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Vilmundur G Guðnason - Professor Emeritus

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School of Health Sciences

Vilmundur G Guðnason

Professor Emeritus

Location
Utan H.Í.
Phone
5351800
Email
vgg [at] hi.is

Unit
Faculty of Medicine
Website
https://scholar.google.com/citations?user=eDkARCwAAAAJ;

Published works

2024

Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and DementiaJAMA network open
Omega-3 Blood Levels and Stroke RiskStroke
Correction toNature Aging
Identification of Distinct Brain MRI Phenotypes and Their Association With Long-Term Dementia Risk in Community-Dwelling Older AdultsNeurology
Cohort ProfileInternational Journal of Epidemiology
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestriesNature Genetics
Refracture and mortality risk in the elderly with osteoporotic fracturesOsteoporosis International
The magnitude and direction of the relationship between risk factor and cognition depends on ageEuropean Journal of Epidemiology
Worldwide trends in underweight and obesity from 1990 to 2022The Lancet
Depression and DementiaAdvances in Alzheimer's Disease
Proteomic analysis of Alzheimer’s disease cerebrospinal fluid reveals alterations associated with APOE ε4 and atomoxetine treatmentScience Translational Medicine
A meta-analysis of previous falls and subsequent fracture risk in cohort studiesOsteoporosis International
A new hip fracture risk index derived from FEA-computed proximal femur fracture loads and energies-to-failureOsteoporosis International
Understanding the genetic complexity of puberty timing across the allele frequency spectrumNature Genetics
Correction toNature Genetics
Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performanceAlzheimer's Research and Therapy
Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s diseaseNature Aging
A genome-wide association meta-analysis of all-cause and vascular dementiaAlzheimer's and Dementia
Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and DementiaNeurology
White matter hyperintensity shape is related to long-term progression of cerebrovascular disease in community-dwelling older adultsJournal of Cerebral Blood Flow and Metabolism
Depressive symptoms score predicts incident type 2 diabetes in community dwelling old Icelandic peopleJournal of Gerontology and Geriatrics
Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular DiseaseCirculation
Male-female spatio-temporal differences of age-related bone changes show faster bone deterioration in older women at femoral regions associated with incident hip fractureJournal of Bone and Mineral Research
Vascular Age Assessed From an Uncalibrated, Noninvasive Pressure Waveform by Using a Deep Learning ApproachHypertension
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutralityNature Communications
Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood PressureKidney International Reports
User Engagement, Acceptability, and Clinical Markers in a Digital Health Program for Nonalcoholic Fatty Liver DiseaseJMIR Cardio
SMIM1 absence is associated with reduced energy expenditure and excess weightMed
Genetic variants for head size share genes and pathways with cancerCell Reports Medicine
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traitsNature Genetics

2023

Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident DementiaBiological Psychiatry Global Open Science
Identification of biomarkers for glycaemic deterioration in type 2 diabetesNature Communications
White matter hyperintensity shape is associated with long-term dementia riskAlzheimer's and Dementia
Dementia prediction in the general population using clinically accessible variablesBMC Medical Informatics and Decision Making
Discordance Between Creatinine-Based and Cystatin C–Based Estimated GFRKidney Medicine
Comparative study of machine learning methods for modeling associations between risk factors and future dementia casesGeroScience
Proteomic prediction of incident heart failure and its main subtypesEuropean Journal of Heart Failure
CKD-EPI and EKFC GFR Estimating EquationsJournal of the American Society of Nephrology : JASN
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid lociFrontiers in Genetics
Identification of circulating proteins associated with general cognitive function among middle-aged and older adultsCommunications Biology
Genetic Risk Score for Intracranial AneurysmsStroke
Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countriesThe Lancet Diabetes and Endocrinology
A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study)Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Author Correction: The power of genetic diversity in genome-wide association studies of lipidsNature
Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementiaGeroScience
Diminishing benefits of urban living for children and adolescents’ growth and developmentNature
Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosisEuropean Heart Journal
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver diseaseNature Genetics
Late-life depression, allostatic load, and risk of dementiaPsychoneuroendocrinology
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcificationNature Genetics
Milk intake and hip fracture incidence in community-dwelling old Icelandic adultsOsteoporosis International
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritizationWellcome Open Research
Previous fracture and subsequent fracture riskOsteoporosis International

2022

Interstitial lung abnormalities are associated with decreased mean telomere lengthThe European respiratory journal
The Proteomic Profile of Interstitial Lung AbnormalitiesAmerican Journal of Respiratory and Critical Care Medicine
Creativity, leisure activities, social engagement and cognitive impairmentAging clinical and experimental research
Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung AbnormalitiesAmerican Journal of Respiratory and Critical Care Medicine
Carotid plaque is strongly associated with coronary artery calcium and predicts incident coronary heart disease in a population-based cohortAtherosclerosis
A saturated map of common genetic variants associated with human heightNature
Fast and robust femur segmentation from computed tomography images for patient-specific hip fracture risk screeningComputer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization
A population-based meta-analysis of circulating GFAP for cognition and dementia riskAnnals of Clinical and Translational Neurology
Social network and the risk for developing mild cognitive impairment and dementia among older adultsAging clinical and experimental research
Association of change in cardiovascular risk factors with incident dementiaAlzheimer's and Dementia
Stroke genetics informs drug discovery and risk prediction across ancestriesNature
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learningMolecular Psychiatry
A proteogenomic signature of age-related macular degeneration in bloodNature Communications
Cognition and brain health among older adults in IcelandGeroScience
Adjusting conventional FRAX estimates of fracture probability according to the number of prior fracturesOsteoporosis International
Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik studyNeurobiology of Aging
Depression and DementiaJournal of Alzheimer's Disease
ErratumNature
Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidateBrain
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individualsNature Genetics
Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab populationNature Communications
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease preventionNature Genetics
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing lossAmerican Journal of Human Genetics
Saturated and Unsaturated Bone Marrow Lipids Have Distinct Effects on Bone Density and Fracture Risk in Older AdultsJournal of Bone and Mineral Research
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysisGenome Biology
Cerebrovascular Risk-Factors of Prevalent and Incident Brain Infarcts in the General PopulationStroke
Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 CohortsDiabetes Care
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individualsCommunications Biology
Mild-to-Moderate Kidney Dysfunction and Cardiovascular DiseaseCirculation
New insights into the genetic etiology of Alzheimer’s disease and related dementiasNature Genetics
APOE epsilon 4 and late-life cognition: mediation by structural brain imaging markersEuropean Journal of Epidemiology
Coding and regulatory variants are associated with serum protein levels and diseaseNature Communications
Finite element derived femoral strength is a better predictor of hip fracture risk than aBMD in the AGES Reykjavik study cohortBone
A joint ventricle and WMH segmentation from MRI for evaluation of healthy and pathological changes in the aging brainPLoS ONE
CorrectionAmerican Journal of Clinical Nutrition
Circulating serum microRNAs including senescent miR-31-5p are associated with incident fragility fractures in older postmenopausal women with type 2 diabetes mellitusBone
PUFA ω-3 and ω-6 biomarkers and sleepAmerican Journal of Clinical Nutrition
Mid- and later-life risk factors for predicting neuropathological brain changes associated with Alzheimer's and vascular dementia: The Honolulu Asia Aging Study and the Age, Gene/Environment Susceptibility-Reykjavik StudyAlzheimer's & dementia : the journal of the Alzheimer's Association
Correction: Association of low-frequency and rare coding variants with information processing speedTranslational Psychiatry
Áhrif menntunar á áhættuþætti og nýgengi æðakölkunarsjúkdómaLæknablaðið
Growth Rate in Childhood and Adolescence and the Risk of Breast and Prostate CancerAmerican Journal of Epidemiology
The relationship between interstitial lung abnormalities, mortality, and multimorbidityThorax
Associations of Pulmonary Function with MRI Brain VolumesJournal of Alzheimer's disease : JAD
A genome-wide association study of serum proteins reveals shared loci with common diseasesNature Communications
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipidsAmerican Journal of Human Genetics
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associationsJournal of Thrombosis and Haemostasis
Update of the fracture risk prediction tool FRAXOsteoporosis International

