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Pétur Snæbjörnsson - Professor

Pétur Snæbjörnsson

–

School of Health Sciences

Pétur Snæbjörnsson

Professor

Pathology of cancer of the digestive tract and cancer of unknown primary

Email
peturs [at] hi.is

Unit
Faculty of Medicine

Published works

2024

Efficacy-effectiveness analysis on survival in a population-based real-world study of BRAF-mutated metastatic colorectal cancer patients treated with encorafenib-cetuximabBritish Journal of Cancer
Imaging in the era of risk-adapted treatment in colon cancerThe British journal of radiology
Staging peritoneal metastases in colorectal cancerEuropean Journal of Surgical Oncology
Identifying the primary tumour in patients with cancer of unknown primary (CUP) using [¹⁸F]FDG PET/CTEuropean Journal of Nuclear Medicine and Molecular Imaging
Prolonged Time to Surgery in Patients with Residual Disease after Neoadjuvant Chemoradiotherapy for Esophageal CancerAnnals of Surgery
Characterization of discordance between mismatch repair deficiency and microsatellite instability testing may prevent inappropriate treatment with immunotherapyJournal of Pathology
Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair–Deficient Colon CancerNew England Journal of Medicine
Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment StrategyCancer Discovery
Non-invasive CT radiomic biomarkers predict microsatellite stability status in colorectal cancerEuropean radiology experimental
The mode of circumferential margin involvement in rectal cancer determines its impact on outcomesEuropean Journal of Surgical Oncology
Adjuvant Hyperthermic Intraperitoneal Chemotherapy in Patients With Locally Advanced Colon Cancer (COLOPEC)Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Hepatic arterial infusion pump chemotherapy combined with systemic chemotherapy for borderline resectable and unresectable colorectal liver metastasesBritish Journal of Surgery
Investigating locations of recurrences with MRI after CRS-HIPEC for colorectal peritoneal metastasesEuropean Journal of Radiology
Improving diagnostic accuracy of identifying gastric cancer patients with peritoneal metastasesOncogene
Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastasesCell Reports Medicine

2023

Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR)BMJ Open
MRI anatomy of the rectumInsights into Imaging
Correction: Groen et al. Use of Image-Guided Surgical Navigation during Resection of Locally Recurrent Rectal Cancer.
Life 2022,
12, 645.Life
Size and depth of residual tumor after neoadjuvant chemoradiotherapy in rectal cancer – implications for the development of new imaging modalities for response assessmentFrontiers in Oncology
Trends in epidemiology and primary treatment of anal squamous cell carcinoma in the Netherlands (1990–2021)International Journal of Cancer
Prevalence of neoplasia at colonoscopy among testicular cancer survivors treated with platinum-based chemotherapyInternational Journal of Cancer
The clinical impact of testing for biomarkers in gastric cancer patientsHistopathology
Development and multicenter validation of a multiparametric imaging model to predict treatment response in rectal cancerEuropean Radiology
International consensus on the initial diagnostic workup of cancer of unknown primaryCritical Reviews in Oncology/Hematology
Correlation of radiological and histopathological response after neoadjuvant radiotherapy in soft tissue sarcomaActa Oncologica

2022

Clinicopathological features and risk factors for developing colorectal neoplasia in Hodgkin’s lymphoma survivorsDigestive Endoscopy
Outcomes of patients with perforated colon cancerEuropean Journal of Surgical Oncology
Adhesion formation after surgery for locally advanced colonic cancer in the COLOPEC trialBJS open
Characteristics of tumour stroma in regional lymph node metastases in colorectal cancer patientsClinical and Translational Oncology
Use of Image-Guided Surgical Navigation during Resection of Locally Recurrent Rectal CancerLife
Neoadjuvant FOLFOXIRI prior to chemoradiotherapy for high-risk (“ugly”) locally advanced rectal cancerBMC Cancer
Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnosticsESMO Open
Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic RadiotherapyCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Molecular characterization of gastric adenocarcinoma diagnosed in patients previously treated for Hodgkin lymphoma or testicular cancerPLoS ONE
Current controversies in TNM for the radiological staging of rectal cancer and how to deal with themEuropean Radiology
Diagnostic performance of MRI for staging peritoneal metastases in patients with colorectal cancer after neoadjuvant chemotherapyEuropean Journal of Radiology
Metachronous peritoneal metastases in patients with pT4b colon cancerEuropean Journal of Surgical Oncology
Somatic hits in mismatch repair genes in colorectal cancer among non-seminoma testicular cancer survivorsBritish Journal of Cancer
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma PatientsCancers
The measured distance between tumor cells and the peritoneal surface predicts the risk of peritoneal metastases and offers an objective means to differentiate between pT3 and pT4a colon cancerModern Pathology

