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Rafn Benediktsson - Professor
–
School of Health Sciences
Rafn Benediktsson
Íslenska
Professor
Head of Endocrinology
Location
LSH - Fossvogi
Phone
543 1000
Email
rafn [at] hi.is
Unit
Faculty of Medicine
Website
http://www.uni.hi.is/rafn
ORCID site
https://orcid.org/0000-0002-2954-9801
Research portal – Rafn Benediktsson
Under construction throughout the autumn semester 2023
 
Courses 2023 - 2024
LÆK202F - Internal Medicine, theoretical
LÆK203F - Internal Medicine, Clinical
Education
1995
,
Ph.D.
,
University of Edinburgh
,
Medicine
1987
,
Kandídatspróf
,
University of Iceland
,
Medicine
Published works
2022
Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles - A Mendelian randomization analysis.
European journal of preventive cardiology
2021
Distinction between the effects of parental and fetal genomes on fetal growth.
Nature genetics
[Obesity of a Nation - what can we do?]
Laeknabladid
Loss-of-Function Variants in the Tumor-Suppressor Gene
PTPN14
Confer Increased Cancer Risk.
Cancer research
Caffeine exposure from beverages and its association with self-reported sleep duration and quality in a large sample of Icelandic adolescents.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
2020
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.
Nature
2019
A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy.
Nature communications
Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures (Nature Communications, (2019), 10, 1, (2054), 10.1038/s41467-019-09860-0)
Nature Communications
Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes.
Journal of the American College of Cardiology
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.
Nature communications
The Number of Adults with Incident Type 1 Diabetes Phenotype in Iceland is Half the Number in Children - a Population Based Study.
Diabetes research and clinical practice
2018
Sequence variants associating with urinary biomarkers
Human molecular genetics
Opioid induced pituitary dysfunction,Sjúkratilfelli Truflun á starfsemi heiladinguls vegna ópíóíða
Laeknabladid
[Opioid Induced Pituitary Dysfunction].
Laeknabladid
2017
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
NPJ genomic medicine
Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability.
Nature genetics
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Diabetes
2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Nature genetics
HbA1c 7% verður 53 mmól/mól ný eining frá 1. mars 2015
HbA1c 7% verour 53 mmól/mól -ný eining frá 1. mars 2015
Laeknabladid
The epidemiology of pituitary adenomas in Iceland, 1955-2012: a nationwide population-based study.
European journal of endocrinology
The epidemiology of pituitary adenomas in Iceland, 1955-2012: A nationwide population-based study
European Journal of Endocrinology
2014
Adipose tissue, muscle, and function: potential mediators of associations between body weight and mortality in older adults with type 2 diabetes.
Diabetes care
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Nature genetics
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.
Nature genetics
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.
Nature genetics
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
PLoS genetics
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.
Cell
Frá embætti landlæknis. Vanstarfsemi í skjaldkirtli
Laeknabladid
2013
Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studies.
BMC public health
Genome-wide association study identifies three novel loci for type 2 diabetes.
Human molecular genetics
The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry.
Nutrition, metabolism, and cardiovascular diseases : NMCD
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
Diabetes
2012
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
Diabetes
[Early life residency associated with the risk of developing type 2 diabetes - the population-based Reykjavík study].
Laeknabladid
[Diagnosis and management of hypertension].,Greining, medferd og eftirlit háprýstings.
Læknabladid
Greining, meofero og eftirlit há\+rýstings
Laeknabladid
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
PLoS genetics
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Nature genetics
Circadian gene variants and susceptibility to type 2 diabetes: a pilot study.
PloS one
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
PLoS genetics
[Diagnosis and management of hypertension].
Laeknabladid
A genome-wide association search for type 2 diabetes genes in African Americans.
PloS one
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
Nature genetics
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
PLoS genetics
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
Human molecular genetics
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
PLoS genetics
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
Diabetes
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Nature genetics
Early life residency associated with the risk of developing type 2 diabetes - The population-based Reykjavík Study,Tengsl búsetu fyrstu 20 æviárin vid áhættu á sykursýki af tegund 2
Laeknabladid
2011
Treatment of type 1 diabetes in adults - Problem solved?,Meohöndlun sykursýki af tegund 1 hjá fulloronum - er búio ao leysa málio?