2021

Dietary patterns in adolescence and risk of colorectal cancerCancer Causes and Control
Body weight changes and longitudinal associations with cognitive decline among community-dwelling older adultsAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
A poor appetite or ability to eat and its association with physical function amongst community-dwelling older adultsEuropean Journal of Ageing
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studiesNature Communications
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweighteLife
Serum 25-Hydroxy-Vitamin D Status and Incident Hip Fractures in Elderly AdultsJournal of Bone and Mineral Research
Genetic insights into biological mechanisms governing human ovarian ageingNature
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressureMolecular Psychiatry
FSH Level and Changes in Bone Mass and Body Composition in Older Women and MenThe Journal of clinical endocrinology and metabolism
Characteristics of incidence hip fracture cases in older adults participating in the longitudinal AGES-Reykjavik studyOsteoporosis International
Overlap of genetic risk between interstitial lung abnormalities and idiopathic pulmonary fibrosisAmerican Journal of Respiratory and Critical Care Medicine
It's in Our BloodTrends in Molecular Medicine
Algengi og nýgengi sykursýki 2 á Íslandi frá 2005 til 2018Læknablaðið
A Noncoding Variant near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects against Myocardial InfarctionJournal of Clinical Endocrinology and Metabolism
Exploratory assessment of pineal gland volume, composition, and urinary 6-sulfatoxymelatonin levels on prostate cancer riskProstate
Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations with Atrial FibrillationCirculation: Genomic and Precision Medicine
Automated femur segmentation from computed tomography images using a deep neural network
Common variants at 12q15 and 12q24 are associated with infant head circumferenceNature Genetics
A proteome-wide genetic investigation identifies several sars-cov-2-exploited host targets of clinical relevanceeLife
Contributions of Cerebral Blood Flow to Associations between Blood Pressure Levels and CognitionHypertension
Copeptin is associated with mortality in elderly peopleEuropean Journal of Clinical Investigation
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals with Type 2 DiabetesCirculation: Genomic and Precision Medicine
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.Nature Communications
A New Panel-Estimated GFR, Including β₂-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse PopulationAmerican Journal of Kidney Diseases
Associations of ω-3 Fatty Acids with Interstitial Lung Disease and Lung Imaging Abnormalities among AdultsAmerican Journal of Epidemiology
Bone density and strength from thoracic and lumbar CT scans both predict incident vertebral fractures independently of fracture locationOsteoporosis International
Publisher CorrectionNature Communications
The trans-ancestral genomic architecture of glycemic traitsNature Genetics
The use of 2-, 5-, and 10-year probabilities to characterize fracture risk after a recent sentinel fractureOsteoporosis International
Type 2 Diabetes, Physical Activity and Risk of Mild CognitiveImpairment and Dementia in Community Dwelling Old Adults
Genome-wide association study of circulating interleukin 6 levels identifies novel lociHuman Molecular Genetics
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019The Lancet
Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortalityEuropean Journal of Radiology Open
Sex-specific 25-hydroxyvitamin D threshold concentrations for functional outcomes in older adultsAmerican Journal of Clinical Nutrition
Serum FSH Is Associated with BMD, Bone Marrow Adiposity, and Body Composition in the AGES-Reykjavik Study of Older AdultsJournal of Clinical Endocrinology and Metabolism
Dementia risk in the general populationEuropean Journal of Epidemiology
Serum levels of ACE2 are higher in patients with obesity and diabetesObesity Science and Practice
New creatinine- And cystatin C-based equations to estimate GFR without raceNew England Journal of Medicine
Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participantsScientific Reports
Computed tomography-based skeletal muscle and adipose tissue attenuationExperimental Gerontology
Publisher CorrectionNature Communications
Diffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndromeScandinavian Journal of Rheumatology
Accelerated decline in quadriceps area and Timed Up and Go test performance are associated with hip fracture risk in older adults with impaired kidney functionExperimental Gerontology
The power of genetic diversity in genome-wide association studies of lipidsNature
The effect on subsequent fracture risk of age, sex, and prior fracture site by recency of prior fractureOsteoporosis International
Wave reflection at the origin of a first-generation branch artery and target organ protectionHypertension
Publisher CorrectionNature Genetics
Association of low-frequency and rare coding variants with information processing speedTranslational Psychiatry
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLDJournal of Hepatology
Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia riskNature Aging
Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarctionHuman Molecular Genetics

2020

GFR in healthy agingJournal of the American Society of Nephrology
A pooled-analysis of age and sex based coronary artery calcium scores percentilesJournal of Cardiovascular Computed Tomography
Cigarette Smoking Is Associated with Lower Quadriceps Cross-sectional Area and Attenuation in Older AdultsNicotine and Tobacco Research
Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure TraitsHGG advances
Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fracturesOsteoporosis International
The genetic architecture of the human cerebral cortexScience (New York, N.Y.)
Hiatus hernia and interstitial lung abnormalitiesEuropean Respiratory Journal
Assessing cardiovascular risks from a mid-thigh CT imageScientific Reports
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territoriesThe Lancet
Common genetic variation indicates separate causes for periventricular and deep white matter hyperintensitiesStroke
The genetics of circulating BDNFBrain Communications
Improved brain perfusion after electrical cardioversion of atrial fibrillationEuropace
Quantitative 3D imaging parameters improve prediction of hip osteoarthritis outcomeScientific Reports
Childhood overweight and obesity and the risk of depression across the lifespanBMC Pediatrics
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure lociMolecular Psychiatry
Twenty-seven-year time trends in dementia incidence in Europe and the United StatesNeurology
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individualsNature Genetics
Cerebral small vessel disease genomics and its implications across the lifespanNature Communications
Body size at birth and age-related macular degeneration in old ageActa Ophthalmologica
Correction toOsteoporosis International
Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic StenosisJAMA Cardiology
Association of common genetic variants with brain microbleedsNeurology
Greater Bone Marrow Adiposity Predicts Bone Loss in Older WomenJournal of Bone and Mineral Research
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucosePLoS ONE
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conductionNature Communications
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary FibrosisAmerican Journal of Respiratory and Critical Care Medicine
Molecular screening of familial hypercholesterolemia in IcelandersScandinavian Journal of Clinical and Laboratory Investigation
Circulating protein signatures and causal candidates for type 2 diabetesDiabetes
Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetesPLoS Medicine
Traction Bronchiectasis/Bronchiolectasis is Associated with Interstitial Lung Abnormality MortalityEuropean Journal of Radiology
Type 2 diabetes, change in depressive symptoms over time, and cerebral small vessel diseaseDiabetes Care
Antihypertensive medications and risk for incident dementia and Alzheimer's diseaseThe Lancet Neurology
Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestryPharmacogenomics Journal
Repositioning of the global epicentre of non-optimal cholesterolNature
Assessing cardiovascular risks from a mid-thigh CT image: A tree-based machine learning approach using radiodensitometric distributionsScientific Reports
The associations of interstitial lung abnormalities with cancer diagnoses and mortalityThe European respiratory journal
Associations of Omega-3 Fatty acids with Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults.American Journal of Epidemiology
Genetic loci associated with prevalent and incident myocardial infarction and coronary heart disease in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) ConsortiumPLoS ONE
National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratioInternational Journal of Epidemiology
Lifestyle and 25-hydroxy-vitamin D among community-dwelling old adults with dementia, mild cognitive impairment, or normal cognitive functionAging clinical and experimental research

2019

Pre-diagnostic 25-hydroxyvitamin D levels and survival in cancer patientsCancer Causes and Control
Author CorrectionNature Genetics
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processingNature Genetics
Publisher CorrectionNature Genetics
Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetesAmerican Journal of Clinical Nutrition
NýsköpunLæknablaðið
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influencesNature Genetics
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol InteractionsAmerican Journal of Epidemiology
Assessment of the Relationship between Genetic Determinants of Thyroid Function and Atrial FibrillationJAMA Cardiology
Predicting health and life span with the deep plasma proteomeNature Medicine
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotypeNature Genetics
Rising rural body-mass index is the main driver of the global obesity epidemic in adultsNature
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressureHuman Molecular Genetics
Genetic architecture of subcortical brain structures in 38,851 individualsNature Genetics
Imaging patterns are associated with interstitial lung abnormality progression and mortalityAmerican Journal of Respiratory and Critical Care Medicine
Comparability of Plasma Iohexol Clearance Across Population-Based CohortsAmerican Journal of Kidney Diseases
Large-scale parcellation of the ventricular system using convolutional neural networks
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery DissectionJournal of the American College of Cardiology
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levelsNature Genetics
Body fat distribution on computed tomography imaging and prostate cancer risk and mortality in the AGES-Reykjavik studyCancer
Unsupervised brain lesion segmentation from MRI using a convolutional autoencoder
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activityNature Communications
Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and Von Willebrand Factor Plasma LevelsCirculation
Oncostatin M reduces atherosclerosis development in APOE3Leiden.CETP mice and is associated with increased survival probability in humansPLoS ONE
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuriaNature Communications
Hand and knee osteoarthritis are associated with reduced diameters in retinal vesselsRheumatology International
Distribution of cerebral microbleeds in the East and WestNeurology
Disentangling the genetics of lean massAmerican Journal of Clinical Nutrition
Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without DiabetesHepatology Communications
Cardiovascular risk factors and incident giant cell arteritisScandinavian Journal of Rheumatology
Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European CohortsNutrients
Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanismsAlzheimer's and Dementia
Serum magnesium and calcium levels in relation to ischemic strokeNeurology
Type 2 diabetes and obesity in midlife and breast cancer risk in the Reykjavik cohortCancer Causes and Control
Author CorrectionNature Communications
A meta-analysis of genome-wide association studies identifies multiple longevity genesNature Communications
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based settingNeurology
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep durationNature Communications
SegAE: Unsupervised white matter lesion segmentation from brain MRIs using a CNN autoencoderNeuroImage: Clinical
Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik StudyPLoS ONE
A genome-wide association study identifies genetic loci associated with specific lobar brain volumesCommunications Biology
The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)PLoS ONE
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traitsEuropean Journal of Human Genetics
Associations of autozygosity with a broad range of human phenotypesNature Communications
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE ConsortiumAmerican Journal of Hypertension
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipidsNature Genetics
World Health Organization cardiovascular disease risk chartsThe Lancet Global Health
Serum lipids in adults with late age-related macular degeneration: a case-control studyLipids in Health and Disease
Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and MortalityCirculation
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesityNature Genetics
Dynamic sitting: Measurement and associations with metabolic healthJournal of Sports Sciences
Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairmentScientific Reports
Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected IndividualsJournal of the American College of Cardiology
Association between Unrecognized Myocardial Infarction and Cerebral Infarction on Magnetic Resonance ImagingJAMA Neurology
Validation of a metabolite panel for a more accurate estimation of glomerular filtration rate using quantitative LC-MS/MSClinical Chemistry
Omega-3 fatty acids and genome-wide interaction analyses reveal DPP10–pulmonary function associationAmerican Journal of Respiratory and Critical Care Medicine
Prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in older adultsEuropean Heart Journal
A catalog of genetic loci associated with kidney function from analyses of a million individualsNature Genetics
Structural covariability hubs in old ageNeuroImage
Cardiovascular Risk Factors Associated with Venous ThromboembolismJAMA Cardiology
Biofidelic finite element models for accurately classifying hip fracture in a retrospective clinical study of elderly women from the AGES Reykjavik cohortBone