2021

Histopathological diagnosis of tumour deposits in colorectal cancerHistopathology
Detection of tumor-derived cell-free DNA from colorectal cancer peritoneal metastases in plasma and peritoneal fluidJournal of Pathology: Clinical Research
Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancerBJS open
Compliance with mismatch repair testing in pT1 colorectal cancer diagnosed before the age of 70 yearsVirchows Archiv
Comment on variability in synoptic reporting of colorectal cancer pT4a category and lymphovascular invasionArchives of Pathology and Laboratory Medicine
Tumor characteristics and clinical outcome of peritoneal metastasis of gastric origin treated with a hyperthermic intraperitoneal chemotherapy procedure in the PERISCOPE I trialJournal of Surgical Oncology
Risk of metachronous peritoneal metastases in patients with pT4a versus pT4b colon cancerEuropean Journal of Surgical Oncology
Cutaneous squamous cell carcinoma is associated with Lynch syndromeBritish Journal of Dermatology
High CD8⁺ tumour-infiltrating lymphocyte density associates with unfavourable prognosis in oesophageal adenocarcinoma following poor response to neoadjuvant chemoradiotherapyHistopathology
Location of gastrointestinal stromal tumor (GIST) in the stomach predicts tumor mutation profile and drug sensitivityClinical Cancer Research
Response to "cytomegalovirus Enterocolitis in a Patient with Refractory Immune-Related Colitis"Case Reports in Gastroenterology
Diagnostic yield of colonoscopy surveillance in testicular cancer survivors treated with platinum-based chemotherapyBMC Gastroenterology
Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal MetastasesJAMA Surgery
Prospective experimental treatment of colorectal cancer patients based on organoid drug responsesESMO Open

2020

Interobserver, intraobserver, and interlaboratory variability in reporting pT4a colon cancerVirchows Archiv
Diagnostic accuracy of stool tests for colorectal cancer surveillance in hodgkin lymphoma survivorsJournal of Clinical Medicine
The metastatic pattern of intestinal and diffuse type gastric carcinoma – A Dutch national cohort studyCancer Epidemiology
Cytomegalovirus in Steroid-Refractory Immune Checkpoint Inhibition–Related ColitisJournal of Thoracic Oncology
A population-based study on intestinal and diffuse type adenocarcinoma of the oesophagus and stomach in the Netherlands between 1989 and 2015European Journal of Cancer
Gene expression profiles of esophageal squamous cell cancers in Hodgkin lymphoma survivors versus sporadic casesPLoS ONE
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancersNature Medicine
Gastroscopic surveillance with targeted biopsies compared with random biopsies in CDH1 mutation carriersEndoscopy

2019

Molecular profiling of longitudinally observed small colorectal polypsEBioMedicine
Factors influencing long-term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei originating from appendiceal neoplasmsBJS open
Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patientsScience Translational Medicine
Overall and disease-specific survival of Hodgkin lymphoma survivors who subsequently developed gastrointestinal cancerCancer Medicine
High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivorsCancer
Diagnostic performance of MRI for assessment of response to neoadjuvant chemoradiotherapy in oesophageal cancerBritish Journal of Surgery
Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancersNature Medicine
Second and third look laparoscopy in pT4 colon cancer patients for early detection of peritoneal metastases; The COLOPEC 2 randomized multicentre trialBMC Cancer
Elevated pretreatment CEA and CA19-9 levels are related to early treatment failure in esophageal adenocarcinomaAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC)The Lancet Gastroenterology and Hepatology
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy versus palliative systemic chemotherapy in stomach cancer patients with peritoneal dissemination, the study protocol of a multicentre randomised controlled trial (PERISCOPE II)BMC Cancer
Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastasesBMC Cancer
A squamous cell carcinoma in a young woman with Lynch syndromeFamilial Cancer

2018

Outcomes of screening gastroscopy in first-degree relatives of patients fulfilling hereditary diffuse gastric cancer criteriaGastrointestinal Endoscopy
Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancerBMC Cancer
Histopathological and molecular classification of colorectal cancer and corresponding peritoneal metastasesBritish Journal of Surgery
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor OrganoidsCell
Advanced Age is Not a Contraindication for Treatment with Curative Intent in Esophageal CancerAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Immune checkpoint inhibition-related colitisESMO Open
Outcomes after prophylactic gastrectomy for hereditary diffuse gastric cancerBritish Journal of Surgery
Using textbook outcome as a measure of quality of care in oesophagogastric cancer surgeryBritish Journal of Surgery
Double somatic mutations in mismatch repair genes are frequent in colorectal cancer after Hodgkin's lymphoma treatmentGut

2017

Profound immunotherapy response in mismatch repair-deficient breast cancerJCO Precision Oncology
Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancerOncotarget
Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancerBMC Cancer
Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgeryJournal of Biomedical Optics
The prognostic and potentially predictive value of the Laurén classification in oesophageal adenocarcinomaEuropean Journal of Cancer

2016

WRN promoter CpG island hypermethylation does not predict more favorable outcomes for patients with metastatic colorectal cancer treated with irinotecan-based therapyClinical Cancer Research
Real-time in vivo assessment of radiofrequency ablation of human colorectal liver metastases using diffuse reflectance spectroscopyEuropean Journal of Surgical Oncology
Prognostic value of BRAF and KRAS mutation status in stage II and III microsatellite instable colon cancersInternational Journal of Cancer

2015

Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trialBMC Cancer

2013

The chameleon of neuroinflammationMultiple Sclerosis Journal

Keywords for Specialisation:

Molecular pathology

Colorectal cancer

Appendiceal cancer

Cancer of the gastrointestinal tract

Cancer of unknown primary

Peritoneal metastases

Whole genome sequencing (WGS)