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Sædís Sævarsdóttir - Professor

Sædís Sævarsdóttir

–

School of Health Sciences

Sædís Sævarsdóttir

Professor

Professor and Vice Head of the Faculty of Medicine, consultant in rheumatology at Landspitali University Hospital, project leader at deCODE genetics

Location
Sturlugata 8
Phone
5701900
Email
saedis [at] hi.is

Unit
Faculty of Medicine

Published works

2024

Genome-Wide Association Study of Accessory Atrioventricular PathwaysJAMA Cardiology
Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk DeterminantsArthritis and Rheumatology
Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid diseaseNature Communications
Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritisRheumatology (United Kingdom)
Variants at the Interleukin 1 Gene Locus and PericarditisJAMA Cardiology
The correlation between CpG methylation and gene expression is driven by sequence variantsNature Genetics
Correction toNature
Sequence variants influencing the regulation of serum IgG subclass levelsNature Communications

2023

Evaluation of an individually tailored smoking-cessation intervention for patients with rheumatoid arthritis in an outpatient clinicScandinavian Journal of Rheumatology
Disease-modifying antirheumatic drugs and risk of thyroxine-treated autoimmune thyroid disease in patients with rheumatoid arthritisJournal of Internal Medicine
Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapyRMD Open
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effectAnnals of the Rheumatic Diseases
Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticariaCommunications Biology
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethalityNature Communications
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammationAnnals of the Rheumatic Diseases
Large-scale plasma proteomics comparisons through genetics and disease associationsNature
Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritisRMD Open
Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethalityNature Communications

2022

Comorbidities and treatment patterns in early rheumatoid arthritisRMD Open
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint ReplacementsArthritis & rheumatology (Hoboken, N.J.)
Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritisArthritis Research and Therapy
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?Arthritis Research and Therapy
Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestationsJoint Bone Spine
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B CellsFrontiers in Immunology
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2Communications Biology
A genome-wide meta-analysis identifies 53 sequence variants associating with carpal tunnel syndrome
Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid ArthritisClinical Pharmacology and Therapeutics
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subsetAnnals of the Rheumatic Diseases
Sleep problems in rheumatoid arthritis over 12 years from diagnosisRMD Open
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndromeNature Communications
The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritisRheumatology (Oxford, England)
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subsetAnnals of the rheumatic diseases.

2021

Rheumatoid arthritis autoantibodies and their association with age and sexClinical and Experimental Rheumatology
Genetic variants associated with platelet count are predictive of human disease and physiological markersCommunications Biology
Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications Biology
Social stressors and risk of rheumatoid arthritis and their relationship to known modifiable risk factorsScandinavian Journal of Rheumatology
Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritisArthritis Research and Therapy
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in IcelandArthritis and Rheumatology
Comorbidities at diagnosis of rheumatoid arthritisRheumatology (Oxford, England)
Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control studyArthritis Research and Therapy
Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid ArthritisArthritis Care and Research
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacementsArthritis and Rheumatology
A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid ArthritisFrontiers in Immunology
A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigoCommunications Biology
Mortality over 14 years in MTX-refractory patients randomized to a strategy of addition of infliximab or sulfasalazine and hydroxychloroquineRheumatology (United Kingdom)
Large-scale integration of the plasma proteome with genetics and diseaseNature Genetics

2020

Occupational physical workload and development of anti-collagen type II antibodies in rheumatoid arthritisClinical and Experimental Rheumatology
Drug Tolerant Anti-drug Antibody Assay for Infliximab Treatment in Clinical Practice Identifies Positive Cases EarlierFrontiers in Immunology
The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritisJournal of Internal Medicine
Abatacept in rheumatoid arthritisArthritis Research and Therapy
Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activityArthritis Research & Therapy
Does autoimmune thyroid disease affects rheumatoid arthritis disease activity or response to methotrexate?RMD Open
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid diseaseNature
Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritisSeminars in Arthritis and Rheumatism
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian womenNature Communications
An updated matrix to predict rapid radiographic progression of early rheumatoid arthritis patientsRheumatology (United Kingdom)
Anti–Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid ArthritisArthritis & Rheumatology

2019

Serum biomarkers for prediction of response to methotrexate monotherapy in early rheumatoid arthritisJournal of Rheumatology
Smoking and response to rituximab in rheumatoid arthritisScandinavian Journal of Rheumatology
Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritisRMD Open
Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritisScandinavian Journal of Rheumatology
Predicting risk for radiographic damage in rheumatoid arthritisCurrent Medical Research and Opinion
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39Annals of the Rheumatic Diseases
Periodontal health and oral microbiota in patients with rheumatoid arthritisJournal of Clinical Medicine