2018

Reliable quantification of marrow fat content and unsaturation level using in vivo MR spectroscopyMagnetic Resonance in Medicine
Heritability and genome-wide associations studies of cerebral blood flow in the general populationJournal of Cerebral Blood Flow and Metabolism
Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older AdultsJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Langtímahorfur sjúklinga með bráða kransæðastífluLæknablaðið
Predictors of carotid plaque progression over a 4-year follow-up in the Reykjavik REFINE-studyAtherosclerosis
CorrectionPLoS ONE
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetesNature Genetics
Associations between Proportion of Plasma Phospholipid Fatty Acids, Depressive Symptoms and Major Depressive Disorder. Cross-Sectional Analyses from the AGES Reykjavik StudyJournal of Nutrition, Health and Aging
Midlife metabolic factors and prostate cancer risk in later lifeInternational Journal of Cancer
Erratum toNature Genetics
Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetesPLoS Medicine
Interstitial lung abnormalities and physical functionERJ Open Research
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT IntervalsCirculation. Genomic and precision medicine
Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum Vitamin D with pulmonary functionBritish Journal of Nutrition
Cigarette smoking and hip volumetric bone mineral density and cortical volume loss in older adultsBone
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traitsNature Genetics
Clinical significance of cerebral microbleeds on MRIInternational Journal of Stroke
Predicting changes in quality of life for patients in vocational rehabilitation
Assessment of the genetic and clinical determinants of fracture riskThe BMJ
Meta-analysis of exome array data identifies six novel genetic loci for lung functionWellcome Open Research
Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populationsPharmacogenomics Journal
Effects of Vitamin D supplementation on markers for cardiovascular disease and type 2 diabetesAmerican Journal of Clinical Nutrition
Dietary intake is associated with risk of multiple myeloma and its precursor diseasePLoS ONE
The AGES-Reykjavik Study suggests that change in kidney measures is associated with subclinical brain pathology in older community-dwelling personsKidney International
The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomyScandinavian Journal of Gastroenterology
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individualsNature Genetics
Population distribution of traditional and the emerging cardiovascular risk factors carotid plaque and IMT: the REFINE-Reykjavik study with comparison with the Tromsø studyBMJ Open
Atrial fibrillation is associated with decreased total cerebral blood flow and brain perfusionEuropace
Multi-ethnic genome-wide association study for atrial fibrillationNature Genetics
Characteristics of recurrent fracturesOsteoporosis International
Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervalsPharmacogenomics Journal
Chronic Kidney Disease Is Associated With Greater Bone Marrow AdiposityJournal of Bone and Mineral Research
Co-regulatory networks of human serum proteins link genetics to diseaseScience
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activityNature Communications
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive functionNature Communications
Exome chip analysis identifies low-frequency and rare variants in MRPL38 for white matter hyperintensities on brain magnetic resonance imagingStroke
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participantsInternational Journal of Epidemiology
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomesNature Communications
Association of Unrecognized Myocardial Infarction with Long-term Outcomes in Community-Dwelling Older AdultsJAMA Cardiology
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM studyHuman Molecular Genetics
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesityNature Genetics
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestriesPLoS ONE
Sex differences in the spatial distribution of bone in relation to incident hip fractureBone
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volumeNature Communications
Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's diseaseAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary functionNature Communications
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studiesEuropean Heart Journal
Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 1; peer reviewWellcome Open Research
Advanced quantitative methods in correlating sarcopenic muscle degeneration with lower extremity function biometrics and comorbiditiesPLoS ONE
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypesNature Genetics
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6Genome Biology
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood PressureAmerican Journal of Human Genetics
Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin CNephrology Dialysis Transplantation
Sex hormones are negatively associated with vertebral bone marrow fatBone
Ný íslensk beinbrotarannsókn Hjartaverndar undirstrikar mikilvßgi verklags Landspítala aα "grípa brotin"Laeknabladid
Dietary habits in adolescence and midlife and risk of breast cancer in older womenPLoS ONE
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR IntervalCirculation. Genomic and precision medicine
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex DisordersAmerican Journal of Human Genetics
Interstitial lung abnormalities and self-reported health and functional statusThorax

2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body massNature Communications
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiationNature Genetics
Úr gögnum HjartaverndarLaeknabladid
Causal effect of plasminogen activator inhibitor type 1 on coronary heart diseaseJournal of the American Heart Association
Differential associations between retinal signs and CMBs by locationNeurology
Oral glucose tolerance test predicts increased carotid plaque burden in patients with acute coronary syndromePLoS ONE
Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial dataPLoS ONE
Rare and low-frequency coding variants alter human adult heightNature
Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortiumPLoS ONE
CorrectionAging
Genetic Improvement of Runtime and its Fitness Landscape in a Bioinformatics Application
Genetic Obesity and the Risk of Atrial FibrillationCirculation
The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypesEuropean Respiratory Journal
Early life residence, fish consumption, and risk of breast cancerCancer Epidemiology Biomarkers and Prevention
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016The Lancet
Associations of fat and muscle tissue with cognitive status in older adultsAge and Ageing
Úr gögnum HjartaverndarLaeknabladid
Novel genetic loci associated with hippocampal volumeNature Communications
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney functionScientific Reports
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and functionThe Journal of clinical investigation
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traitsNature Communications
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen ConsortiumScientific Reports
Trends in the incidence of dementiaEuropean Journal of Epidemiology
Exome-wide association study of plasma lipids in >300,000 individualsNature Genetics
Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkersHeart
Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking InteractionsCirculation
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass indexMolecular Psychiatry
Space and location of cerebral microbleeds, cognitive decline, and dementia in the communityNeurology
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the KidneyHypertension
Imminent risk of fracture after fractureOsteoporosis International
CorrigendumScientific Reports
Genetically determined plasma lipid levels and risk of diabetic retinopathyDiabetes
ErratumPLoS Genetics
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in ErythropoiesisAmerican Journal of Human Genetics
Large perivascular spaces visible on magnetic resonance imaging, cerebral small vessel disease progression, and risk of dementiaJAMA Neurology
The AGES-Reykjavik study atlasesMedical Image Analysis
Long-Term Hormone Replacement Therapy Is Associated with Low Coronary Artery Calcium Levels in a Cohort of Older WomenJournal of the American Geriatrics Society
A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervalsJournal of Medical Genetics
The complex genetics of gait speedAging
Prevalence of heart failure in the elderly and future projectionsScandinavian Cardiovascular Journal
Bone disease in monoclonal gammopathy of undetermined significanceBlood advances
The use of predictive models in dynamic treatment planning
Discovery of novel heart rate-associated loci using the Exome ChipHuman Molecular Genetics
PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and StrokeCirculation: Cardiovascular Genetics
Aortic stiffness and change in glomerular filtration rate and albuminuria in older peopleNephrology Dialysis Transplantation
Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myelomaBlood advances
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and FunctionJournal of the American Society of Nephrology
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.Nature Genetics
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer riskNature Genetics
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesityNature Genetics
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 IndividualsCirculation. Cardiovascular genetics
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular riskNature Genetics
Fibrosis as measured by the biomarker, tissue inhibitor metalloproteinase-1, predicts mortality in Age Gene Environment Susceptibility-Reykjavik (AGES-Reykjavik) StudyEuropean Heart Journal
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillationNature Genetics
Frailty and Risk of Cardiovascular Diseases in Older PersonsRejuvenation Research
Comparison of summer and winter objectively measured physical activity and sedentary behavior in older adults: Age, gene/environment susceptibility Reykjavik studyInternational Journal of Environmental Research and Public Health
Incidence of Brain Infarcts, Cognitive Change, and Risk of Dementia in the General PopulationStroke
Associations of 24-hour sleep duration and CT-derived measurements of muscle and boneExperimental Gerontology
A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1–5 in human plasmaProteomics
Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk PredictionAmerican Journal of Epidemiology
Allometric scaling of brain regions to intra-cranial volumeHuman Brain Mapping
Association of Triglyceride-Related Genetic Variants With Mitral Annular CalcificationJournal of the American College of Cardiology
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitnessNature Communications
Omega-6 fatty acid biomarkers and incident type 2 diabetesThe Lancet Diabetes and Endocrinology
Proximal Femur Volumetric Bone Mineral Density and MortalityJournal of Bone and Mineral Research
Evidence for large-scale gene-by-smoking interaction effects on pulmonary functionInternational Journal of Epidemiology
Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the ElderlyAmerican Journal of Kidney Diseases
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's diseaseNature Genetics
Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary riskPLoS ONE
Hjartabilun meðal eldri ÍslendingaLaeknabladid
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adultsPLoS Genetics

