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Forsíða

Forsíða

Pétur Orri Heiðarsson - Professor

Pétur Orri Heiðarsson

–

School of Engineering and Natural Sciences

Pétur Orri Heiðarsson

Professor

Professor

Location
Askja / N-346
Phone
5254276 8951508
Email
pheidarsson [at] hi.is

Unit
Faculty of Life and Environmental Sciences
Website
https://heidarsson.hi.is/

Published works

2024

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2Nature Communications
PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins.Nucleic acids research

2023

Human Small Heat Shock Protein B8 Inhibits Protein Aggregation without Affecting the Native Folding Process.Journal of the American Chemical Society
DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2
Author Correction: Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexesNature Communications
Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen
Multifunctional Intrinsically Disordered Regions in Transcription FactorsChemistry – A European Journal
Frontispiece: Multifunctional Intrinsically Disordered Regions in Transcription FactorsChemistry – A European Journal

2022

Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered proteinNature Chemistry

2021

From folding to function: complex macromolecular reactions unraveled one-by-one with optical tweezersEssays in Biochemistry
Protein intrinsic disorder on a dynamic nucleosomal landscape.Progress in molecular biology and translational science

2020

Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexesNature Communications
Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicryCellular and Molecular Life Sciences
Effects of Ligand Binding on the Energy Landscape of Acyl-CoA-Binding ProteinBiophysical Journal
Disordered Proteins Enable Histone Chaperoning on the Nucleosome

2019

Binding without folding - the biomolecular function of disordered polyelectrolyte complexes.Current opinion in structural biology

2018

Extreme disorder in an ultrahigh-affinity protein complex.Nature
The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective.Frontiers in molecular neuroscience

2015

Single-molecule folding mechanisms of the apo- and Mg(2+)-bound states of human neuronal calcium sensor-1.Biophysical journal

2014

Exploring the Minimally Frustrated Energy Landscape of Unfolded ACBPJournal of Molecular Biology
Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1Proceedings of the National Academy of Sciences
Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.The Journal of biological chemistry

2013

Single-Molecule Folding Mechanism of an EF-Hand Neuronal Calcium SensorStructure
Conformational Dynamics of Single Protein Molecules Studied by Direct Mechanical ManipulationDynamics of Proteins and Nucleic Acids
NMR solution structure of a CRISPR repeat binding protein
Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2Nucleic Acids Research

2012

A Highly Compliant Protein Native State with a Spontaneous-like Mechanical Unfolding PathwayJ. Am. Chem. Soc.
Exploring folding pathways of single proteins using mechanical manipulation
The C-Terminal Tail of Human Neuronal Calcium Sensor 1 Regulates the Conformational Stability of the Ca2+-Activated StateJournal of Molecular Biology

2009

Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopyFEBS Journal

Keywords for Specialisation:

Single-molecule spectroscopy

Intrinsically disordered proteins

Nucleic acids chemistry

Protein chemistry

Protein structure

Chromatin biophysics