminar Thursday 4th of April at 12:00 in room 201 Læknagarður
Speaker: Dr. Þorkell Guðjónsson, senior scientis at Cancer Research Laboratory, Faculty of Medicine, Sturlugata 8, Reykjavik.
Title: The role of ALKBH3 in the regulation of DNA double strand break repair
Abstract: From the thousands of DNA lesions encountered daily by the human genome, DNA double strand breaks (DSBs) are considered to be the most cytotoxic. Unrepaired or incorrectly repaired DSB have the potential to alter the content and organization of the genome, which can have life-threatening consequences. ALKBH3 is a dioxygenase with a well-described function in DNA alkylation repair and RNA demethylation. In our previous work we showed clinically relevant epigenetic silencing of ALKBH3 in breast cancer suggesting potential tumor suppressive function.