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Forsíða

Forsíða

Guðmundur H Guðmundsson - Professor

Guðmundur H Guðmundsson

–

School of Engineering and Natural Sciences

Guðmundur H Guðmundsson

Professor

Professor

Location
Læknagarður / Lg-550
Phone
525 - 5276
Email
ghrafn [at] hi.is

Unit
Faculty of Life and Environmental Sciences
Website
http://www.hi.is/~ghrafn
Published Work
Guðmundur H Guðmundsson - published work

Curriculum Vitae
Guðmundur H Guðmundsson - Curriculum Vitae
ORCID site
https://orcid.org/0000-0001-5793-0565
Research portal – Guðmundur H Guðmundsson

Published works

2024

Bile acid metabolites enhance expression of cathelicidin antimicrobial peptide in airway epithelium through activation of the TGR5-ERK1/2 pathwayScientific Reports

2023

Butyrate-induced IL-22 expression in fish macrophages contributes to bacterial clearanceFish and Shellfish Immunology
Modulation of innate immunity in airway epithelium for host-directed therapyFrontiers in Immunology
Aroylated phenylenediamine HO53 modulates innate immunity, histone acetylation and metabolismMolecular Immunology
Butyrate induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages from turbot (Scophthalmus maximus L.)Fish & shellfish immunology
Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogensGut Microbes

2022

Vitamin D Enhances Neutrophil Generation and Function in Zebrafish (Danio rerio)Journal of Innate Immunity
The Novel Inducer of Innate Immunity HO53 Stimulates Autophagy in Human Airway Epithelial CellsJournal of Innate Immunity

2020

Host Directed Therapy Against Infection by Boosting Innate ImmunityFrontiers in Immunology
Azithromycin has lung barrier protective effects in a cell model mimicking ventilator-induced lung injuryAltex
Innate effector systems in primary human macrophages sensitize multidrug-resistant klebsiella pneumoniae to antibioticsInfection and Immunity
Host-directed therapy as a novel treatment strategy to overcome tuberculosisAntibiotics

2019

Azithromycin induces epidermal differentiation and multivesicular bodies in airway epitheliaRespiratory Research
Innovative in vitro method to study ventilator induced lung injuryAltex
Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrityScientific Reports

2018

Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in MiceFrontiers in Immunology
A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trialMaterials Science and Engineering C
Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D3 as host directed therapyBMC Infectious Diseases
Inducers of salmon innate immunityFish and Shellfish Immunology

2017

Treatment with entinostat heals experimental cholera by affecting physical and chemical barrier functions of intestinal epitheliaAntimicrobial Agents and Chemotherapy
Assays for identifying inducers of the antimicrobial peptide LL-37
Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial LayersInfection and Immunity

2016

Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factorsScientific Reports
Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell lineImmunobiology
Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of InfectionsScientific Reports
Cathelicidins positively regulate pancreatic β-cell functionsFASEB Journal

2015

Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cellsPeerJ
Significant effects of oral phenylbutyrate and Vitamin D₃ adjunctive therapy in pulmonary tuberculosisPLoS ONE
Phenylbutyrate induces cathelicidin expression via the vitamin D receptorMolecular Immunology
Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cellsPeerJ
Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of mycobacterium tuberculosis in human macrophagesAutophagy

2014

Boosting innate immunityInnate Immunity
Ciprofloxacin affects host cells by suppressing expression of the endogenous antimicrobial peptides cathelicidins and beta-defensin-3 in colon EpitheliaAntibiotics
A review of the innate immune defence of the human foetus and newborn, with the emphasis on antimicrobial peptidesActa Paediatrica, International Journal of Paediatrics
Label-free quantitative mass spectrometry reveals novel pathways involved in LL-37 expressionJournal of Innate Immunity
Pradeep Conditions associated with the cystic fibrosis defect promote chronic Pseudomonas aeruginosa infectionAmerican Journal of Respiratory and Critical Care Medicine

2013

Differential regulation of cathelicidin in salmon and codFish and Shellfish Immunology
Lactose in Human Breast Milk an Inducer of Innate Immunity with Implications for a Role in Intestinal HomeostasisPLoS ONE
Helping the host
Treatment with phenylbutyrate in a pre-clinical trial reduces diarrhea due to enteropathogenic Escherichia coliMicrobes and Infection
Oral intake of phenylbutyrate with or without vitamin D₃ upregulates the cathelicidin LL-37 in human macrophagesBMC Pulmonary Medicine

2012

The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cellsClinical Immunology
Efficacy of sodium butyrate adjunct therapy in shigellosisBMC Infectious Diseases

2011

Antimicrobial peptides important in innate immunityFEBS Journal
Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epitheliaPLoS ONE
Cod cathelicidinDevelopmental and Comparative Immunology
Functional characterization of codCath, the mature cathelicidin antimicrobial peptide from Atlantic cod (Gadus morhua)Peptides

