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Forsíða

Margrét Helga Ögmundsdóttir - Professor

Margrét Helga Ögmundsdóttir

–

School of Health Sciences

Margrét Helga Ögmundsdóttir

Professor

Cell Biology

Location
Sturlugata 8
Email
mho [at] hi.is

Unit
Anatomy

Published works

2024

ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy MetabolismTraffic

2022

The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial CellsJournal of Innate Immunity
Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62Scientific Reports
A novel region within a conserved domain in ATG7 emerged in vertebratesAutophagy Reports

2021

Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy
Mitf reprograms the extracellular matrix and focal adhesion in melanomaeLife

2020

Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motifNucleic Acids Research
MITF and TFEB cross-regulation in melanoma cellsPLoS ONE
Use of proton pump inhibitors and mortality among Icelandic patients with prostate cancerBasic and Clinical Pharmacology and Toxicology
NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery diseaseScientific Reports
NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery diseaseScientific Reports

2019

Subcellular localization and stability of MITF are modulated by the bHLH-Zip domainPigment Cell and Melanoma Research
The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye functionScientific Reports
MITF has a central role in regulating starvation-induced autophagy in melanomaScientific Reports
The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye functionScientific Reports
Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanomaPharmacoepidemiology and Drug Safety
MITF has a central role in regulating starvation-induced autophagy in melanomaScientific Reports

2018

Erratum toScientific Reports
Proton-pump inhibitors among adultsTherapeutic Advances in Gastroenterology
A short isoform of ATG7 fails to lipidate LC3/GABARAPScientific Reports

2017

Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growthScience

2016

Nóbelsverðlaunin í læknavísindum í ár endurspegla mikilvægi sorphirðu og endurvinnsluLaeknabladid
Nóbelsverolaunin í læknavísindum í ár endurspegla mikilvægi sorphirou og endurvinnsluLaeknabladid
Nóbelsverðlaunin í læknavísindum í ár endurspegla mikilvægi sorphirðu og endurvinnsluLæknablaðið

2015

MITF regulation - more hints from WntPigment Cell and Melanoma Research
Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activityProstaglandins Leukotrienes and Essential Fatty Acids
Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1Journal of Cell Science

2014

Selection, p53, and pigmentation.Pigment cell & melanoma research

2013

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traitsNature
MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein functionHuman Molecular Genetics
XA polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathwayCell

2012

Sensitivity of BRCA2 mutated human cell lines to Aurora kinase inhibitionInvestigational New Drugs
Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITFGenes and Development
Proton-assisted Amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranesPLoS ONE
Proton-Shuttling Lichen Compound Usnic Acid Affects Mitochondrial and Lysosomal Function in Cancer CellsPLoS ONE

2010

Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activationOncogene

2009

Amino acid sensing and mTOR regulationBiochemical Society Transactions

2007

Duplicated sequence motif in the long terminal repeat of maedi-visna viras extends cell tropism and is associated with neurovirulenceJournal of Virology
Amino acid transporters and nutrient-sensing mechanismsBiochemical Society Transactions

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