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Guðmundur H Guðmundsson - Professor
–
School of Engineering and Natural Sciences
Guðmundur H Guðmundsson
Íslenska
Professor
Professor
Location
Læknagarður / Lg-550
Phone
525 - 5276
Email
ghrafn [at] hi.is
Unit
Faculty of Life and Environmental Sciences
Website
http://www.hi.is/~ghrafn
Published Work
Guðmundur H Guðmundsson - published work
Curriculum Vitae
Guðmundur H Guðmundsson - Curriculum Vitae
ORCID site
https://orcid.org/0000-0001-5793-0565
Research portal – Guðmundur H Guðmundsson
Courses 2024 - 2025
LÍF614M - Cell Biology II
LÍF223F - Research in molecular biology and biochemistry
LÍF315G - Cell Biology
Education
1992
,
Ph.D.
,
University of Stockholm
,
Microbiology
Published works
2024
Bile acid metabolites enhance expression of cathelicidin antimicrobial peptide in airway epithelium through activation of the TGR5-ERK1/2 pathway.
Scientific reports
2023
Butyrate-induced IL-22 expression in fish macrophages contributes to bacterial clearance.
Fish & shellfish immunology
Vitamin D influences gut microbiota and acetate production in zebrafish (
Danio rerio
) to promote intestinal immunity against invading pathogens.
Gut microbes
2022
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial Cells
Journal of Innate Immunity
2020
Azithromycin has lung barrier protective effects in a cell model mimicking ventilator-induced lung injury.
ALTEX
Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation.
Antibiotics (Basel, Switzerland)
2019
Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity.
Scientific reports
2018
A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial.
Materials science & engineering. C, Materials for biological applications
Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D
3
as host directed therapy.
BMC infectious diseases
Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice.
Frontiers in immunology
Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.
Infection and immunity
2017
Inducers of salmon innate immunity: An in vitro and in vivo approach.
Fish & shellfish immunology
Assays for Identifying Inducers of the Antimicrobial Peptide LL-37.
Methods in molecular biology (Clifton, N.J.)
2016
Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.
Scientific reports
Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors.
Scientific reports
2015
Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture.
Laboratory investigation; a journal of technical methods and pathology
Cathelicidins positively regulate pancreatic β-cell functions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial.
PloS one
Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line.
Immunobiology
Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways.
Molecular immunology
Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.
Autophagy
2014
Ciprofloxacin Affects Host Cells by Suppressing Expression of the Endogenous Antimicrobial Peptides Cathelicidins and Beta-Defensin-3 in Colon Epithelia.
Antibiotics (Basel, Switzerland)
A review of the innate immune defence of the human foetus and newborn, with the emphasis on antimicrobial peptides.
Acta paediatrica (Oslo, Norway : 1992)
Conditions associated with the cystic fibrosis defect promote chronic Pseudomonas aeruginosa infection.
American journal of respiratory and critical care medicine
2013
Treatment with phenylbutyrate in a pre-clinical trial reduces diarrhea due to enteropathogenic Escherichia coli: link to cathelicidin induction.
Microbes and infection
Differential regulation of cathelicidin in salmon and cod.
Fish & shellfish immunology
Oral intake of phenylbutyrate with or without vitamin D3 upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis.
BMC pulmonary medicine
Lactose in human breast milk an inducer of innate immunity with implications for a role in intestinal homeostasis.
PloS one
2012
Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial.
BMC infectious diseases
2011
The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells.
Clinical immunology (Orlando, Fla.)
Functional characterization of codCath, the mature cathelicidin antimicrobial peptide from Atlantic cod (Gadus morhua).
Peptides
Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.
PloS one
2010
Cod cathelicidin: isolation of the mature peptide, cleavage site characterisation and developmental expression.
Developmental and comparative immunology
Battle and balance at mucosal surfaces--the story of Shigella and antimicrobial peptides.
Biochemical and biophysical research communications
2009
Phenylbutyrate induces antimicrobial peptide expression.
Antimicrobial agents and chemotherapy
2008
PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells.
Molecular immunology
[Natural immunity--first line defense. New treatment against infections and autoimmune diseases in sight].
Lakartidningen
Characterisation of cathelicidin gene family members in divergent fish species.
Molecular immunology
2007
Antimicrobial components of the neonatal gut affected upon colonization.
Pediatric research
Differentiation potential of a basal epithelial cell line established from human bronchial explant.
In vitro cellular & developmental biology. Animal
2006
Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection.
Infection and immunity
Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype.
Scandinavian journal of immunology
Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic.
Proceedings of the National Academy of Sciences of the United States of America
Involvement of the antimicrobial peptide LL-37 in human atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology
Malassezia sympodialis differently affects the expression of LL-37 in dendritic cells from atopic eczema patients and healthy individuals.
Allergy
Host antimicrobial defence peptides in human disease.
Current topics in microbiology and immunology
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection.
Nature medicine
2005
The antimicrobial peptide rCRAMP is present in the central nervous system of the rat.
Journal of neurochemistry
Expression and activity of beta-defensins and LL-37 in the developing human lung.
Journal of immunology (Baltimore, Md. : 1950)
Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions.
Cellular and molecular life sciences : CMLS
Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod (Gadus morhua).
The FEBS journal
Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37.
Cellular microbiology
2004
First line of defense in early human life.
Seminars in perinatology
2003
Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense.
Pediatric research
Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluid: guanidine, N-[3-[(aminoiminomethyl)amino]propyl]-N-dodecyl-, a potential source of error in the analysis of antibacterial agents.
Rapid communications in mass spectrometry : RCM
Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways.
Gut
Antimicrobial peptides in the first line defence of human colon mucosa.
Peptides
Hsp90 binds CpG oligonucleotides directly: implications for hsp90 as a missing link in CpG signaling and recognition.
Cellular and molecular life sciences : CMLS
2002
Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis.
Human genetics
The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa.
The British journal of dermatology
2001
Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator.
Nature medicine
Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus.
The Journal of investigative dermatology
2000
Decreased pulmonary levels of the anti-inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmatics.
Cellular and molecular life sciences : CMLS
The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations.
Blood
1999
Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system.
Journal of immunological methods
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.
The Biochemical journal
Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients.
American journal of respiratory and critical care medicine
1998
Cloning and characterization of ZNF189, a novel human Krüppel-like zinc finger gene localized to chromosome 9q22-q31.
Genomics
Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37.
The Journal of biological chemistry
1997
The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders.
The Journal of biological chemistry
1996
The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.
European journal of biochemistry
NK-lysin, structure and function of a novel effector molecule of porcine T and NK cells.
Veterinary immunology and immunopathology
PR-39, a proline-rich peptide antibiotic from pig, and FALL-39, a tentative human counterpart.
Veterinary immunology and immunopathology
1995
Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39.
Proceedings of the National Academy of Sciences of the United States of America
FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.
Proceedings of the National Academy of Sciences of the United States of America
1992
Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes.
The Journal of biological chemistry
1991
Cell-free immunity in Cecropia. A model system for antibacterial proteins.
European journal of biochemistry
A highly repetitive, mariner-like element in the genome of Hyalophora cecropia.
The Journal of biological chemistry
The cecropin locus. Cloning and expression of a gene cluster encoding three antibacterial peptides in Hyalophora cecropia.
The Journal of biological chemistry
1990
A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomes.
The Journal of biological chemistry
1987
Insect immunity--a gene system for antibacterial proteins.
Memorias do Instituto Oswaldo Cruz
Keywords for Specialisation:
Innate immunity
Antimicrobial peptides
Epithelial biology
Intracellular signal pathways
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