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Sædís Sævarsdóttir - Professor
–
School of Health Sciences
Sædís Sævarsdóttir
Íslenska
Professor
Professor and Vice Head of the Faculty of Medicine, consultant in rheumatology at Landspitali University Hospital, project leader at deCODE genetics
Location
Sturlugata 8
Phone
5701900
Email
saedis [at] hi.is
Unit
Faculty of Medicine
ORCID site
https://orcid.org/0000-0001-9392-6184
Research portal – Sædís Sævarsdóttir
Courses 2024 - 2025
LÆK202F - Internal Medicine, theoretical
LÆK203F - Internal Medicine, Clinical
LÆK623F - Personalised medicine from a Nordic perspective
Published works
2024
Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk Determinants
Arthritis and Rheumatology
Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease
Nature Communications
Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
Nature Genetics
Variants at the Interleukin 1 Gene Locus and Pericarditis
JAMA Cardiology
Genome-Wide Association Study of Accessory Atrioventricular Pathways
JAMA Cardiology
The correlation between CpG methylation and gene expression is driven by sequence variants
Nature Genetics
Correction to
Nature
Sequence variants influencing the regulation of serum IgG subclass levels
Nature Communications
Genome-wide investigation of persistence with methotrexate treatment in early rheumatoid arthritis
Rheumatology (United Kingdom)
2023
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effect
Annals of the Rheumatic Diseases
Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritis
RMD Open
Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria
Communications Biology
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
Nature Communications
Disease-modifying antirheumatic drugs and risk of thyroxine-treated autoimmune thyroid disease in patients with rheumatoid arthritis
Journal of Internal Medicine
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation
Annals of the Rheumatic Diseases
Large-scale plasma proteomics comparisons through genetics and disease associations
Nature
Evaluation of an individually tailored smoking-cessation intervention for patients with rheumatoid arthritis in an outpatient clinic
Scandinavian Journal of Rheumatology
Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
Nature Communications
Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapy
RMD Open
2022
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells
Frontiers in Immunology
A genome-wide meta-analysis identifies 53 sequence variants associating with carpal tunnel syndrome
Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid Arthritis
Clinical Pharmacology and Therapeutics
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome
Nature Communications
The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritis
Rheumatology (Oxford, England)
Comorbidities and treatment patterns in early rheumatoid arthritis
RMD Open
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements
Arthritis & rheumatology (Hoboken, N.J.)
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2
Communications Biology
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Annals of the rheumatic diseases.
Sleep problems in rheumatoid arthritis over 12 years from diagnosis
RMD Open
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Annals of the Rheumatic Diseases
Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations
Joint Bone Spine
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?
Arthritis Research and Therapy
Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis
Arthritis Research and Therapy
2021
Social stressors and risk of rheumatoid arthritis and their relationship to known modifiable risk factors
Scandinavian Journal of Rheumatology
Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritis
Arthritis Research and Therapy
Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study
Arthritis Research and Therapy
Rheumatoid arthritis autoantibodies and their association with age and sex
Clinical and Experimental Rheumatology
A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis
Frontiers in Immunology
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland
Arthritis and Rheumatology
Comorbidities at diagnosis of rheumatoid arthritis
Rheumatology (Oxford, England)
A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo
Communications Biology
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements
Arthritis and Rheumatology
Large-scale integration of the plasma proteome with genetics and disease
Nature Genetics
Genetic variants associated with platelet count are predictive of human disease and physiological markers
Communications Biology
Pain Over Two Years After Start of Biologic Versus Conventional Combination Treatment in Early Rheumatoid Arthritis
Arthritis Care and Research
Mortality over 14 years in MTX-refractory patients randomized to a strategy of addition of infliximab or sulfasalazine and hydroxychloroquine
Rheumatology (United Kingdom)
Genetic variants associated with platelet count are predictive of human disease and physiological markers.
Communications Biology
2020
Anti–Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid Arthritis
Arthritis & Rheumatology
Drug Tolerant Anti-drug Antibody Assay for Infliximab Treatment in Clinical Practice Identifies Positive Cases Earlier
Frontiers in Immunology
The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis
Journal of Internal Medicine
Abatacept in rheumatoid arthritis
Arthritis Research and Therapy
Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis
Seminars in Arthritis and Rheumatism
Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity
Arthritis Research & Therapy
Does autoimmune thyroid disease affects rheumatoid arthritis disease activity or response to methotrexate?
