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Forsíða

Forsíða

Pétur Orri Heiðarsson - Professor

Pétur Orri Heiðarsson

–

School of Engineering and Natural Sciences

Pétur Orri Heiðarsson

Professor

Professor

Location
Askja / N-346
Phone
5254276 8951508
Email
pheidarsson [at] hi.is

Unit
Faculty of Life and Environmental Sciences
Website
https://heidarsson.hi.is/

Published works

2024

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2Nature Communications
Novel mechanisms of MITF regulation identified in a mouse suppressor screenEMBO Reports
PED in 2024Nucleic Acids Research

2023

Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding ProcessJournal of the American Chemical Society
Author Correction: Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexesNature Communications
Multifunctional Intrinsically Disordered Regions in Transcription FactorsChemistry - A European Journal

2022

Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered proteinNature Chemistry

2021

From folding to functionEssays in Biochemistry
Protein intrinsic disorder on a dynamic nucleosomal landscape
Disorder in a two-domain neuronal Ca²⁺-binding protein regulates domain stability and dynamics using ligand mimicryCellular and Molecular Life Sciences

2020

Binding without folding – the biomolecular function of disordered polyelectrolyte complexesCurrent Opinion in Structural Biology
Effects of Ligand Binding on the Energy Landscape of Acyl-CoA-Binding ProteinBiophysical Journal
Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexesNature Communications

2018

Extreme disorder in an ultrahigh-affinity protein complexNature
The complex conformational dynamics of neuronal calcium sensor-1Frontiers in Molecular Neuroscience

2015

Single-Molecule Folding Mechanisms of the apo- and Mg²⁺-Bound States of Human Neuronal Calcium Sensor-1Biophysical Journal

2014

Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1Proceedings of the National Academy of Sciences of the United States of America
Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligandsJournal of Biological Chemistry
Exploring the minimally frustrated energy landscape of unfolded ACBPJournal of Molecular Biology

2013

Single-molecule folding mechanism of an EF-hand neuronal calcium sensorStructure
Conformational dynamics of single protein molecules studied by direct mechanical manipulation
Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2Nucleic Acids Research

2012

The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺-activated stateJournal of Molecular Biology
Exploring folding pathways of single proteins using mechanical manipulation
A highly compliant protein native state with a spontaneous-like mechanical unfolding pathwayJournal of the American Chemical Society

2009

Effect of active site mutation on catalysis and backbone dynamics in a cold-adapted enzymeRAUST - Tímarit um raunvísindi og stærðfræði
Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopyFEBS Journal
Áhrif stökkbreytinga í hvarfstöð á hvötunarvirkni og staðbundinn hreyfanleika í stofnkeðju kuldavirks ensímsRAUST - Tímarit um raunvísindi og stærðfræði

2007

Measuring backbone dynamics in proteins using EPR spectroscopy

2006

Aðferðir til að mæla hreyfanleika í próteinum

Keywords for Specialisation:

Single-molecule spectroscopy

Intrinsically disordered proteins

Nucleic acids chemistry

Protein chemistry

Protein structure

Chromatin biophysics