2016

Determinants of outcome of vocational rehabilitationWork
Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analysesNature Genetics
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in DiabetesDiabetes
Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's DiseasePLoS Genetics
Association of Forced Vital Capacity with the Developmental Gene NCOR2PLoS ONE
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participantsLancet
Prevalence and determinants of carotid plaque in the cross-sectional REFINE-Reykjavik studyBMJ Open
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analysesNature Genetics
Meta-analysis of genome-wide association studies of HDL cholesterol response to statinsJournal of Medical Genetics
A century of trends in adult human heighteLife
Novel Genetic Loci Associated with Retinal Microvascular DiameterCirculation: Cardiovascular Genetics
Association between interstitial lung abnormalities and all-cause mortalityJAMA - Journal of the American Medical Association
Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction StudyPLoS Genetics
52 Genetic Loci Influencing Myocardial MassJournal of the American College of Cardiology
Novel genetic loci underlying human intracranial volume identified through genome-wide associationNature Neuroscience
Measurement of Circulating Phospholipid Fatty AcidsJournal of the American College of Nutrition
Cardiac and Carotid Markers Link with Accelerated Brain AtrophyArteriosclerosis, Thrombosis, and Vascular Biology
Comparison of Handgrip and Leg Extension Strength in Predicting Slow Gait Speed in Older AdultsJournal of the American Geriatrics Society
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participantsLancet (London, England)
Muscle Quality and MyosteatosisAmerican Journal of Epidemiology
The association between midlife physical activity and depressive symptoms in late lifeJournals of Gerontology - Series A Biological Sciences and Medical Sciences
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individualsNature Genetics
Post-stroke bacteriuria among stroke patients attending a physiotherapy clinic in Ghana: a cross-sectional studyTherapeutics and Clinical Risk Management
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction StudyPLoS Genetics
Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik studyAtherosclerosis
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortiumAging Cell
Gene-gene Interaction Analyses for Atrial FibrillationScientific Reports
Prevalence and complications of chronic kidney disease in a representative elderly population in IcelandNephrology Dialysis Transplantation
Pineal gland volume assessed by MRI and its correlation with 6-sulfatoxymelatonin levels among older menJournal of Biological Rhythms
Fish and fish-liver oil consumption in adolescence and midlife and risk of CHD in older womenPublic Health Nutrition
Natriuretic peptides and integrated risk assessment for cardiovascular diseaseThe Lancet Diabetes and Endocrinology
A century of trends in adult human heighteLife
Shared genetic contribution to ischemic stroke and Alzheimer's diseaseAnnals of Neurology
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease riskNature Communications
Influence of day length and physical activity on sleep patterns in older Icelandic men and womenJournal of Clinical Sleep Medicine
Genetic influences on schizophrenia and subcortical brain volumesNature Neuroscience
Identification of additional risk loci for stroke and small vessel diseaseThe Lancet Neurology
Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2Journal of Bone and Mineral Research
Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adultsBehavioural Brain Research
Genome-Wide Association Study for Incident Myocardial Infarction and Coronary Heart Disease in Prospective Cohort StudiesPLoS ONE
Multiethnic Exome-Wide Association Study of Subclinical AtherosclerosisCirculation: Cardiovascular Genetics
Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's DiseaseJournal of Alzheimer's Disease
Are bone turnover markers associated with volumetric bone density, size, and strength in older men and women? The AGES–Reykjavik studyOsteoporosis International
Seasonal changes in vitamin D-effective UVB availability in Europe and associations with population serum 25-hydroxyvitamin DNutrients
Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and MemoryHypertension
Mortality in Older Persons with Retinopathy and Concomitant Health Conditions the Age, Gene/Environment Susceptibility-Reykjavik StudyOphthalmology
Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individualsAlzheimer's and Dementia
Interactive graph-cut segmentation for fast creation of finite element models from clinical ct data for hip fracture predictionComputer Methods in Biomechanics and Biomedical Engineering
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney functionNature Communications
Prevalence and prognosis of non-ischemic patterns of late gadolinium enhancement in older adults by cardiovascular MR in the Iceland-MI studyJournal of Cardiovascular Magnetic Resonance
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 IndividualsAmerican Journal of Human Genetics
Midlife cardiovascular risk factors and late-life unrecognized and recognized myocardial infarction detect by cardiac magnetic resonanceJournal of the American Heart Association
Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated DiseasesAmerican Journal of Human Genetics
Trends in adult body-mass index in 200 countries from 1975 to 2014The Lancet
Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell TraitsAmerican Journal of Human Genetics
Association of lipid-related genetic variants with the incidence of atrial fibrillationPLoS ONE
High-sensitivity cardiac troponin i is a strong predictor of cardiovascular events and mortality in the ages-reykjavik community-based cohort of older individualsClinical Chemistry
A novel Alzheimer disease locus located near the gene encoding tau proteinMolecular Psychiatry
Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association StudiesPLoS Genetics
Occupation as a risk factor for renal cell cancerScandinavian Journal of Urology
Hearing in older adults with exfoliation syndrome/exfoliation glaucoma or primary open-angle glaucomaActa Ophthalmologica
Physical activity and incidence of sarcopeniaAge and Ageing
Targeted sequencing of genome wide significant loci associated with bone mineral density (BMD) reveals significant novel and rare variantsHuman Molecular Genetics
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leannessNature Medicine
Incidence and prevalence of total joint replacements due to osteoarthritis in the elderlyBMC Musculoskeletal Disorders
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E InteractionsGenetic Epidemiology
Vitamin D deficiency in EuropeAmerican Journal of Clinical Nutrition
Late-life brain volumeNeurobiology of Aging
GWAS for executive function and processing speed suggests involvement of the CADM2 geneMolecular Psychiatry
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait lociNature Genetics
Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traitsNature Genetics
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preferenceProceedings of the National Academy of Sciences of the United States of America
Association of bone turnover markers with volumetric bone loss, periosteal apposition, and fracture risk in older men and womenOsteoporosis International
Genome-wide association study identifies 74 loci associated with educational attainmentNature
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levelsJournal of Medical Genetics
Left–right differences in the proximal femur’s strength of post-menopausal womenOsteoporosis International
Associations between arterial stiffness, depressive symptoms and cerebral small vessel diseaseJournal of Psychiatry and Neuroscience

