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Forsíða

Margrét Þorsteinsdóttir - Professor

Margrét Þorsteinsdóttir

–

School of Health Sciences

Margrét Þorsteinsdóttir

Professor

Professor

Location
Sturlugata 8
Phone
525 - 5811
Email
margreth [at] hi.is

Unit
Faculty of Pharmaceutical Sciences

Published works

2024

Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standardsNature Communications
A critical review of the edible seaweed Palmaria palmata (L.) Weber & Mohr and its bioactive compounds in the “omics” eraAlgal Research
Optimization and validation of a UPLC-MS/MS assay for simultaneous quantification of 2,8-dihydroxyadenine, adenine, allopurinol, oxypurinol and febuxostat in human plasmaJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2023

Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro ApproachesMarine Drugs
Lipidomes of Icelandic bryophytes and screening of high contents of polyunsaturated fatty acids by using lipidomics approachPhytochemistry
Simplification of home urine sampling for measurement of 2,8-dihydroxyadenine in patients with adenine phosphoribosyltransferase deficiency
Effect of Environmental Physico-Chemical Parameters on the Biochemical Composition of Wild Icelandic Laminaria digitata and Saccharina latissima (Laminariaceae, Phaeophyceae)Regional Studies in Marine Science
Optimized LC-MS/MS Method for the Detection of ppCCK(21-44)Journal of Proteome Research

2022

Novel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichensPhytochemistry
Current kidney function parameters overestimate kidney tissue repair in reversible experimental kidney diseaseKidney International
Lipidomic analysis of moss species Bryum pseudotriquetrum and Physcomitrium patens under cold stressPlant-Environment Interactions
Automated Cancer Diagnostics via Analysis of Optical and Chemical Images by Deep and Shallow LearningMetabolites

2021

Performance Assessment of a 125 Human Plasma Peptide Mixture Stored at Room Temperature for Multiple Reaction Monitoring-Mass SpectrometryJournal of Proteome Research
Natural Products from BryophytesCritical Reviews in Plant Sciences
Design of experiments for development and optimization of a liquid chromatography coupled to tandem mass spectrometry bioanalytical assayJournal of Mass Spectrometry
The effect of sample age on the metabolic information extracted from formalin-fixed and paraffin embedded tissue samples using desorption electrospray ionization mass spectrometry imagingJournal of Mass Spectrometry and Advances in the Clinical Lab
Effects of extraction parameters on lipid profiling of mosses using UPLC-ESI-QTOF-MS and multivariate data analysisMetabolomics

2020

Lipidomic study of cell lines reveals differences between breast cancer subtypesPLoS ONE
Lipidomic study of cell lines reveals lipid biomarkers for breast cancer subtypesPLoS ONE
Two new spongian diterpene analogues isolated from the marine sponge Acanthodendrilla spNatural Product Research
Cellular and molecular mechanisms of kidney injury in 2,8-dihydroxyadenine nephropathyJournal of the American Society of Nephrology
Genetic variability in the absorption of dietary sterols affects the risk of coronary artery diseaseEuropean Heart Journal
Genetic variability in the uptake of dietary sterols affects the risk of coronary artery diseaseEuropean Heart Journal

2019

Identification of Cyanobacterial Strains with Potential for the Treatment of Obesity-Related Co-Morbidities by Bioactivity, Toxicity Evaluation and Metabolite ProfilingMarine Drugs
Alkaloid fingerprinting resolves Huperzia selago genotypes in IcelandBiochemical Systematics and Ecology
Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritisKidney International
Determining gradient conditions for peptide purification in RPLC with machine-learning-based retention time predictionsJournal of Chromatography A
New Aromatic Bisabolane Derivatives with Lipid-Reducing Activity from the Marine Sponge Myrmekioderma sp.Marine Drugs
Alkaloids fingerprinting resolves Huperzia selago genotypes in Iceland.Biochemical Systematics and Ecology
Valuable fatty acids in bryophytes—production, biosynthesis, analysis and applicationsPlants
Urinary 2,8-dihydroxyadenine excretion in patients with adenine phosphoribosyltransferase deficiency, carriers and healthy control subjectsMolecular Genetics and Metabolism

