Skip to main content

ÍS
EN

Forsíða

Forsíða

Ingibjörg Harðardóttir - Professor

Ingibjörg Harðardóttir

–

School of Health Sciences

Ingibjörg Harðardóttir

Professor

Professor of Biochemistry and Molecular Biology

Location
Læknagarður / Lg-535
Phone
525 - 4885
Email
ih [at] hi.is

Unit
Biochemistry
Website
http://lifvisindi.hi.is/staff/ingibjorg-hardardottir

ORCID site
https://orcid.org/0000-0003-0178-7047
Research portal – Ingibjörg Harðardóttir
Under construction throughout the autumn semester 2023

Published works

2023

Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barrettiMolecules

2022

Dietary Fish Oil Increases the Number of CD11b+ CD27- NK Cells at the Inflammatory Site and Enhances Key Hallmarks of Resolution of Murine Antigen-Induced PeritonitisJournal of Inflammation Research
Dietary Fish Oil Increases the Number of CD11b⁺CD27⁻ NK Cells at the Inflammatory Site and Enhances Key Hallmarks of Resolution of Murine Antigen-Induced PeritonitisJournal of Inflammation Research

2021

Emu Oil and Saireito in combination reduce tumour development and clinical indicators of disease in a mouse model of colitis-associated colorectal cancerBiomedicine & Pharmacotherapy
Seaweed Extract Improves Carbohydrate Metabolism in Overweight and Obese AdultsCurrent Nutrition & Food Science

2020

The BLIMP1—EZH2 nexus in a non-Hodgkin lymphomaOncogene
Anti-inflammatory and proresolving effects of the omega-6 polyunsaturated fatty acid adrenic acidJournal of Immunology
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic AcidThe Journal of Immunology
Bromotryptamine and Imidazole Alkaloids with Anti-inflammatory Activity from the Bryozoan Flustra foliaceaJournal of Natural Products
Docosahexaenoic Acid Modulates NK Cell Effects on Neutrophils and Their CrosstalkFrontiers in Immunology

2019

Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes.International immunopharmacology

2018

6-Bromoindole Derivatives from the Icelandic Marine Sponge Geodia barretti: Isolation and Anti-Inflammatory ActivityMarine Drugs

2017

Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice.Molecular immunology
Lipophilic fractions from the marine sponge Halichondria sitiens decrease secretion of pro-inflammatory cytokines by dendritic cells and decrease their ability to induce a Th1 type response by allogeneic CD4+ T cells.Pharmaceutical biology

2016

A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytesCarbohydrate Polymers
Acute phase inflammation is characterized by rapid changes in plasma/peritoneal fluid N-glycosylation in miceGlycoconjugate Journal

2015

Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses toward a Th2/Treg phenotype.Phytomedicine : international journal of phytotherapy and phytopharmacology
Differential Mobility Separation of Leukotrienes and ProtectinsAnalytical Chemistry

2014

Murine antigen-induced inflammation--a model for studying induction, resolution and the adaptive phase of inflammation.Journal of immunological methods
Dietary omega-3 fatty acids enhance the B1 but not the B2 cell immune response in mice with antigen-induced peritonitisThe Journal of Nutritional Biochemistry
A heteroglycan from the cyanobacterium Nostoc commune modulates LPS-induced inflammatory cytokine secretion by THP-1 monocytes through phosphorylation of ERK1/2 and AktPhytomedicine

2013

Dietary fish oil reduces the acute inflammatory response and enhances resolution of antigen-induced peritonitisThe Journal of Nutritional Biochemistry
Dietary fish oil increases the proportion of a specific neutrophil subpopulation in blood and total neutrophils in peritoneum of mice following endotoxin-induced inflammation.The Journal of nutritional biochemistry

2012

Two circulating neutrophil populations in acute inflammation in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Dietary fish oil decreases the proportion of classical monocytes in blood in healthy mice but increases their proportion upon induction of inflammation.The Journal of nutrition

2011

Aqueous extracts from Menyanthes trifoliate and Achillea millefolium affect maturation of human dendritic cells and their activation of allogeneic CD4+ T cells in vitroJournal of Ethnopharmacology
Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitroImmunology Letters

2010

Immunomodulating effects of extracts from Icelandic marine invertebratesPlanta Medica

2009

Dietary fish oil decreases secretion of T helper (Th) 1-type cytokines by a direct effect on murine splenic T cells but enhances secretion of a Th2-type cytokine by an effect on accessory cellsBritish Journal of Nutrition

2008

The effects of dietary fish oil on chemokine secretion by murine peritoneal and spleen cellsProceedings of the Nutrition Society
The effects of dietary fish oil on chemokine secretion by murine peritoneal and spleen cellsProceedings of the Nutrition Society
Dietary fish oil decreases secretion of T helper (Th) 1-type cytokines by a direct effect on murine splenic T cells but enhances secretion of a Th2-type cytokine by an effect on accessory cellsBritish Journal of Nutrition
Dietary fish oil increases IL-4 secretion by murine splenocytes by an effect on accessory cellsProceedings of the Nutrition Society
Dietary fish oil increases IL-4 secretion by murine splenocytes by an effect on accessory cellsProceedings of the Nutrition Society