2015

Segmental kidney volumes measured by dynamic contrast-enhanced magnetic resonance imaging and their association with CKD in older peopleAmerican Journal of Kidney Diseases
Whole-genome sequencing identifies EN1 as a determinant of bone density and fractureNature
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysisThe Lancet Diabetes and Endocrinology
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repairNature Genetics
Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik StudyJournal of Nutritional Science
Directional dominance on stature and cognition in diverse human populationsNature
Brain Volume as an Integrated Marker for the Risk of Death in a Community-Based SampleJournals of Gerontology - Series A Biological Sciences and Medical Sciences
A Meta-analysis of Gene Expression Signatures of Blood Pressure and HypertensionPLoS Genetics
Lifetime risk of stage 3–5 CKD in a community-based sample in IcelandClinical Journal of the American Society of Nephrology
Aortic Stiffness and Kidney Disease in an Elderly PopulationAmerican Journal of Nephrology
Carotid atherosclerosis and cardiovascular health metrics in old subjects from the AGES-Reykjavik studyAtherosclerosis
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery diseaseNature Genetics
Common genetic variants influence human subcortical brain structuresNature
Integrative pathway genomics of lung function and airflow obstructionHuman Molecular Genetics
Genome-wide studies of verbal declarative memory in nondemented older peopleBiological Psychiatry
Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adultsObesity Reviews
Genetic studies of body mass index yield new insights for obesity biologyNature
New genetic loci link adipose and insulin biology to body fat distributionNature
Multiethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRICirculation: Cardiovascular Genetics
Fine mapping the CETP region reveals a common intronic insertion associated to HDL-Cnpj Aging and Mechanisms of Disease
Muscle quality and muscle fat infiltration in relation to incident mobility disability and gait speed declineJournals of Gerontology - Series A Biological Sciences and Medical Sciences
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction StudyPLoS Genetics
Carotid arterial stiffness and risk of incident cerebral microbleeds in older peopleArteriosclerosis, Thrombosis, and Vascular Biology
Novel loci associated with usual sleep durationMolecular Psychiatry
Salivary cortisol, brain volumes, and cognition in community-dwelling elderly without dementiaNeurology
PLD3 variants in population studiesNature
Sex-specific predictors of hearing-aid use in older personsInternational Journal of Audiology
Cerebral small vessel disease and association with higher incidence of depressive symptoms in a general elderly populationAmerican Journal of Psychiatry
The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjectsMolecular Psychiatry
Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular diseasePLoS ONE
White Matter Lesion ProgressionStroke
Plasma phospholipid PUFAs are associated with greater muscle and knee extension strength but not with changes in muscle parameters in older adultsJournal of Nutrition
A blunted diurnal cortisol response in the lower educated does not explain educational differences in coronary heart diseaseSocial Science and Medicine
Fat distribution and mortalityObesity
Plasma phospholipid fatty acids and fish-oil consumption in relation to osteoporotic fracture risk in older adultsAmerican Journal of Clinical Nutrition
Mediation analysis of aortic stiffness and renal microvascular functionJournal of the American Society of Nephrology
Covariate-adjusted measures of discrimination for survival dataBiometrical Journal
Cod liver oil consumption at different periods of life and bone mineral density in old ageBritish Journal of Nutrition
Midlife Blood Pressure and Late-Life GFR and AlbuminuriaAmerican Journal of Kidney Diseases
Comparing GFR estimating equations using cystatin C and creatinine in elderly individualsJournal of the American Society of Nephrology
Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA RepairObstetrical and Gynecological Survey
Genome-wide association study of kidney function decline in individuals of European descentKidney International
Risk factors associated with incident cerebral microbleeds according to location in older peopleJAMA Neurology
Convergent genetic and expression data implicate immunity in Alzheimer's diseaseAlzheimer's and Dementia
Genetic contributions to variation in general cognitive functionMolecular Psychiatry
Molecular mechanisms underlying variations in lung functionThe Lancet Respiratory Medicine
Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive proteinPLoS ONE
Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density lociPLoS ONE
Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly menEuropean Urology
Circadian clock genes and risk of fatal prostate cancerCancer Causes and Control
Physical activity from early adulthood and risk of prostate cancerCancer Prevention Research
Overweight and obesity in midlife and brain structure and dementia 26 years laterAmerican Journal of Epidemiology
GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacyJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Relations between aortic stiffness and left ventricular structure and function in older participants in the age, gene/environment susceptibility-reykjavik studyCirculation: Cardiovascular Imaging
Feasibility of Using Pseudo-Continuous Arterial Spin Labeling Perfusion in a Geriatric Population at 1.5 TeslaPLoS ONE
Polyunsaturated fatty acids in relation to incident mobility disability and decline in gait speed; The Age, Gene/Environment Susceptibility-Reykjavik StudyEuropean Journal of Clinical Nutrition
Age-related macular degeneration and mortality in community-dwelling eldersOphthalmology
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibilityNature Communications
Modulation of genetic associations with serum urate levels by body-mass-index in humansPLoS ONE
Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer DiseaseCirculation
Higher Plasma Phospholipid n-3 PUFAs, but Lower n-6 PUFAs, Are Associated with Lower Pulse Wave Velocity among Older Adults^1-3Journal of Nutrition
Cardiac hemodynamics are linked with structural and functional features of brain agingJournal of the American Heart Association
N-terminal pro-brain natriuretic peptide and abnormal brain agingNeurology

2014

Structural MRI correlates of apathy symptoms in older persons without dementiaNeurology
Community awareness of stroke in Accra, GhanaBMC Public Health
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associationsAmerican Journal of Human Genetics
Gene-wide analysis detects two new susceptibility genes for Alzheimer's diseasePLoS ONE
Spousal loss and cognitive function in later lifeAmerican Journal of Epidemiology
Midlife migraine and late-life parkinsonismNeurology
Fracture risk assessment in older adults using a combination of selected quantitative computed tomography bone measuresJournal of Clinical Densitometry
Five-year incidence, progression, and risk factors for age-related macular degenerationOphthalmology
Rannsóknarstöd hjartaverndar, fortíd og nútídLaeknabladid
Diabetes, markers of brain pathology and cognitive functionAnnals of Neurology
Pulse pressure relation to aortic and left ventricular structure in the age, gene/environment susceptibility (AGES)-reykjavik studyHypertension
Joint effect of mid- and late-life blood pressure on the brainNeurology
Inflammatory cytokines and risk of coronary heart diseaseEuropean Heart Journal
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarizationNature Genetics
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statinsNature Communications
Different susceptibility of medial temporal lobe and basal ganglia atrophy rates to vascular risk factorsNeurobiology of Aging
Adipose tissue density, a novel biomarker predicting mortality risk in older adultsJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Faster increase in body mass index between ages 8 and 13 is associated with risk factors for cardiovascular morbidity and mortalityNutrition, Metabolism and Cardiovascular Diseases
Association of low-density lipoprotein cholesterol - Related genetic variants with aortic valve calcium and incident aortic stenosisJAMA - Journal of the American Medical Association
The alcohol paradoxJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Hip fractures and bone mineral density in the elderly - Importance of serum 25-hydroxyvitamin DPLoS ONE
The challenges of genome-wide interaction studiesPLoS ONE
Genome-wide association analysis identifies six new loci associated with forced vital capacityNature Genetics
Novel genetic markers associate with atrial fibrillation risk in Europeans and JapaneseJournal of the American College of Cardiology
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacksAmerican Journal of Human Genetics
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterolAmerican Journal of Human Genetics
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male pubertyHuman Molecular Genetics
Milk consumption throughout life and bone mineral content and density in elderly men and womenOsteoporosis International
Impairments in hearing and vision impact on mortality in older peopleAge and Ageing
Assessing risk prediction models using individual participant data from multiple studiesAmerican Journal of Epidemiology
Longitudinal and circumferential strain of the proximal aortaJournal of the American Heart Association
Adipose tissue, muscle, and functionDiabetes Care
Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass indexPLoS Genetics
Epidemiology of fractures in Iceland and secular trends in major osteoporotic fractures 1989-2008Osteoporosis International
Assessment of incident spine and hip fractures in women and men using finite element analysis of CT scansJournal of Bone and Mineral Research
Multi-ethnic fine-mapping of 14 central adiposity lociHuman Molecular Genetics
Glycated hemoglobin measurement and prediction of cardiovascular diseaseJAMA - Journal of the American Medical Association
Midlife determinants associated with sedentary behavior in old ageMedicine and Science in Sports and Exercise
Longitudinal changes in size and composition of carotid artery plaques using ultrasoundJournal for Vascular Ultrasound
The prevalence of aortic stenosis in the elderly in Iceland and predictions for the coming decadesInternational Journal of Cardiology
Circulating sclerostin associated with vertebral bone marrow fat in older men but not womenJournal of Clinical Endocrinology and Metabolism
Gene-age interactions in blood pressure regulationAmerican Journal of Human Genetics
The incidence of a first major osteoporotic fracture in Iceland and implications for FRAXOsteoporosis International
ErratumOsteoporosis International
Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levelsCirculation. Cardiovascular genetics
Genetic determinants of heel bone propertiesHuman Molecular Genetics
Defining the role of common variation in the genomic and biological architecture of adult human heightNature Genetics
Is there a sex difference in accelerometer counts during walking in older adults?Journal of Physical Activity and Health
Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in childrenAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Drug-gene interactions and the search for missing heritabilityPharmacogenomics Journal
Serum carboxymethyllysine, an advanced glycation end product, and age-related macular degenerationJAMA Ophthalmology
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillationCirculation
Profile and health-related quality of life of Ghanaian stroke survivorsClinical Interventions in Aging
B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation riskEuropace
Genetic diversity is a predictor of mortality in humansBMC Genetics
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarcheNature
Population assessment of future trajectories in coronary heart disease mortalityPLoS ONE
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung functionPLoS ONE