2018

Untargeted metabolic profiling reveals geography as the strongest predictor of metabolic phenotypes of a cosmopolitan weedEcology and Evolution
Comparison of the effect of allopurinol and febuxostat on urinary 2,8-dihydroxyadenine excretion in patients with Adenine phosphoribosyltransferase deficiency (APRTd)European Journal of Internal Medicine
Altered plasmalogen content and fatty acid saturation following epithelial to mesenchymal transition in breast epithelial cell linesInternational Journal of Biochemistry and Cell Biology
Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS chemical profiling and DNA barcodingFood Chemistry
Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS metabolite profiling and DNA barcoding.Food Chemistry
Topical drug delivery to the posterior segment of the eyeJournal of Drug Delivery Science and Technology
To wash or not to wash? Comparison of patient outcome after infusion of cryopreserved autologous hematopoietic stem cells before and after the replacement of manual washing by bedside thawingActa Haematologica
Method Development by Design of Experiments for Quantification of Lipoxygenase Metabolites in Human Cancer Cells with UPLC-MS/MS.SM Analytical and Bioanalytical Techniques
Authentication of Iceland Moss by UPLC-QToF-MS chemical profiling and DNA barcoding.Food Chemistry
Corrigendum to “Quantitative UPLC–MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiency” [J. Chromatogr. B 1036–1037 (2016) 170–177] (S1570023216308467) (10.1016/j.jchromb.2016.09.018))Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago ComplexPlanta Medica

2017

Metabolic profiling as a screening tool for cytotoxic compoundsMarine Drugs
DNA barcoding and LC-MS metabolite profiling of the lichen-forming genus Melanelia: Specimen identification and discrimination focusing on Icelandic taxaPLoS ONE
Metabolic profiling as screening tool for cytotoxic compounds: Identification of 3-alkyl pyridine alkaloids from sponges collected at a submarine hydrothermal vent site.Marine Drugs
Metabolic Profiling as a Screening Tool for Cytotoxic Compounds: Identification of 3-Alkyl Pyridine Alkaloids from Sponges Collected at a Shallow Water Hydrothermal Vent Site North of IcelandMarine Drugs
New Fluvirucinins C₁ and C₂ Produced by a Marine Derived ActinomyceteNatural Product Communications

2016

Protolichesterinic Acid, Isolated from the Lichen Cetraria islandica, Reduces LRRC8A Expression and Volume-Sensitive Release of Organic Osmolytes in Human Lung Epithelial Cancer CellsPhytotherapy Research
Quantitative UPLC–MS/MS assay of urinary 2,8-dihydroxyadenine for diagnosis and management of adenine phosphoribosyltransferase deficiencyJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

2015

Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activityProstaglandins Leukotrienes and Essential Fatty Acids

2014

Kinetics of γ-cyclodextrin nanoparticle suspension eye drops in tear fluidActa Ophthalmologica
Kinetics of γ-cyclodextrin nanoparticle suspension eye drops in tear fluidActa Ophthalmologica
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31Nature Genetics

2013

Dexamethasone eye drops containing γ-cyclodextrin-based nanogelsInternational Journal of Pharmaceutics

2012

Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS

2010

Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding.Journal of Medicinal Chemistry
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safetyNature Biotechnology
Cyclodextrin solubilization of carbonic anhydrase inhibitor drugsEuropean Journal of Pharmaceutics and Biopharmaceutics
Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis.Journal of Medicinal Chemistry

2009

Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophyHuman Molecular Genetics
Antagonists of the EP₃ receptor for prostaglandin e₂ are novel antiplatelet agents that do not prolong bleedingACS Chemical Biology

2008

Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophyJournal of Medicinal Chemistry

2005

Cyclodextrin formulation of dorzolamide and its distribution in the eye after topical administrationJournal of Controlled Release

1999

Multivariate evaluation of organic modifier effects on the separation performance of peptides in micellar electrokinetic chromatograpbyJournal of Chromatography A

1998

Multivariate evaluation of the separation performance in micellar electrokinetic capillary chromatography of peptidesChromatographia
Chemometric evaluation of the band broadening in micellar electrokinetic chromatography of peptidesJournal of Chromatography A

1997

Multivariate evaluation of the separation performance in micellar electrokinetic capillary chromatography of peptidesChromatographia

1996

Peak compression and deformation caused by large system peaks in HPLC, part IILC GC Europe
Peak compression and deformation caused by large system peaks in HPLCLC GC Europe

1995

Performance of amino‐silylated fused‐silica capillaries for the separation of enkephalin‐related peptides by capillary zone electrophoresis and micellar electrokinetic chromatographyElectrophoresis
Capillary electroseparations of enkephalin‐related peptides and protein kinase A peptide substratesElectrophoresis

Keywords for Specialisation:

Analytical pharmaceutical chemistry. Main research is focused on separation science

Clinical mass spectrometry

Targeted Proteomics