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Ragnhildur Þóra Káradóttir - Professor

Ragnhildur Þóra Káradóttir

–

School of Health Sciences

Ragnhildur Þóra Káradóttir

Professor

Location
Læknagarður
Email
ragnhildkara [at] hi.is

Unit
Department of Physiology

Published works

2024

Functional implication for myelin regeneration in recovery from ischaemic strokeBrain
Clemastine and metformin extend the window of NMDA receptor surface expression in ageing oligodendrocyte precursor cellsScientific Reports

2023

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8Cell Reports Medicine
Corrigendum: Electrochemically induced
in vitro focal hypoxia in human neurons.Frontiers in Cell and Developmental Biology
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transferNature

2022

Electrochemically induced in vitro focal hypoxia in human neuronsFrontiers in Cell and Developmental Biology
Signal requirement for cortical potential of transplantable human neuroepithelial stem cellsNature Communications

2021

MyelinScience
Combining whole-cell patch clamp and dye loading in acute brain slices with bulk RNA sequencing in embryonic to aged miceSTAR Protocols
Periods of synchronized myelin changes shape brain function and plasticityNature Neuroscience
The bright and the dark side of myelin plasticitySeminars in Cell and Developmental Biology
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminenceCell Reports
Activity-dependent alteration of early myelin ensheathment in a developing sensory circuitJournal of Comparative Neurology
A Matter of StateNeuroscientist

2020

Problems and Pitfalls of Identifying Remyelination in Multiple SclerosisCell Stem Cell
Unraveling Myelin PlasticityFrontiers in Cellular Neuroscience

2019

Whole-cell patch clamp recordings from oligodendrocyte lineage cells in brain slices
Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with AgeNeuron
Neuronal activity-dependent myelin repair after strokeNeuroscience Letters

2018

White matter plasticity keeps the brain in tuneFrontiers in Cellular Neuroscience
Neuronal activity-dependent control of postnatal neurogenesis and gliogenesisAnnual Review of Neuroscience
Neuroglial interactions underpinning myelin plasticityDevelopmental Neurobiology

2017

Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo ReportersStem Cell Reports
Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged MiceStem Cell Reports
Surpassing light-induced cell damage in vitro with novel cell culture mediaScientific Reports
A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelinationNature Neuroscience
Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode lengthGLIA
De novo myelination of cerebellar granule cell axons triggered by PI(3,4,5)P3-dependent neuronal signals.Nature Neuroscience

2016

Oligodendrocytes in health and diseaseNeuropharmacology
Brain tissue stiffness is a sensitive marker for acidosisJournal of Neuroscience Methods
Glutamate signallingNeuropharmacology
Writing a constructive peer reviewEuropean Journal of Neuroscience

2015

Your ticket to independenceEuropean Journal of Neuroscience
Neuronal activity regulates remyelination via glutamate signaling to oligodendrocyte progenitors.Nature Communications
Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutationsBrain
You are not aloneEuropean Journal of Neuroscience
Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitorsNature Communications

2014

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expressionNature Communications
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disordersEMBO Journal
Aberrant methylation of tRNAs links cellular stress to neurodevelopmental disordersEMBO Journal
Unraveling the secrets of white matter - Bridging the gap between cellular, animal and human imaging studiesNeuroscience
The CNS White MatterNeuroscience

2013

Niche derived oligodendrocyte progenitorsFrontiers in Cellular Neuroscience
Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by OligodendrocytesPLoS Biology
Clever gliaStem Cell Research and Therapy
High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biologyStem Cell Reports
Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potencyJournal of Neuroscience

2012

Deconstructing myelinationNature Methods

2011

Derivation of neural precursor cells from human ES cells at 3% O 2 is efficient, enhances survival and presents no barrier to regional specification and functional differentiationCell Death and Differentiation
Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellumJournal of Physiology
Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.Nature Protocols

2010

Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopyJournal of Biomechanics

2009

Glutamatergic signalling in the brain’s white matter.Neuroscience
The effect of Nacetyl- aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.Brain
Glutamatergic signaling in the brain's white matterNeuroscience
Electrical signalling properties of oligodendrocyte precursor cellsNeuron Glia Biology

2008

CorrigendumNature Neuroscience
Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matterGLIA
Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to oligodendrocytes.GLIA
Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matterNature Neuroscience

2007

Neurotransmitter receptors in the life and death of oligodendrocytesNeuroscience

2006

Aberrant dendritic branching and sensory inputs in the superficial dorsal horn of mice lacking CaMKIIalpha autophosphorylation.Molecular and Cellular Neurosciences
Combining patch-clamping of cells in brain slices with immunocytochemical labelling to define cell type and developmental stage.Nature Protocols
Combining patch-clamping of cells in brain slices with immunocytochemical labeling to define cell type and developmental stageNature Protocols
Aberrant dendritic branching and sensory inputs in the superficial dorsal horn of mice lacking CaMKIIα autophosphorylationMolecular and Cellular Neuroscience

2005

NMDA receptors are expressed in oligodendrocytes and activated in ischaemiaNature
A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cellsJournal of Neuroscience

2004

Reversal or reduction of glutamate and GABA transport in CNS pathology and therapyPflugers Archiv European Journal of Physiology

2002

Differences in prevalence of seasonal affective disorder that are not explained by either genetic or latitude differences.International Journal of Circumpolar Health

2001

Melatonin secretion in SAD patients and healthy subjects matched with respect to age and sex.International Journal of Circumpolar Health

Keywords for Specialisation:

Electrophysiology

Molecular and cellular neuroscience

Cellular physiology