2018

Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritisSeminars in Arthritis and Rheumatism
Anti–Carbamylated Protein Antibodies and Higher Baseline Disease Activity in Rheumatoid Arthritis—A Replication Study in Three CohortsArthritis and Rheumatology
Risk of Thyroxine-Treated Autoimmune Thyroid Disease Associated With Disease Onset in Patients With Rheumatoid ArthritisJAMA network open

2017

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosusAnnals of the Rheumatic Diseases
Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritisAnnals of the Rheumatic Diseases
Obesity is a strong predictor of worse clinical outcomes and treatment responses in early rheumatoid arthritisRMD Open
A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate FailureArthritis and Rheumatology
Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-upAnnals of the Rheumatic Diseases

2016

Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritisRMD Open
Remaining Pain in Early Rheumatoid Arthritis Patients Treated With MethotrexateArthritis Care and Research
Family history of rheumatoid arthritisNature Reviews Rheumatology
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritisNature Communications
A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort studyArthritis Research and Therapy
Développement d'une matrice de risque de la progression radiographique rapide à 1 an après diagnostic d'une polyarthrite rhumatoïde débutanteRevue du Rhumatisme (Edition Francaise)
Correlates of leisure time physical inactivity in a scandinavian populationJournal of Physical Activity and Health
Does a family history of RA influence the clinical presentation and treatment response in RA?Annals of the Rheumatic Diseases
Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritisAnnals of the Rheumatic Diseases

2015

Brief reportArthritis and Rheumatology
Recent infections are associated with decreased risk of rheumatoid arthritisAnnals of the Rheumatic Diseases
Parity influences the severity of ACPA-negative early rheumatoid arthritisArthritis Research and Therapy
Infektioner kopplades till minskad risk för reumatoid artritLakartidningen
Postmenopausal hormone therapy and the risk of rheumatoid arthritisEuropean Journal of Epidemiology
Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activityArthritis Research and Therapy
Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexateArthritis Research and Therapy
Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritisAnnals of the Rheumatic Diseases
Pretreatment multi-biomarker disease activity score and radiographic progression in early RAAnnals of the Rheumatic Diseases
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritisAnnals of the Rheumatic Diseases

2014

Association between life events and rheumatoid arthritisArthritis Care and Research
Accelerating translational research by clinically driven development of an informatics platform-A case studyPLoS ONE
Thyroxin substitution and the risk of developing rheumatoid arthritis; Results from the Swedish population-based EIRA studyAnnals of the Rheumatic Diseases
Response toAnnals of the Rheumatic Diseases
Patients with regular physical activity before onset of rheumatoid arthritis present with milder diseaseAnnals of the Rheumatic Diseases
Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritisAnnals of the Rheumatic Diseases

2013

Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritisBMC Musculoskeletal Disorders
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid ArthritisPLoS Genetics
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritisAnnals of the Rheumatic Diseases

2012

Influence of FCGR3A genotype on the therapeutic response to rituximab in rheumatoid arthritisBMJ Open
Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritisPharmacogenetics and Genomics
Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritisArthritis and Rheumatism
In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully preventedAnnals of the Rheumatic Diseases

2011

Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitorsArthritis and Rheumatism
Predicting response to treatment in patients with rheumatoid arthritisEuropean Musculoskeletal Review
Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokersArthritis Research and Therapy
Predictors of response to methotrexate in early DMARD naïve rheumatoid arthritisAnnals of the Rheumatic Diseases

2010

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapyArthritis and Rheumatism

2008

Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in icelandic multicase systemic lupus erythematosus familiesArthritis and Rheumatism
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infectionClinical Infectious Diseases

2007

Mannan-binding lectin may facilitate the clearance of circulating immune complexes - Implications from a study on C2-deficient individualsClinical and Experimental Immunology
Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controlsJournal of Rheumatology

2006

kafli 13: Gigtsjúkdómar og klínísk ónæmisfræði
Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosusAnnals of the Rheumatic Diseases

2005

Postgraduate medical education in Iceland; medical students’ and residents’ attitudeLæknablaðið
Afstada unglaekna og laeknanema til sérfraedináms á Islandi.Læknabladid
Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced riskJournal of Experimental Medicine

2004

Human Plasma-Derived Mannose-Binding LectinScandinavian Journal of Immunology
The potential role of mannan-binding lectin in the clearance of self-components including immune complexesScandinavian Journal of Immunology

2001

Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective studyJournal of Rheumatology

Keywords for Specialisation:

Genetic epidemiology

Precision medicine

Personalised medicine