Laeknabladid
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
Nature genetics
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.
Diabetes
[Treatment of type 1 diabetes in adults - problem solved?].
Laeknabladid
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
American Journal of Human Genetics
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.
PLoS genetics
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Diabetes
Erratum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Nature Genetics
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.
Nature genetics
The Lin28/let-7 axis regulates glucose metabolism.
Cell
Retinopathy in old persons with and without diabetes mellitus: the Age, Gene/Environment Susceptibility--Reykjavik Study (AGES-R).
Diabetologia
Effects of statin medication on mortality risk associated with type 2 diabetes in older persons: the population-based AGES-Reykjavik Study.
BMJ open
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Nature genetics
2010
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))
Nature Genetics
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Nature genetics
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Nature genetics
2009
[Self-care and empowerment in diabetes care: use of instruments in clinical practice - a review].
Laeknabladid
Parental origin of sequence variants associated with complex diseases.
Nature
Unfavourable risk factors for type 2 diabetes mellitus are already apparent more than a decade before onset in a population-based study of older persons: from the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik).
European journal of epidemiology
Self-care and empowerment in diabetes care: Use of instruments in clinical practice - a review,Sjálfsumönnun og sjálfsefling fólks meö sykursýki Tillaga aö nálgun meö leiöbeinandi matskvöröum - yfirlitsgrein
Laeknabladid
Instruments to tailor care of people with type 2 diabetes.
Journal of advanced nursing
2008
Foot disease in Icelandic patients with established type 2 diabetes,Einkenni og teikn fótameins hjá iś lenskum sjú lingum meǒsý kursy ki af tegund 2
Laeknabladid
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.
Nature genetics
[Foot disease in Icelandic patients with established type 2 diabetes].
Laeknabladid
2007
Infant feeding patterns and midlife erythrocyte sedimentation rate.
Acta paediatrica (Oslo, Norway : 1992)
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.
Nature genetics
Outcomes of educational interventions in type 2 diabetes: WEKA data-mining analysis.
Patient education and counseling
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
Nature genetics
Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes.
Current medical research and opinion
[Prevalence of type 2 diabetes mellitus in Iceland 1967-2002].
Laeknabladid
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
Nature genetics
Prevalence of type 2 diabetes mellitus in Iceland 1967-2002,Algengi sykursýki af tegund tvö á Islandi 1967-2002.
Læknabladid
2006
Reliability and validity of the Icelandic version of the Problem Area in Diabetes (PAID) Scale.
International journal of nursing studies
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
Nature genetics
2005
Latent autoimmune diabetes in adults in Iceland: prevalence, phenotype and relatedness,Mótefnatengd sykursýki af tegund 2 á Islandi: algengi, svipgerd og skyldleiki einstaklinga.
Læknabladid
Mótefnatengd sykursýki af tegund 2 á Íslandi : algengi, svipgerð og skyldleiki einstaklinga
[Latent autoimmune diabetes in adults in Iceland: prevalence, phenotype and relatedness].
Laeknabladid
2004
Maximizing the benefit of treatment in mild hypertension:three simple steps to improve diagnostic accuracy.
QJM : monthly journal of the Association of Physicians
Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population.
European journal of clinical nutrition
2003
[Three simple steps for improving diagnostic accuracy in hypertension.].
Laeknabladid
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.
American journal of human genetics
2002
[Hypertension with hypokalemia: unusual presentation of pheochromocytoma - case report.].
Laeknabladid
Relationship between size at birth and hypertension in a genetically homogeneous population of high birth weight.
Journal of hypertension
Size at birth and coronary artery disease in a population with high birth weight
American Journal of Clinical Nutrition
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population.
The American journal of clinical nutrition
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population
American Journal of Clinical Nutrition
Size at birth and coronary artery disease in a population with high birth weight.
The American journal of clinical nutrition
2000
Transfer and metabolism of prostaglandin E(2)in the dual perfused human placenta.
