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Forsíða

Óttar Rolfsson - Professor

Óttar Rolfsson

–

School of Health Sciences

Óttar Rolfsson

Professor

of Biochemistry and Systems Biology

Location
Sturlugata 8
Phone
525 - 5854
Email
ottarr [at] hi.is

Unit
Biochemistry
Website
https://systemsbiology.hi.is/the-rolfsson-laboratory/

Published works

2024

Temperature Dependence of Platelet MetabolismMetabolites
LASSO regression shows histidine and sphingosine 1 phosphate are linked to both sepsis mortality and endothelial damageEuropean Journal of Medical Research
ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy MetabolismTraffic

2023

Endothelial Cell Phenotypes Demonstrate Different Metabolic Patterns and Predict Mortality in Trauma PatientsInternational Journal of Molecular Sciences
Fish Skin Grafts Affect Adenosine and Methionine Metabolism during Burn Wound HealingAntioxidants

2022

Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative StressMolecular and Cellular Proteomics
The Anti-Proliferative Lichen-Compound Protolichesterinic Acid Inhibits Oxidative Phosphorylation and Is Processed via the Mercapturic Pathway in Cancer CellsPlanta Medica
Protein Concentrations in Stored Pooled Platelet Concentrates Treated with Pathogen Inactivation by Amotosalen Plus Ultraviolet a IlluminationPathogens
Metabolic Response in Endothelial Cells to Catecholamine Stimulation Associated with Increased Vascular PermeabilityInternational Journal of Molecular Sciences
Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of TraumaInternational Journal of Molecular Sciences
UDP-glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell linesMolecular Oncology

2021

Lipid mediator profiles of burn wound healingProstaglandins Leukotrienes and Essential Fatty Acids
Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model ReconstructionFrontiers in Cell and Developmental Biology
Metabolic and Transcriptional Changes across Osteogenic Differentiation of Mesenchymal Stromal Cells.Bioengineering (Basel, Switzerland)
The Anti-Proliferative Lichen-Compound Protolichesterinic Acid Inhibits Oxidative Phosphorylation and Is Processed via the Mercapturic Pathway in Cancer CellsPlanta Medica
Cerebrospinal Fluid C18 Ceramide Associates with Markers of Alzheimer's Disease and Inflammation at the Pre- And Early Stages of DementiaJournal of Alzheimer's Disease
EMT-derived alterations in glutamine metabolism sensitize mesenchymal breast cells to mTOR inhibitionMolecular Cancer Research
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancernpj Systems Biology and Applications
Metabolic and transcriptional changes across osteogenic differentiation of mesenchymal stromal cellsBioengineering
Analyzing Metabolic States of Adipogenic and Osteogenic Differentiation in Human Mesenchymal Stem Cells via Genome Scale Metabolic Model Reconstruction.Frontiers in Cell and Developmental Biology

2020

Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine.Frontiers in Bioengineering and Biotechnology
Metabolomics study of platelet concentrates photochemically treated with amotosalen and UVA light for pathogen inactivationTransfusion
Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative MedicineFrontiers in Bioengineering and Biotechnology
Visualizing metabolic network dynamics through time-series metabolomic dataBMC Bioinformatics
Metabolic Systems Analysis of Shock-Induced Endotheliopathy (SHINE) in TraumaAnnals of Surgery
Wound healing graftsJournal of Tissue Engineering and Regenerative Medicine
Visualizing metabolic network dynamics through time-series metabolomic data.BMC Bioinformatics
ECM1 secreted by HER2-overexpressing breast cancer cells promotes formation of a vascular niche accelerating cancer cell migration and invasionLaboratory Investigation
Metabolomics study of platelet concentrates photochemically treated with amotosalen and UVA light for pathogen inactivationTransfusion
Comparative metabolic network flux analysis to identify differences in cellular metabolism

