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Margrét Helga Ögmundsdóttir - Professor
–
Heilbrigðisvísindasvið
Margrét Helga Ögmundsdóttir
Íslenska
Professor
Cell Biology
Location
Sturlugata 8
Email
mho [at] hi.is
Unit
Anatomy
ORCID site
https://orcid.org/0000-0003-2836-9988
Research portal – Margrét Helga Ögmundsdóttir
Courses 2024 - 2025
LÆK222G - Cell biology and genetics
LÆK092F - Biology of Cancer
LÍF315G - Cell Biology
MON204G - General Cell Biology
Published works
2024
ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism
Traffic
2022
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells
Journal of Innate Immunity
Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62
Scientific Reports
A novel region within a conserved domain in ATG7 emerged in vertebrates
Autophagy Reports
2021
Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy
Mitf reprograms the extracellular matrix and focal adhesion in melanoma
eLife
2020
Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif
Nucleic Acids Research
MITF and TFEB cross-regulation in melanoma cells
PLoS ONE
Use of proton pump inhibitors and mortality among Icelandic patients with prostate cancer
Basic and Clinical Pharmacology and Toxicology
NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease
Scientific Reports
NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease
Scientific Reports
2019
Subcellular localization and stability of MITF are modulated by the bHLH-Zip domain
Pigment Cell and Melanoma Research
The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function
Scientific Reports
MITF has a central role in regulating starvation-induced autophagy in melanoma
Scientific Reports
The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function
Scientific Reports
Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma
Pharmacoepidemiology and Drug Safety
MITF has a central role in regulating starvation-induced autophagy in melanoma
Scientific Reports
2018
Erratum to
Scientific Reports
Proton-pump inhibitors among adults
Therapeutic Advances in Gastroenterology
A short isoform of ATG7 fails to lipidate LC3/GABARAP
Scientific Reports
2017
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
Science
2016
Nóbelsverðlaunin í læknavísindum í ár endurspegla mikilvægi sorphirðu og endurvinnslu
Laeknabladid
Nóbelsverolaunin í læknavísindum í ár endurspegla mikilvægi sorphirou og endurvinnslu
Laeknabladid
Nóbelsverðlaunin í læknavísindum í ár endurspegla mikilvægi sorphirðu og endurvinnslu
Læknablaðið
2015
MITF regulation - more hints from Wnt
Pigment Cell and Melanoma Research
Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activity
Prostaglandins Leukotrienes and Essential Fatty Acids
Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1
Journal of Cell Science
2014
Selection, p53, and pigmentation.
Pigment cell & melanoma research
2013
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
Nature
MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function
Human Molecular Genetics
XA polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway
Cell
2012
Sensitivity of BRCA2 mutated human cell lines to Aurora kinase inhibition
Investigational New Drugs
Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF
Genes and Development
Proton-assisted Amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
PLoS ONE
Proton-Shuttling Lichen Compound Usnic Acid Affects Mitochondrial and Lysosomal Function in Cancer Cells
PLoS ONE
2010
Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation
Oncogene
2009
Amino acid sensing and mTOR regulation
Biochemical Society Transactions
2007
Duplicated sequence motif in the long terminal repeat of maedi-visna viras extends cell tropism and is associated with neurovirulence
Journal of Virology
Amino acid transporters and nutrient-sensing mechanisms
Biochemical Society Transactions
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