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Francois Olivier Mohan Singh - Assistant Professor

Francois Olivier Mohan Singh

–

Heilbrigðisvísindasvið

Francois Olivier Mohan Singh

Assistant Professor

Location
Læknagarður / Lg-503
Email
francois [at] hi.is

Unit
Department of Physiology

ORCID site
https://orcid.org/0000-0002-1696-9815

Published works

2024

Proteomic and functional comparison between human induced and embryonic stem cells
PINK1 regulated mitophagy is evident in skeletal musclesAutophagy Reports
Proteomic and functional comparison between human induced and embryonic stem cells

2023

PINK1 regulated basal mitophagy is evident in skeletal muscles

2022

Physiological functions of mitophagyCurrent Opinion in Physiology
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood–Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2Journal of the American Chemical Society
Physiological functions of mitophagyCurrent Opinion in Physiology

2021

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in miceeLife
IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes.Nature communications
Impact of Type II LRRK2 inhibitors on signaling and mitophagy.The Biochemical journal
Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in miceeLife
Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1Science Advances
Parkinson's disease and mitophagy: an emerging role for LRRK2.Biochemical Society transactions
Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α OverexpressionInternational Journal of Molecular Sciences

2020

Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle ExpressionBiomedicines
Mechanisms of statin-associated skeletal muscle-associated symptomsPharmacological Research
Role of PGC-1-alpha-associated Mitochondrial Biogenesis in Statin-induced Myotoxicity.European cardiology
Semi-automated quantitation of macroautophagy with the auto-QC counter v1

2019

PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice.Acta physiologica (Oxford, England)
Semi-automated quantitation of mitophagy in cells and tissues.Mechanisms of ageing and development

2018

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.Open biology
PGC-1β modulates statin-associated myotoxicity in mice. Archives of toxicology
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.Cell metabolism

2017

Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia.Frontiers in physiology
IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis.Acta neuropathologica
Comparative analysis of resuscitation using human serum albumin and crystalloids or 130/0.4 hydroxyethyl starch and crystalloids on skeletal muscle metabolic profile during experimental haemorrhagic shock in swine: A randomised experimental study.European journal of anaesthesiology

2016

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency.Frontiers in physiology
Cardiac mitochondrial oxidative capacity is partly preserved after cryopreservation with dimethyl sulfoxide.Cryo letters
Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncoupling.Hypertension research : official journal of the Japanese Society of Hypertension
Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle.Antioxidants & redox signaling

2015

Tetrahydrocannabinol induces brain mitochondrial respiratory chain dysfunction and increases oxidative stress: a potential mechanism involved in cannabis-related stroke.BioMed research international
Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency.American journal of physiology. Endocrinology and metabolism
Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis.Biochimica et biophysica acta
Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusion.American Journal of Physiology - Heart and Circulatory Physiology
A new murine model of sustainable and durable chronic critical limb ischemia fairly mimicking human pathology.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
High reactive oxygen species in fibrotic and nonfibrotic skin of patients with diffuse cutaneous systemic sclerosis.Free radical biology & medicine

2014

Mitochondria: mitochondrial participation in ischemia-reperfusion injury in skeletal muscle.The international journal of biochemistry & cell biology
Cryopreservation with dimethyl sulfoxide prevents accurate analysis of skinned skeletal muscle fibers mitochondrial respiration.Biochimie
Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations.Journal of applied physiology (Bethesda, Md. : 1985)

2013

Avian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageing.Frontiers in zoology

Keywords for Specialisation:

Mitochondrial biogenesis

Skeletal muscle

Parkinson's disease

Reactive oxygen species