2013

Type 3 finger length pattern is associated with total knee replacements due to osteoarthritis but not with hip replacements or hand osteoarthritis in the elderlyBMC Musculoskeletal Disorders
The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetesPLoS ONE
Midlife physical activity preserves lower extremity function in older adultsJournal of the American Geriatrics Society
Persistence of the effect of birth size on dysglycaemia and type 2 diabetes in old ageAge
ATP5H/KCTD2 locus is associated with Alzheimer's disease riskMolecular Psychiatry
Pulmonary function impairment may be an early risk factor for late-life cognitive impairmentJournal of the American Geriatrics Society
A genome-wide association study of early menopause and the combined impact of identified variantsHuman Molecular Genetics
ErratumNature Genetics
Objective measurements of daily physical activity patterns and sedentary behaviour in older adultsAge and Ageing
Early peak height velocity and cardiovascular disease mortality among Icelandic womenAnnals of Medicine
A genome-wide association study of depressive symptomsBiological Psychiatry
Structural patterns of the proximal femur in relation to age and hip fracture risk in womenBone
ErratumEuropean Heart Journal
Candidate gene association study of bmi-related loci, weight, and adiposity in old ageJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Genetic associations with valvular calcification and aortic stenosisNew England Journal of Medicine
Insights into the Genetic Architecture of Early Stage Age-Related Macular DegenerationPLoS ONE
Similarities and differences between sexes in regional loss of cortical and trabecular bone in the mid-femoral neckJournal of Bone and Mineral Research
Stefnumörkun í heilbrigdismálumLaeknabladid
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's diseaseCell
Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium ConcentrationsPLoS Genetics
Proximal femoral density distribution and structure in relation to age and hip fracture risk in womenJournal of Bone and Mineral Research
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's diseaseNature Genetics
Copy Number Variations in Alternative Splicing Gene Networks Impact LifespanPLoS ONE
Lack of association between the MTHFR C677T variant and migraine with aura in an older populationCephalalgia
Large-scale association analysis identifies new risk loci for coronary artery diseaseNature Genetics
Are C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore?PLoS ONE
Serum vitamin D and parathyroid hormone in relation to cardiac structure and functionJournal of Clinical Endocrinology and Metabolism
Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adultsJournal of Clinical Endocrinology and Metabolism
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disordersNature Genetics
Association of heat shock proteins with all-cause mortalityAge
Effect of finite element model loading condition on fracture risk assessment in men and womenBone
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational AttainmentScience
Causal Relationship between Obesity and Vitamin D StatusPLoS Medicine
Socioeconomic factors from midlife predict mobility limitation and depressed mood three decades later; findings from the AGES-Reykjavik Study.BMC Public Health
Coronary artery calcium and physical performance as determinants of mortality in older ageInternational Journal of Cardiology
Consumption of Fish Products across the Lifespan and Prostate Cancer RiskPLoS ONE
Association of adiposity genetic variants with menarche timing in 92,105 women of European descentAmerican Journal of Epidemiology
Prevalence of airflow obstruction in nonsmoking older individuals using different spirometric criteriaCOPD: Journal of Chronic Obstructive Pulmonary Disease
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architectureNature Genetics
Genome-wide association study meta-analysis of chronic widespread painAnnals of the Rheumatic Diseases
Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarctsStroke
CRP is associated with lung function decline in men but not womenRespiratory Medicine
Genome-Wide Association Study of Retinopathy in Individuals without DiabetesPLoS ONE
The Molecular Genetic Architecture of Self-EmploymentPLoS ONE
Effects of exercise training and nutrition counseling on body composition and cardiometabolic factors in old individualsEuropean Geriatric Medicine
Best Practices and Joint Calling of the HumanExome BeadChipPLoS ONE
Sleep disruption among older men and risk of prostate cancerCancer Epidemiology Biomarkers and Prevention
N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular eventsEuropean Heart Journal
ErratumEuropean Heart Journal
Changes in total cholesterol levels in Western societies are not related to statin, but rather dietary factorsEuropean Heart Journal
Common variants associated with plasma triglycerides and risk for coronary artery diseaseNature Genetics
Genetic variation associated with circulating monocyte count in the eMERGE NetworkHuman Molecular Genetics
Discovery and refinement of loci associated with lipid levelsNature Genetics
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with auraCephalalgia
Association of type D personality with unhealthy lifestyle, and estimated risk of coronary events in the general Icelandic population.European Journal of Preventive Cardiology
Associations of current and remitted major depressive disorder with brain atrophyPsychological Medicine
Genetic Loci for Retinal Arteriolar MicrocirculationPLoS ONE
ErratumNature Genetics
Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsNature Genetics
Simple risk model predicts incidence of atrial fibrillation in a racially and geographically diverse populationJournal of the American Heart Association
Hemostatic Factors and Risk of Coronary Heart Disease in General PopulationsPLoS ONE
ErratumNature Genetics
Common variants in mendelian kidney disease genes and their association with renal functionJournal of the American Society of Nephrology
Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studiesBMC Public Health
Áhrif 6 mánaða fjölþættrarþjálfunar á hreyfigetu, vöðvakraft, þol og líkamsþyngdarstuðul eldri einstaklinga. Eru áhrif þjálfunar sambærileg hjá konum og körlum?Læknabladid
Migraine, depression, and brain volumeNeurology

2012

Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney FunctionPLoS Genetics
Evaluation of the postural stability of elderly persons using time domain signal analysisJournal of Vestibular Research: Equilibrium and Orientation
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary FunctionPLoS Genetics
FTO genotype is associated with phenotypic variability of body mass indexNature
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstructionAmerican Journal of Respiratory and Critical Care Medicine
Milk intake in early life and risk of advanced prostate cancerAmerican Journal of Epidemiology
Identification of common variants associated with human hippocampal and intracranial volumesNature Genetics
Common variants at 12q14 and 12q24 are associated with hippocampal volumeNature Genetics
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in womenPLoS Genetics
Coronary artery calcium distributions in older persons in the AGES-reykjavik studyEuropean Journal of Epidemiology
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAMMolecular Psychiatry
Effect of Birth Year on Birth Weight and Obesity in AdulthoodPLoS ONE
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populationsNature Genetics
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fractureNature Genetics
Brain tissue volumes in the general population of the elderly. The AGES-Reykjavik Study.NeuroImage
Effects of a 6-month multimodal training intervention on retention of functional fitness in older adultsInternational Journal of Behavioral Nutrition and Physical Activity
C-reactive protein, fibrinogen, and cardiovascular disease predictionNew England Journal of Medicine
The use of digital photographs for the diagnosis of hand osteoarthritisBMC Musculoskeletal Disorders
Common genetic variation in the 3β-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk the aortagen consortiumCirculation: Cardiovascular Genetics
Interleukin-6 receptor pathways in coronary heart diseaseThe Lancet
Tengsl búsetu fyrstu 20 æviárin við áhættu á sykursýki af tegund 2Laeknabladid
Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik studyAge and Ageing
Adult height and the risk of cause-specific death and vascular morbidity in 1 million peopleInternational Journal of Epidemiology
Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortiumHuman Genetics
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney functionHuman Molecular Genetics
Mid-thigh cortical bone structural parameters, muscle mass and strength, and association with lower limb fractures in older men and women (AGES-Reykjavik Study)Calcified Tissue International
Genome-wide meta-analysis of common variant differences between men and womenHuman Molecular Genetics
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathwaysNature Genetics
Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik StudyNeurobiology of Aging
Cerebral microbleeds and age-related macular degenerationNeurobiology of Aging
Langvinnir sjúkdómarLaeknabladid
Common variants at 6q22 and 17q21 are associated with intracranial volumeNature Genetics
Genetic, physiological, and lifestyle predictors of mortality in the general populationAmerican Journal of Public Health
Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adultsJAMA - Journal of the American Medical Association
Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation MeasurementsPLoS ONE
Lipid-related markers and cardiovascular disease predictionJAMA - Journal of the American Medical Association
ErratumNature Genetics
Lifelong physical activity in maintaining bone strength in older men and women of the Age, Gene/environment susceptibility-reykjavik studyOsteoporosis International
The promises and pitfalls of genoeconomicsAnnual Review of Economics
Serum levels of marine-derived n-3 fatty acids in Icelanders, Japanese, Koreans, and Americans-A descriptive epidemiologic studyProstaglandins Leukotrienes and Essential Fatty Acids
Age-related loss of proximal femoral strength in elderly men and womenBone
Retinopathy in old persons with and without diabetes mellitusDiabetologia
Rye bread consumption in early life and reduced risk of advanced prostate cancerCancer Causes and Control
Meta-analysis identifies six new susceptibility loci for atrial fibrillationNature Genetics
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistanceNature Genetics
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathwaysNature Genetics

2011

Genome-wide association study for coronary artery calcification with follow-up in myocardial infarctionCirculation
Validity of retrospective diet historyJournal of Nutrition, Health and Aging
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profileNature Genetics
A genome-wide association study of agingNeurobiology of Aging
Association between C reactive protein and coronary heart diseaseBMJ
Genome-wide association studies of cerebral white matter lesion burdenAnnals of Neurology
Improving the prediction of incident atrial fibrillationArchives of Internal Medicine
Trends in the incidence and prevalence of atrial fibrillation in Iceland and future projectionsEuropace
The presence of total knee or hip replacements due to osteoarthritis enhances the positive association between hand osteoarthritis and atherosclerosis in womenAnnals of the Rheumatic Diseases
RANTES/CCL5 and risk for coronary eventsPLoS ONE
Effects of statin medication on mortality risk associated with type 2 diabetes in older persons: the population-based AGES-Reykjavik StudyBMJ Open
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaqueNature Genetics
Arterial stiffness, pressure and flow pulsatility and brain structure and functionBrain
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traitsPLoS Genetics
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung functionNature Genetics
Prevalence of age-related macular degeneration in old personsOphthalmology
Childhood growth and adult hypertension in a population of high birth weightHypertension
A genome-wide association study of agingNeurobiology of Aging
Distribution of cortical bone in the femoral neck and hip fractureBone
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressureNature Genetics
Personalized Epigenomic Signatures That Are Stable over Time and Covary with Body Mass Index (Science Translational Medicine (2011) 3, (65er1))Science Translational Medicine
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetesInvestigative Ophthalmology and Visual Science
Physical activity attenuates the influence of FTO variants on obesity riskPLoS Medicine
N-terminal pro-brain natriuretic peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in older men with and without pre-existing cardiovascular diseaseJournal of the American College of Cardiology
Diabetes mellitus, fasting glucose, and risk of cause-specific deathNew England Journal of Medicine
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery diseaseCirculation: Cardiovascular Genetics
CUBN is a gene locus for albuminuriaJournal of the American Society of Nephrology
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery diseaseNature Genetics
Associations of visceral and liver fat with the metabolic syndrome across the spectrum of obesityObesity
Association of hypertension drug target genes with blood pressure and hypertension in 86 588 individualsHypertension
Meta-analysis of genome-wide association for migraine in six population-based European cohortsEuropean Journal of Human Genetics
Multiple loci are associated with white blood cell phenotypesPLoS Genetics
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levelsCirculation
Male-female differences in the association between incident hip fracture and proximal femoral strengthBone
Genetic variants in novel pathways influence blood pressure and cardiovascular disease riskNature
Hand osteoarthritis severity is associated with total knee joint replacements independently of BMI. The Ages-Reykjavik studyOpen Rheumatology Journal
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1American Journal of Human Genetics
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesDiabetes
ErratumNature Genetics