2010

Azithromycin maintains airway epithelial integrity during Pseudomonas aeruginosa infectionAmerican Journal of Respiratory Cell and Molecular Biology
Battle and balance at mucosal surfaces - The story of Shigella and antimicrobial peptidesBiochemical and Biophysical Research Communications

2009

Phenylbutyrate induces antimicrobial peptide expressionAntimicrobial Agents and Chemotherapy

2008

PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cellsMolecular Immunology
Characterisation of cathelicidin gene family members in divergent fish speciesMolecular Immunology
Bacterial DNA indicated as an important inducer of fish cathelicidinsMolecular Immunology
Naturlig immunitet - Första linjens försvarLakartidningen

2007

Antimicrobial Components of the Neonatal Gut Affected Upon ColonizationPediatric Research
Differentiation potential of a basal epithelial cell line established from human bronchial explantIn Vitro Cellular and Developmental Biology - Animal

2006

Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibioticProceedings of the National Academy of Sciences of the United States of America
Novel effects of azithromycin on tight junction proteins in human airway epitheliaAntimicrobial Agents and Chemotherapy
Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infectionInfection and Immunity
The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infectionNature Medicine
Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotypeScandinavian Journal of Immunology
Malassezia sympodialis differently affects the expression of LL-37 in dendritic cells from atopic eczema patients and healthy individualsAllergy: European Journal of Allergy and Clinical Immunology
Involvement of the antimicrobial peptide LL-37 in human atherosclerosisArteriosclerosis, Thrombosis, and Vascular Biology
Host antimicrobial defence peptides in human disease

2005

Neisseria gonorrhoeae downregulates expression of the human antimicrobial peptide LL-37Cellular Microbiology
Antimicrobial peptides in human blood
Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactionsCellular and Molecular Life Sciences
Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod (Gadus morhua)FEBS Journal
Human meconium contains antimicrobial peptides/proteinsPediatric Research
The antimicrobial peptide rCRAMP is present in the central nervous system of the ratJournal of Neurochemistry
Expression and activity of β-defensins and LL-37 in the developing human lungJournal of Immunology

2004

30 antimicrobial components of vernix caseosaPediatric Research
First line of defense in early human lifeSeminars in Perinatology
51 the human cathelicidinPediatric Research

2003

Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytesGut
Antimicrobial peptides in the first line defence of human colon mucosaPeptides
Antimicrobial polypeptides of human vernix caseosa and amniotic fluidPediatric Research
Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosisHuman Genetics
Bed topography and stickiness inferred from surface measurements on fast flowing ice streamsJournal of Glaciology
Identification of a potent antibacterial factor isolated from bronchoalveolar lavage fluidRapid Communications in Mass Spectrometry
Hsp90 binds CpG oligonucleotides directlyCellular and Molecular Life Sciences
Phylogeny, processing and expression of the rat cathelicidin rCRAMPCellular and Molecular Life Sciences

2002

The newborn infant is protected by an innate antimicrobial barrierBritish Journal of Dermatology

2001

Downregulation of bactericidal peptides in enteric infectionsNature Medicine
Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A streptococcusJournal of Investigative Dermatology

2000

The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populationsBlood
Decreased pulmonary levels of the anti-inflammatory Clara cell 16 kDa protein after induction of airway inflammation in asthmaticsCellular and Molecular Life Sciences
The response of a glacier to a surface disturbance: a case study on Vatnajökull ice cap, IcelandAnnals of Glaciology

1999

Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune systemJournal of Immunological Methods
Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patientsAmerican Journal of Respiratory and Critical Care Medicine
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranesBiochemical Journal

1998

Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37Journal of Biological Chemistry
Cloning and characterization of ZNF189, a novel human Kruppel-like zinc finger gene localized to chromosome 9q22-q31Genomics

1997

The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disordersJournal of Biological Chemistry

1996

The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytesEuropean Journal of Biochemistry
PR-39, a proline-rich peptide antibiotic from pig, and FALL-39, a tentative human counterpartVeterinary Immunology and Immunopathology
NK-lysin, structure and function of a novel effector molecule of porcine T and NK cellsVeterinary Immunology and Immunopathology

1995

FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testisProceedings of the National Academy of Sciences of the United States of America
Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family memberProceedings of the National Academy of Sciences of the United States of America
NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activityEMBO Journal

1992

Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomesJournal of Biological Chemistry

1991

The cecropin locusJournal of Biological Chemistry
Cell‐free immunity in CecropiaEuropean Journal of Biochemistry
A highly repetitive, mariner-like element in the genome of Hyalophora cecropiaJournal of Biological Chemistry

1990

A large presecretory protein translocates both cotranslationally, using signal recognition particle and ribosome, and post-translationally, without these ribonucleoparticles, when synthesized in the presence of mammalian microsomesJournal of Biological Chemistry

1987

Insect immunityFEBS Letters
Insect immunity--a gene system for antibacterial proteins.Memórias do Instituto Oswaldo Cruz

Keywords for Specialisation:

Innate immunity

Antimicrobial peptides

Epithelial biology

Intracellular signal pathways