RMD Open
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease
Nature
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
Nature Communications
An updated matrix to predict rapid radiographic progression of early rheumatoid arthritis patients
Rheumatology (United Kingdom)
Occupational physical workload and development of anti-collagen type II antibodies in rheumatoid arthritis
Clinical and Experimental Rheumatology
2019
Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis
RMD Open
Smoking and response to rituximab in rheumatoid arthritis
Scandinavian Journal of Rheumatology
Periodontal health and oral microbiota in patients with rheumatoid arthritis
Journal of Clinical Medicine
Serum biomarkers for prediction of response to methotrexate monotherapy in early rheumatoid arthritis
Journal of Rheumatology
Predicting risk for radiographic damage in rheumatoid arthritis
Current Medical Research and Opinion
Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritis
Scandinavian Journal of Rheumatology
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39
Annals of the Rheumatic Diseases
2018
Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis
Seminars in Arthritis and Rheumatism
Risk of Thyroxine-Treated Autoimmune Thyroid Disease Associated With Disease Onset in Patients With Rheumatoid Arthritis
JAMA network open
Anti–Carbamylated Protein Antibodies and Higher Baseline Disease Activity in Rheumatoid Arthritis—A Replication Study in Three Cohorts
Arthritis and Rheumatology
2017
A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate Failure
Arthritis and Rheumatology
Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis
Annals of the Rheumatic Diseases
A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus
Annals of the Rheumatic Diseases
Obesity is a strong predictor of worse clinical outcomes and treatment responses in early rheumatoid arthritis
RMD Open
Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up
Annals of the Rheumatic Diseases
2016
A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study
Arthritis Research and Therapy
Correlates of leisure time physical inactivity in a scandinavian population
Journal of Physical Activity and Health
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
Nature Communications
Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis
Annals of the Rheumatic Diseases
Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate
Arthritis Care and Research
Does a family history of RA influence the clinical presentation and treatment response in RA?
Annals of the Rheumatic Diseases
Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis
RMD Open
Family history of rheumatoid arthritis
Nature Reviews Rheumatology
Développement d'une matrice de risque de la progression radiographique rapide à 1 an après diagnostic d'une polyarthrite rhumatoïde débutante
Revue du Rhumatisme (Edition Francaise)
2015
Postmenopausal hormone therapy and the risk of rheumatoid arthritis
European Journal of Epidemiology
Infektioner kopplades till minskad risk för reumatoid artrit
Lakartidningen
Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity
Arthritis Research and Therapy
Brief report
Arthritis and Rheumatology
Parity influences the severity of ACPA-negative early rheumatoid arthritis
Arthritis Research and Therapy
Pretreatment multi-biomarker disease activity score and radiographic progression in early RA
Annals of the Rheumatic Diseases
Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate
Arthritis Research and Therapy
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis
Annals of the Rheumatic Diseases
Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis
Annals of the Rheumatic Diseases
Recent infections are associated with decreased risk of rheumatoid arthritis
Annals of the Rheumatic Diseases
2014
Accelerating translational research by clinically driven development of an informatics platform-A case study
PLoS ONE
Response to
Annals of the Rheumatic Diseases
Thyroxin substitution and the risk of developing rheumatoid arthritis; Results from the Swedish population-based EIRA study
Annals of the Rheumatic Diseases
Association between life events and rheumatoid arthritis
Arthritis Care and Research
Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis
Annals of the Rheumatic Diseases
Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease
Annals of the Rheumatic Diseases
2013
Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritis
BMC Musculoskeletal Disorders
Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis
PLoS Genetics
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis
Annals of the Rheumatic Diseases
2012
Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis
Arthritis and Rheumatism
In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented
Annals of the Rheumatic Diseases
Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis
Pharmacogenetics and Genomics
Influence of FCGR3A genotype on the therapeutic response to rituximab in rheumatoid arthritis
BMJ Open
2011
Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors
Arthritis and Rheumatism
Predictors of response to methotrexate in early DMARD naïve rheumatoid arthritis
Annals of the Rheumatic Diseases
Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers
Arthritis Research and Therapy
Predicting response to treatment in patients with rheumatoid arthritis
European Musculoskeletal Review
2010
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy
Arthritis and Rheumatism
2008
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection
Clinical Infectious Diseases
Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in icelandic multicase systemic lupus erythematosus families
Arthritis and Rheumatism
2007
Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls
Journal of Rheumatology
Mannan-binding lectin may facilitate the clearance of circulating immune complexes - Implications from a study on C2-deficient individuals
Clinical and Experimental Immunology
2006
kafli 13: Gigtsjúkdómar og klínísk ónæmisfræði
Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus
Annals of the Rheumatic Diseases
2005
Postgraduate medical education in Iceland; medical students’ and residents’ attitude
Læknablaðið
Afstada unglaekna og laeknanema til sérfraedináms á Islandi.
Læknabladid
Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk
Journal of Experimental Medicine
2004
Human Plasma-Derived Mannose-Binding Lectin
Scandinavian Journal of Immunology
The potential role of mannan-binding lectin in the clearance of self-components including immune complexes
Scandinavian Journal of Immunology
2001
Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective study
Journal of Rheumatology
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