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Forsíða

Jón Þór Bergþórsson - Associate Professor

Jón Þór Bergþórsson

–

School of Health Sciences

Jón Þór Bergþórsson

Associate Professor

Location
LSH - Hringbraut
Email
jthb1 [at] hi.is

Unit
Geisla- og lífeindafræði

ORCID site
https://orcid.org/0000-0002-0560-2639
Research portal – Jón Þór Bergþórsson
Under construction throughout the autumn semester 2023

Published works

2020

Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells.Frontiers in cell and developmental biology
The BLIMP1-EZH2 nexus in a non-Hodgkin lymphoma.Oncogene
Transforming growth factor β-mediated micromechanics modulates disease progression in primary myelofibrosis.Journal of cellular and molecular medicine
Melflufen, a peptide-conjugated alkylator, is an efficient anti-neo-plastic drug in breast cancer cell lines.Cancer medicine

2016

Epithelial Plasticity During Human Breast Morphogenesis and Cancer Progression.Journal of mammary gland biology and neoplasia

2015

MicroRNA-200c-141 and ∆Np63 are required for breast epithelial differentiation and branching morphogenesis.Developmental biology

2014

deltaNp63 has a role in maintaining epithelial integrity in airway epithelium.PloS one
Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia.Genes

2013

Endothelial-rich microenvironment supports growth and branching morphogenesis of prostate epithelial cells.The Prostate

2009

Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.Nature genetics

2008

Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.Nature genetics
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.Nature genetics
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer.Nature genetics
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.Nature
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.Nature genetics

2007

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.Nature genetics
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.Nature genetics
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.Nature genetics

2006

A common variant associated with prostate cancer in European and African populations.Nature genetics
Testicular germ cell tumours in Iceland: a nationwide clinicopathological study.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
The BARD1 Cys557Ser variant and breast cancer risk in Iceland.PLoS medicine
A genome-wide study of allelic imbalance in human testicular germ cell tumors using microsatellite markers.Cancer genetics and cytogenetics

2003

A population-based analysis of increased incidence and improved survival of testicular cancer patients in Iceland.Scandinavian journal of urology and nephrology

2002

Mutation analysis of the CHK2 gene in breast carcinoma and other cancers.Breast cancer research : BCR
High frequency of LOH, MSI and abnormal expression of FHIT in gastric cancer.European journal of cancer (Oxford, England : 1990)
A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes.Human genetics

2001

Functional analysis of BRCA1 C-terminal missense mutations identified in breast and ovarian cancer families.Human molecular genetics
BRCA1 and BRCA2 mutation status and cancer family history of Danish women affected with multifocal or bilateral breast cancer at a young age.Journal of medical genetics

2000

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus.Proceedings of the National Academy of Sciences of the United States of America
Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer.Human genetics
The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences.International journal of oncology

1999

Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables.Anticancer research
Mutations of the BRCA1 and BRCA2 Genes in Danish Patients Diagnosed at Young Age with Multi-Centric or Bilateral Breast Cancer.Disease markers

1998

Identification of a novel splice-site mutation of the BRCA1 gene in two breast cancer families: screening reveals low frequency in Icelandic breast cancer patients.Human mutation
A population study of mutations and LOH at breast cancer gene loci in tumours from sister pairs: two recurrent mutations seem to account for all BRCA1/BRCA2 linked breast cancer in Iceland.Journal of medical genetics
Chromosome imbalance at the 3p14 region in human breast tumours: high frequency in patients with inherited predisposition due to BRCA2.European journal of cancer (Oxford, England : 1990)

1996

High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients.Cancer research
Frequent occurrence of BRCA2 linkage in Icelandic breast cancer families and segregation of a common BRCA2 haplotype.American Journal of Human Genetics

1995

Loss of heterozygosity on chromosome 9 in human breast cancer: association with clinical variables and genetic changes at other chromosome regions.International journal of cancer
Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13.Cancer research
Linkage analysis and allelic imbalance in human breast cancer kindreds using microsatellite markers from the short arm of chromosome 3.Human genetics
Identification of a breast tumor with microsatellite instability in a potential carrier of the hereditary non-polyposis colon cancer trait.Clinical genetics
Mapping of chromosome-3 alterations in human breast-cancer using microsatellite PCR markers - correlation with clinical-variables.International journal of oncology

Keywords for Specialisation:

Hematology and laboratory hematology

Molecular Biology