Placenta
1998
Meðferð sykursýki af tegund 2 : bresk tímamótarannsókn styður góða blóðsykur- og blóðþrýstingsstjórn [ritstjórnargrein]
Understanding human parturition.
Lancet (London, England)
Understanding human parturition [6]
Lancet
Tissue-specific messenger ribonucleic acid expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid action.
Endocrinology
Management of the unexpected result: compensated hypothyroidism.
Postgraduate medical journal
1997
Lack of effect of nicotine or ethanol on the activity of 11β- hydroxysteroid dehydrogenase type 2
Journal of Steroid Biochemistry and Molecular Biology
Lack of effect of nicotine or ethanol on the activity of 11beta-hydroxysteroid dehydrogenase type 2.
The Journal of steroid biochemistry and molecular biology
Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure.
Clinical endocrinology
1996
11 beta-Hydroxysteroid dehydrogenases: tissue-specific dictators of glucocorticoid action.
Essays in biochemistry
11beta-Hydroxysteroid dehydrogenase type 2 in the rat corpus luteum: induction of messenger ribonucleic acid expression and bioactivity coincident with luteal regression.
Endocrinology
11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects.
Steroids
11β-Hydroxysteroid dehydrogenases: Key enzymes in determining tissue-specific glucocorticoid effects
Steroids
Essential hypertension: should we operate?
Clinical endocrinology
Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat
Placenta
11β-Hydroxysteroid dehydrogenases: Tissue-specific dictators of glucocorticoid action
Essays in Biochemistry
Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat.
Placenta
11beta-Hydroxysteroid dehydrogenase type 2 in the rat corpus luteum: induction of messenger ribonucleic acid expression and bioactivity coincident with luteal regression.
Endocrinology
1995
Ambulatory blood pressure monitoring: from research to clinical practice.
Journal of human hypertension
Fetal osteocalcin levels are related to placental 11 beta-hydroxysteroid dehydrogenase activity in humans.
Clinical endocrinology
Cellular selectivity of aldosterone action: Role of 11 beta-hydroxysteroid dehydrogenase
Current Opinion in Nephrology and Hypertension
Placental 11β-hydroxysteroid dehydrogenase and the programming of hypertension
Journal of Steroid Biochemistry and Molecular Biology
The role of 11beta-hydroxysteroid dehydrogenase in controlling foetal glucocorticoid exposure
Placental 11 beta-hydroxysteroid dehydrogenase and the programming of hypertension.
The Journal of steroid biochemistry and molecular biology
Ambulatory blood pressure monitoring: From research to clinical practice
Journal of Human Hypertension
Cellular selectivity of aldosterone action: role of 11 beta-hydroxysteroid dehydrogenase.
Current opinion in nephrology and hypertension
1994
Apparent mineralocorticoid excess.
Journal of human hypertension
Apparent mineralocorticoid excess
Journal of Human Hypertension
1993
Glucocorticoid exposure in utero: new model for adult hypertension.
Lancet (London, England)
Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?
The Lancet
Congenital and acquired syndromes of apparent mineralocorticoid excess.
The Journal of steroid biochemistry and molecular biology
Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?
Lancet (London, England)
Congenital and acquired syndromes of apparent mineralocorticoid excess
Journal of Steroid Biochemistry and Molecular Biology
1992
11β-Hydroxysteroid dehydrogenase in the rat ovary: High expression in the oocyte
Journal of Endocrinology
Dexamethasone treatment of pregnant rats leads to raised blood pressure in the offspring
Journal of Hypertension
11 beta-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte.
The Journal of endocrinology
Blood pressure and birth weight: Is fetal glucocorticoid exposure the missing link?
Journal of Hypertension
1991
Natural history of chronic left ventricular aneurysm; a population based cohort study.
Journal of clinical epidemiology
Natural history of chronic left ventricular aneurysm; A population based cohort study
Journal of Clinical Epidemiology
Liquorice.
Lancet (London, England)
1989
Áhrif lýsis á hjarta- og æðasjúkdóma.
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