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Snævar Sigurðsson - Research Specialist
–
Heilbrigðisvísindasvið
Snævar Sigurðsson
Íslenska
Research Specialist
Location
Læknagarður / Lg-456
Email
snaevar [at] hi.is
Unit
BioMedical Center
ORCID site
https://orcid.org/0000-0003-4860-6311
Research portal – Snævar Sigurðsson
Published works
2023
Aroylated phenylenediamine HO53 modulates innate immunity, histone acetylation and metabolism.
Molecular immunology
Evaluating Prophylactic Effect of Bovine Colostrum on Intestinal Barrier Function in Zonulin Transgenic Mice: A Transcriptomic Study
International Journal of Molecular Sciences
2022
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells.
Journal of innate immunity
Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model.
Laboratory animal research
2021
Metabolic and Transcriptional Changes across Osteogenic Differentiation of Mesenchymal Stromal Cells
Bioengineering
2020
Azithromycin has lung barrier protective effects in a cell model mimicking ventilator-induced lung injury.
ALTEX
Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells.
Frontiers in cell and developmental biology
Azithromycin ameliorates sulfur dioxide-induced airway epithelial damage and inflammatory responses.
Respiratory research
2019
Common and rare sequence variants influencing tumor biomarkers in blood.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia.
Respiratory research
2018
A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease.
Nature communications
2017
Sequence variant at 4q25 near PITX2 associates with appendicitis.
Scientific reports
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability.
Nature genetics
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations.
NPJ genomic medicine
Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
Nature communications
2014
Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24.
Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder.
Rare mutations associating with serum creatinine and chronic kidney disease.
2013
Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing.
Genome-wide profiling of target genes for the systemic lupus erythematosus-associated transcription factors IRF5 and STAT4.
Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.
2012
Copy number expansion of the STX17 duplication in melanoma tissue from Grey horses.
2011
A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.
Mutation discovery in mice by whole exome sequencing.
Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping.
Performance of microarray and liquid based capture methods for target enrichment for massively parallel sequencing and SNP discovery.
2010
Fine-mapping and mutation analysis of TRPM1: a candidate gene for leopard complex (LP) spotting and congenital stationary night blindness in horses.
Identification of the bovine Arachnomelia mutation by massively parallel sequencing implicates sulfite oxidase (SUOX) in bone development.
A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus.
Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.
2009
Genome sequence, comparative analysis, and population genetics of the domestic horse.
Science (New York, N.Y.)
2008
Variants of the interferon regulatory factor 5 gene regulate expression of IRF5 mRNA in atherosclerotic tissue but are not associated with myocardial infarction.
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.
Journal of medical genetics
2007
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis.
An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
2006
A microarray system for genotyping 150 single nucleotide polymorphisms in the coding region of human mitochondrial DNA.
Genomics
2005
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
2003
Quantitative evaluation by minisequencing and microarrays reveals accurate multiplexed SNP genotyping of whole genome amplified DNA.
2002
Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.
Multiplex SNP genotyping in pooled DNA samples by a four-colour microarray system.
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