2010

Chronic kidney disease and risk of major cardiovascular disease and non-vascular mortalityBMJ (Online)
The effect of midlife physical activity on cognitive function among older adultsJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and womenNeurobiology of Aging
Common variants in KCNN3 are associated with lone atrial fibrillationNature Genetics
NT-proBNP is associated with coronary heart disease risk in healthy older women but fails to enhance prediction beyond established risk factorsAtherosclerosis
Myocardial structure and function by echocardiography in relation to glucometabolic status in elderly subjects from 2 population-based cohortsAmerican Heart Journal
New loci associated with kidney function and chronic kidney diseaseNature Genetics
IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetesGrowth Hormone and IGF Research
Genome-wide association analysis identifies multiple loci related to resting heart rateHuman Molecular Genetics
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studiesNature Genetics
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factorsCirculation: Cardiovascular Genetics
Markers of dysglycaemia and risk of coronary heart disease in people without diabetesPLoS Medicine
Coronary artery calcium, brain function and structureStroke
Genome-wide association studies of mri-defined brain infarctsStroke
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortalityThe Lancet
Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphismsCirculation
Analysing the large decline in coronary heart disease mortality in the icelandic population aged 25-74 between the years 1981 and 2006PLoS ONE
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distributionNature Genetics
Four novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In vivoPLoS Genetics
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular diseaseThe Lancet
Personalized epigenomic signatures that are stable over time and covary with body mass indexScience Translational Medicine
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levelsHuman Molecular Genetics
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conductionNature Genetics
Validation of an atrial fibrillation risk algorithm in Whites and African AmericansArchives of Internal Medicine
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six loci influencing serum magnesium levelsPLoS Genetics
A Meta-analysis of four genome-wide association studies of survival to age 90 years or olderJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Uromodulin levels associate with a common UMOD variant and risk for incident CKDJournal of the American Society of Nephrology
Correlation of echocardiographic findings with cerebral infarction in elderly adultsStroke
Genome-wide analysis of genetic loci associated with Alzheimer diseaseJAMA - Journal of the American Medical Association
Hundreds of variants clustered in genomic loci and biological pathways affect human heightNature
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexNature Genetics
Persistent Chlamydia Pneumoniae serology is related to decline in lung function in women but not in men. Effect of persistent Chlamydia pneumoniae infection on lung functionBMC Pulmonary Medicine
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studiesLancet
Cerebral microbleeds, retinopathy, and dementiaNeurology
Genome-wide association study of PR intervalNature Genetics
Effect of rheumatoid factor on mortality and coronary heart diseaseAnnals of the Rheumatic Diseases
Migraine with aura and risk of cardiovascular and all cause mortality in men and womenBMJ (Online)

2009

Multiple loci associated with indices of renal function and chronic kidney diseaseNature Genetics
B-type natriuretic peptides and cardiovascular riskCirculation
Migraine headache in middle age and late-life brain infarctsObstetrical and Gynecological Survey
C-reactive protein in migraine sufferers similar to that of non-migraineursCephalalgia
Glycemic status and brain injury in older individualsDiabetes Care
Cardiovascular genetics in IcelandEuropean Heart Journal
Cerebral infarcts and cognitive performance importance of location and number of infarctsStroke
Unfavourable risk factors for type 2 diabetes mellitus are already apparent more than a decade before onset in a population-based study of older personsEuropean Journal of Epidemiology
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortalityJAMA
Meta-analysis of genome-wide association data identifies two loci influencing age at menarcheNature Genetics
Hand osteoarthritis in older women is associated with carotid and coronary atherosclerosisAnnals of the Rheumatic Diseases
The interaction of adiposity with the CRP gene affects CRP levelsInternational Journal of Obesity
Multiple loci influence erythrocyte phenotypes in the CHARGE ConsortiumNature Genetics
Major lipids, apolipoproteins, and risk of vascular diseaseJAMA
NRXN3Is a novel locus for waist circumferencePLoS Genetics
Genome-wide association study of blood pressure and hypertensionNature Genetics
Abnormal T-wave axis is associated with coronary artery calcification in older adultsScandinavian Cardiovascular Journal
Lipoprotein(a)Current Opinion in Cardiology
Þróun holdafars og sykursýki í 40 ár á íslandiLaeknabladid
Microvascular lesions in the brain and retinaAnnals of Neurology
Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestryNature Genetics
High hand joint mobility is associated with radiological CMC1 osteoarthritisOsteoarthritis and Cartilage
Genome-wide association meta-analysis for total serum bilirubin levelsHuman Molecular Genetics
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium design of prospective meta-analyses of genome-wide association studies from 5 CohortsCirculation: Cardiovascular Genetics
Ventricular dilationAnnals of Neurology
Migraine headache in middle age and late-life brain infarctsJAMA - Journal of the American Medical Association

2008

White matter lesions and cognitive performanceJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Einkenni og teikn fótameins hjá íslenskum sjúklingum meǒ sykursýki af tegund 2Laeknabladid
The association of telomere length with paternal history of premature myocardial infarction in the European Atherosclerosis Research Study IIJournal of Molecular Medicine
Cognitive impairmentAmerican Journal of Epidemiology
Cerebral microbleeds in the population based AGES-Reykjavik studyJournal of Neurology, Neurosurgery and Psychiatry
Localized measures of callosal atrophy are associated with late-life hypertensionNeuroImage
Intra-individual change over time in DNA methylation with familial clusteringJAMA - Journal of the American Medical Association
Early discharge and home intervention reduces unit costs after total hip replacementInternational Journal of Health Care Finance and Economics
Birth weight and risk of type 2 diabetes a systematic reviewJAMA - Journal of the American Medical Association
Hemodynamics of increased pulse pressure in older women in the community-based age, gene/environment susceptibility-Reykjavik studyHypertension
Retinal and cerebral microvascular signs and diabetes the age, gene/environment susceptibility-reykjavik studyDiabetes
Lipoprotein(a) levels and risk of future coronary heart diseaseArchives of Internal Medicine
Long-term interleukin-6 levels and subsequent risk of coronary heart diseasePLoS Medicine
Genoeconomics

2007

Increasing glucose levels and BMI predict future heart failure. Experience from the Reykjavík StudyEuropean Journal of Heart Failure
Renal function and risk of coronary heart disease in general populationsPLoS Medicine
Triglycerides and the risk of coronary heart diseaseCirculation
Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registryEuropean Journal of Epidemiology
Monoclonal gammopathyHaematologica
Nordic biological specimen banks as basis for studies of cancer causes and control - More than 2 million sample donors, 25 million person years and 100 000 prospective cancersActa Oncologica
Optimum expression of adult lung function based on all-cause mortalityRespiratory Medicine
Estimation of 10-year risk of fatal cardiovascular disease and coronary heart disease in Iceland with results comparable with those of the Systematic Coronary Risk Evaluation projectEuropean Journal of Preventive Cardiology
Age, gene/environment susceptibility-reykjavik studyAmerican Journal of Epidemiology
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseasesEuropean Journal of Epidemiology
A variant in CDKAL1 influences insulin response and risk of type 2 diabetesNature Genetics
Protein expression within the human renal cortex and renal cell carcinomaCell Preservation Technology
Forspárgildi QRS útslaga á hjartalínuriti, Minnesota-líkanid, un dánartídni karla. Reykjavíkurrannsókn Hjartaverndar.Læknabladid
Algengi sykursýki af tegund tvö á Islandi 1967-2002.Læknabladid
Population-based register of acute myocardial infarctionEuropean Journal of Cardiovascular Prevention and Rehabilitation
Circulating concentrations of insulin markers and coronary heart diseaseEuropean Heart Journal
Infant feeding patterns and midlife erythrocyte sedimentation rateActa Paediatrica, International Journal of Paediatrics

2006

Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanismsAtherosclerosis
Increasing sex difference in bone strength in old ageBone
Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on MI in the Icelandic populationAtherosclerosis
Genetic Screening in Populations
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetesNature Genetics
A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarctionNature Genetics
Skaðleg áhrif reykinga á heilsufar hafa verið verulega vanmetin. Niðurstöður úr hóprannsóknum HjartaverndarLæknabladid