2019

Combined artificial high-silicate medium and LED illumination promote carotenoid accumulation in the marine diatom Phaeodactylum tricornutumMicrobial Cell Factories
Azithromycin induces epidermal differentiation and multivesicular bodies in airway epitheliaRespiratory Research
Pathogen inactivation with amotosalen plus UVA illumination minimally impacts microRNA expression in platelets during storage under standard blood banking conditionsTransfusion
Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia.Respiratory Research

2018

Ion mobility-derived collision cross section databaseAnalytica Chimica Acta
Systems analysis of metabolism in platelet concentrates during storage in platelet additive solutionBiochemical Journal
Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratificationScientific Reports
Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutumMarine Drugs
Altered plasmalogen content and fatty acid saturation following epithelial to mesenchymal transition in breast epithelial cell linesInternational Journal of Biochemistry and Cell Biology
Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification.Scientific Reports

2017

Mannose and fructose metabolism in red blood cells during cold storage in SAGMTransfusion
Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomicsScientific Reports
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition.Cancer Letters
Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics.Scientific Reports
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transitionCancer Letters
Regenerative and antibacterial properties of acellular fish skin grafts and human amnion/chorion membraneMilitary Medicine
Quantitative time-course metabolomics in human red blood cells reveal the temperature dependence of human metabolic networksJournal of Biological Chemistry
Mannose and fructose metabolism in red blood cells during cold storage in SAGMTransfusion
Metabolomics comparison of red cells stored in four additive solutions reveals differences in citrate anticoagulant permeability and metabolismVox Sanguinis
Quantitative time-course metabolomics in human red blood cells reveal the temperature dependence of human metabolic networksJournal of Biological Chemistry

2016

Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomesTransfusion
Biomarkers defining the metabolic age of red blood cells during cold storageBlood
Metabolic fate of adenine in red blood cells during storage in SAGM solutionTransfusion
Direct Evidence for Packaging Signal-Mediated Assembly of Bacteriophage MS2Journal of Molecular Biology
Metabolic Analysis of Red Blood Cells Stored at High TemperatureBlood
Acceleration of Wound Healing Through Utilization of Fish Skin Containing Omega-3 Fatty Acids.Today´s Wound Clinic
EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMTPLoS Computational Biology
Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomesTransfusion
Understanding the Causes and Implications of Endothelial Metabolic Variation in Cardiovascular Disease through Genome-Scale Metabolic ModelingFrontiers in Cardiovascular Medicine

2015

Affrumað roð: Eðliseiginleikar sem styðja vefjaviðgerðLæknablaðið
Affrumad rodLaeknabladid
Prediction of intracellular metabolic states from extracellular metabolomic dataMetabolomics
Decoding the jargon of bottom-up metabolic systems biologyBioEssays
Metabolomic analysis of platelets during storageTransfusion
Kinetic analysis of gluconate phosphorylation by human gluconokinase using isothermal titration calorimetryFEBS Letters

2014

Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storageTransfusion
Ion mobility derived collision cross sections to support metabolomics applicationsAnalytical Chemistry
Biochemical characterization of human gluconokinase and the proposed metabolic impact of gluconic acid as determined by constraint based metabolic network analysisPLoS ONE

2013

A community-driven global reconstruction of human metabolismNature Biotechnology
Inferring the metabolism of human orphan metabolites from their metabolic network context affirms human gluconokinase activityBiochemical Journal

2011

The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functionsBMC Systems Biology

2010

Mutually-induced conformational switching of RNA and coat protein underpins efficient assembly of a viral capsidJournal of Molecular Biology
Viral Genomic Single-Stranded RNA Directs the Pathway Toward a T = 3 CapsidJournal of Molecular Biology

2008

RNA packing specificity and folding during assembly of the bacteriophage MS2Computational and Mathematical Methods in Medicine

2007

A Simple, RNA-Mediated Allosteric Switch Controls the Pathway to Formation of a T = 3 Viral CapsidJournal of Molecular Biology

2003

Linkage of osteoporosis to chromosome 20p12 and association to BMP2PLoS Biology

Keywords for Specialisation:

Clinical Biochemistry

Cancer metabolism

Vascular endothelium