2007

Mucosal tolerance to KLH reduces BSA-induced arthritis in rats--an indication of bystander suppression.Journal of clinical immunology
The effects of omega-3 polyunsaturated fatty acids on TNF-alpha and IL-10 secretion by murine peritoneal cells in vitro.Lipids
Dietary fish oil increases the number of splenic macrophages secreting TNF-alpha and IL-10 but decreases the secretion of these cytokines by splenic T cells from mice.The Journal of nutrition
Positive association between DNA strand breaks in peripheral blood mononuclear cells and polyunsaturated fatty acids in red blood cells from women.Nutrition and cancer
Dietary fish oil increases the number of splenic macrophages secreting TNF-α and IL-10 but decreases the secretion of these cytokines by splenic T cells from miceJournal of Nutrition

2006

Positive association between plasma antioxidant capacity and n-3 PUFA in red blood cells from women.Lipids

2002

Dietary fish oil increases tumor necrosis factor secretion but decreases interleukin-10 secretion by murine peritoneal macrophagesJournal of Nutrition
Dietary fish oil increases tumor necrosis factor secretion but decreases interleukin-10 secretion by murine peritoneal macrophages.The Journal of nutrition
[Effect of dietary fish-oil on survival of experimental animals after infection with Streptococcus pneumoniae or Klebsiella pneumoniae.].Laeknabladid
[Beneficial effect of dietary fish-oil is independent of the infection site.].Laeknabladid

2001

[The effect of dietary fish oil on bacterial growth in vivo.].Laeknabladid

1998

Beneficial effects of cytokine induced hyperlipidemia.Zeitschrift fur Ernahrungswissenschaft
Eneficial effects of cytokine induced hyperlipidemiaZeitschrift fur Ernahrungswissenschaft

1997

Dietary Fish Oil Supplementation Increases Survival in Mice Following Klebsiella pneumoniae InfectionScandinavian Journal of Infectious Diseases
LPS and cytokines regulate extra hepatic mRNA levels of apolipoproteins during the acute phase response in Syrian hamsters.Biochimica et biophysica acta
LPS and cytokines regulate extra hepatic mRNA levels of apolipoproteins during the acute phase response in Syrian hamstersBiochimica et Biophysica Acta - Lipids and Lipid Metabolism
[Dietary fish-oil supplementation increases survival in mice following Klebsiella pneumoniae infection.].Laeknabladid
LPS and cytokines regulate extra hepatic mRNA levels of apolipoproteins during the acute phase response in Syrian hamstersBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

1996

Endotoxin and cytokines decrease serum levels and extra hepatic protein and mRNA levels of cholesteryl ester transfer protein in Syrian hamstersJournal of Clinical Investigation
Endotoxin and cytokines decrease serum levels and extra hepatic protein and mRNA levels of cholesteryl ester transfer protein in syrian hamsters.The Journal of clinical investigation

1995

Effects of endotoxin on lipid metabolism.Biochemical Society transactions
Dietary n - 3 polyunsaturated fatty acids modify Syrian hamster platelet and macrophage phospholipid fatty acyl composition and eicosanoid synthesis: a controlled studyBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism

1994

Effects of TNF, IL-1, and the combination of both cytokines on cholesterol metabolism in Syrian hamstersLymphokine and Cytokine Research
Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters.The Journal of clinical investigation
Effects of TNF, IL-1, and the combination of both cytokines on cholesterol metabolism in Syrian hamsters.Lymphokine and cytokine research
Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamstersJournal of Clinical Investigation
Effects of endotoxin and cytokines on lipid metabolismCurrent Opinion in Lipidology
Effects of endotoxin and cytokines on lipid metabolism.Current opinion in lipidology

1993

Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters.The Journal of nutrition
The effects of dietary n-3 polyunsaturated fatty acids and cyclic AMP-elevating agents on tumor necrosis factor production by murine-resident and thioglycollate-elicited peritoneal macrophagesThe Journal of Nutritional Biochemistry
Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamstersJournal of Nutrition
Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamstersJournal of Lipid Research
The effects of dietary n-3 polyunsaturated fatty acids and cyclic AMP-elevating agents on tumor necrosis factor production by murine-resident and thioglycollate-elicited peritoneal macrophagesThe Journal of Nutritional Biochemistry
Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters.Journal of lipid research

1992

Kinetics of tumour necrosis factor and prostaglandin production by murine resident peritoneal macrophages as affected by ditary n-3 polyunsaturated fatty acidsImmunology
Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanismBiochemical and Biophysical Research Communications
Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism.Biochemical and biophysical research communications
Increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio increases tumor necrosis factor production by murine resident peritoneal macrophages without an effect on elicited peritoneal macrophages.The Journal of nutrition
Increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio increases tumor necrosis factor production by murine resident peritoneal macrophages without an effect on elicited peritoneal macrophagesJournal of Nutrition

1991

Tumor necrosis factor production by murine resident peritoneal macrophages is enhanced by dietary n−3 polyunsaturated fatty acidsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research
Effect of increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio on murine liver and peritoneal cell fatty acids and eicosanoid formationJournal of Nutrition
Effect of increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio on murine liver and peritoneal cell fatty acids and eicosanoid formation.The Journal of nutrition
Tumor necrosis factor production by murine resident peritoneal macrophages is enhanced by dietary n-3 polyunsaturated fatty acidsBBA - Molecular Cell Research

1988

Extraction of Lipid and Cholesterol from Fish Muscle with Supercritical FluidsJournal of Food Science

Keywords for Specialisation:

Nutritional immunology, omega-3 fatty acids, inflammation