2005

Glucose abnormalities and heart failure predict poor prognosis in the population-based Reykjavík StudyEuropean Journal of Cardiovascular Prevention and Rehabilitation
Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adultsNephrology Dialysis Transplantation
ErratumNature Genetics
The association between glucose abnormalities and heart failure in the population-based Reykjavík StudyDiabetes Care
Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced riskJournal of Experimental Medicine
Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatmentCirculation
Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controlsPLoS Medicine
Mótefnatengd sykursýki af tegund 2 á IslandiLæknabladid
Reducing costs after total hip replacement
Short hospital stay augmented with education and home-based rehabilitation improves function and quality of life after hip replacementActa Orthopaedica

2004

C-reactive protein and coronary heart disease [1] (multiple letters)New England Journal of Medicine
C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart DiseaseNew England Journal of Medicine
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight populationEuropean Journal of Clinical Nutrition
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and strokeNature Genetics
The absolute risk of recurrent myocardial infarction is similar amongst both sexesEuropean Journal of Preventive Cardiology
Familial risk of lung carcinoma in the Icelandic populationJournal of the American Medical Association
Loss of teeth and coronary heart diseaseInternational Journal of Prosthodontics

2003

Erythrocyte Sedimentation Rate, an Independent Predictor of Coronary Heart Disease in Men and WomenAmerican Journal of Epidemiology
Breytingar á reykingavenjum miðaldra og eldri Íslendinga síðastliðin þrjátíu ár og ástæður þeirra : niðurstöður úr hóprannsóknum HjartaverndarLæknablaðið
Subclinical intestinal inflammationGastroenterology
Family history of myocardial infarction increases the risk of coronary heart disease, independent of other risk factorsEvidence-based Cardiovascular Medicine
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2American Journal of Human Genetics
The gene encoding phosphodiesterase 4D confers risk of ischemic strokeNature Genetics
Áhættuþættir hjarta- og æðasjúkdóma meðal fimmtugra á Akureyri og í Hafnarfirði : staða og áhrif einfaldrar íhlutunarLæknablaðið
Systematic family screening for familial hypercholesterolemia in IcelandArteriosclerosis, Thrombosis, and Vascular Biology
Notkun náttúruefna, fæðubótarefna og lausasölulyfja : hönnun og prófun spurningalistaLæknablaðið

2002

Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik StudyEuropean Journal of Cardiovascular Prevention & Rehabilitation
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight populationAmerican Journal of Clinical Nutrition
Localization of a susceptibility gene for common forms of stroke to 5q12American Journal of Human Genetics
Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31American Journal of Human Genetics
Size at birth and coronary artery disease in a population with high birth weightAmerican Journal of Clinical Nutrition
Relationship between size at birth and hypertension in a genetically homogenous population of high birth weightJournal of Hypertension
Declining coronary heart disease mortality in IcelandScandinavian Cardiovascular Journal
Fifteen percent of myocardial infarctions and coronary revascularizations explained by family history unrelated to conventional risk factorsEuropean Heart Journal

2001

The effect of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate reductase gene on homocysteine levels in elderly men and women from the British regional heart studyAtherosclerosis
Hómócystein, fólat og kóbalamín í íslenskum konum og körlumLæknablaðið
The -629C > A polymorphism in the CETP gene does not explain the association of TaqIB polymorphism with risk and age of myocardial infarction in Icelandic menAtherosclerosis
Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged menThrombosis and Haemostasis
Arfbundin kólesterólhækkun : yfirlit yfir stöðu þekkingar og árangur markvissrar leitar á ÍslandiLæknablaðið
Þróun ofþyngdar og offitu meðal 45-64 ára Reykvíkinga á árunum 1975-1994Læknablaðið
Breytingar á tíðni kransæðasjúkdóma á ÍslandiLæknablaðið

2000

Treatment with different doses of folic acid in haemodialysis patientsNephrology Dialysis Transplantation
Variants in the cholesterol ester transfer protein and lipoprotein lipase genes are predictors of plasma cholesterol response to dietary changeAtherosclerosis

1999

Erythrocyte sedimentation rate (esr) as a predictor of cardiovascular death. the reykjavik studyScandinavian Cardiovascular Journal, Supplement
The asp9 to asm polymorphism in lipoprotein lipase affects plasma triglyceride levels but not the risk of developing ml in the homogenous icelandic populationScandinavian Cardiovascular Journal, Supplement
A common polymorphism in the cholesteryl ester transfer protein gene affects plasma hdl concentration and the risk of myocardial infarction in the homogenous icelandic populationScandinavian Cardiovascular Journal, Supplement
The genetic determinants of hyper-lipidaemia
Hyperhomocysteinaemia, genetics and cardiovascular disease riskEuropean Heart Journal
The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemiaAtherosclerosis
Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populationsEuropean Journal of Clinical Investigation

1998

Detection of the low density lipoprotein receptor gene PvuII intron 15 polymorphism using the polymerase chain reactionDisease Markers
Linkage disequilibrium at the cystathionine β synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteineAnnals of Human Genetics
C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR)Atherosclerosis

1997

Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemiaClinical Chemistry
Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and lipoprotein traits in a population sample from IcelandGenetic Epidemiology
Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non-smoking healthy men, and the effect on plasma HDL cholesterol and apoAI concentrationClinical Genetics
Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. The IFCC Scientific DivisionJournal of the International Federation of Clinical Chemistry / IFCC
Spectrum of LDL receptor gene mutations in heterozygous familial hypercholesterolemiaHuman Mutation
The usefulness of three biallelic restriction fragment length polymorphisms versus a polymorphic dinucleotide tandem repeat polymorphism at the low-density-lipoprotein receptor gene locus for diagnosis of familial hypercholesterolemiaDisease Markers
Common founder mutation in the LDL receptor gene causing familial hypercholesterolaemia in the Icelandic populationHuman Mutation

1996

High throughput modifications of single-strand conformation polymorphism analysis : mutation detection in familial hypercholesterolemia
Use of the single strand conformation polymorphism method for rapid screening for mutations in the low density lipoprotein receptor gene in patients with familial hypercholesterolemiaZeitschrift für Gastroenterologie

1995

Utilities for high throughput use of the single strand conformational polymorphism methodJournal of Medical Genetics
Effect of the StuI polymorphism in the LDL receptor gene (Ala 370 to Thr) on lipid levels in healthy individualsClinical Genetics
Response to drugs and diet in a compound heterozygote for familial hypercholesterolaemiaArchives of Disease in Childhood
Dried template DNA, dried PCR oligonucleotides and mailing in 96-well platesBioTechniques
SSCP analysis and DNA sequencing for genetic characterization of a multi-allelic disorder, familial hypercholesterolaemia

1994

Effect on plasma lipid levels of different classes of mutations in the low-density lipoprotein receptor gene in patients with familial hypercholesterolemiaArteriosclerosis, Thrombosis, and Vascular Biology
Handling of large (300 x 400 mm), thin (0.4 mm) polyacrylamide gels and recovery as dried gelsBioTechniques

1993

Identification of recurrent and novel mutations in exon 4 of the LDL receptor gene in patients with familial hypercholesterolemia in the United KingdomArteriosclerosis and Thrombosis
Use of the single-strand conformational polymorphism method to detect recurrent and novel mutations in the low-density lipoprotein repeptor gene in patients with familial hypercholesterolaemiaThe Clinical Investigator
Six DNA polymorphisms in the low density lipoprotein receptor geneJournal of Medical Genetics
The molecular genetics of pediatric lipid disordersPediatric Research
ASSOCIATION OF APOLIPOPROTEIN-E POLYMORPHISM WITH PLASMA-LEVELS OF HIGH-DENSITY-LIPOPROTEIN AND LIPOPROTEIN(A), AND EFFECT OF DIET IN HEALTHY-MEN AND WOMENNutrition Metabolism and Cardiovascular Diseases
Identification of common genetic polymorphisms that determine plasma levels of ApoAI and HDL-CAtherosclerosis

1992

Þéttni fituprótína í ÍslendingumLæknablaðið
Interaction between a polymorphism of the apo A-I promoter region and smoking determines plasma levels of HDL and apo A-IArteriosclerosis and Thrombosis
Characterization of deletions in the LDL receptor gene in patients with familial hypercholesterolemia in the United KingdomArteriosclerosis and Thrombosis

1991

Identification of the 664 proline to leucine mutation in the low density lipoprotein receptor in four unrelated patients with familial hypercholesterolaemia in the UKClinical Genetics
PCR-based method to create a specific mutation as a reference for oligomeltingClinical Chemistry

1990

Kólesteról í blóði : áhrif erfðaþáttaLæknablaðið

1989

Polymorphism of the c‐Ha‐ras‐1 proto‐oncogene in sporadic and familial breast cancerInternational Journal of Cancer
A study of familial hypercholesterolemia in Iceland using RFLPsJournal of Medical Genetics

1987

Specific polypeptide differences in normal versus malignant human breast tissues by two-dimensional electrophoresisBreast Cancer Research and Treatment

1986

Catabolite repressive effects of 5-thio-D-glucose on Saccharomyces cerevisiae.Journal of General Microbiology

1985

Suppression of temperature sensitive mutations in oncogene-related CDC genes in Saccharomyces cerevisiae by catabolite repression resistance and cytoplasmic petite mutationsCurrent Genetics

1984

Isoenzyme pattern and subcellular localization of hexokinases in human breast cancer and nonpathological breast tissueInternational Journal of Cancer

Keywords for Specialisation:

Genetic epidemiology