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Engilbert Sigurðsson - Professor
–
Heilbrigðisvísindasvið
Engilbert Sigurðsson
Íslenska
Professor
Professor of Psychiatry & Consultant Psychiatrist Landspitali - The National University Hospital
Location
LSH - Hringbraut
Phone
8245345
Email
es [at] hi.is
Unit
Faculty of Medicine
ORCID site
https://orcid.org/0000-0001-9404-7982
Research portal – Engilbert Sigurðsson
Courses 2024 - 2025
LÆK404F - Psychiatry
LÆK304F - Psychiatry
Education
1991
,
Kandídatspróf
,
University of Iceland
,
Medicine
Professional Experience
-
,
Professor/consultan psychiatrist,
Faculty of Medicine
Published works
2023
Methylphenidate-induced psychosis in a young adult with newly diagnosed ADHD: A case report,Geðrof í kjölfar ADHD-lyfjameðferðar: Sjúkratilfelli
Laeknabladid
Psychedelics and treatment of mental disorders: A survey of attitudes and knowledge among psychiatrists, general practitioners and psychologists in Iceland
Læknablaðið
Genetic structure of major depression symptoms across clinical and community cohorts
medRxiv
Polygenic risk prediction: why and when out-of-sample prediction R
2
can exceed SNP-based heritability
American Journal of Human Genetics
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
iScience
2022
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Nature
Symptoms, physical measures and cognitive tests after SARS-CoV-2 infection in a large population-based case-control study
ResearchSquare
Symptoms, physical measures and cognitive tests after SARS-CoV-2 infection in a large population-based case-control study
Research Square
Identifying the Common Genetic Basis of Antidepressant Response
Biological Psychiatry Global Open Science
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Biological Psychiatry
Thirty novel sequence variants impacting human intracranial volume
Brain Communications
2021
Case Report: Successful Implementation of Integrative Cognitive Remediation for Early Psychosis
Frontiers in Psychiatry
Evaluation of mechanism of change in transdiagnostic cognitive behaviour therapy using single case experimental design
Journal of Behavior Therapy and Experimental Psychiatry
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Biological psychiatry
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Nature genetics
HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.
Translational psychiatry
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
Molecular Psychiatry
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank (Molecular Psychiatry, (2020), 25, 7, (1430-1446), 10.1038/s41380-019-0546-6)
Molecular Psychiatry
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Molecular Psychiatry
Trail making test, stroop, and verbal fluency: Regression-based norms for the Icelandic population
Archives of Clinical Neuropsychology
Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophrenia
Intelligence
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts
Biological Psychiatry
2020
Integrative cognitive remediation for early psychosis: A 12-month follow-up
Psychiatry Research
Schizophrenia, cognition, and aging: cognitive deficits and the relationship between test performance and aging
Aging, Neuropsychology, and Cognition
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
medRxiv
‘You should always look at the washing machine without actually being in it!’ Thematic framework analysis of patients’ understanding of transdiagnostic cognitive behaviour therapy and its mechanisms
Psychology and Psychotherapy: Theory, Research and Practice
Use of serotonin reuptake inhibitors is not associated with increased bleeding after CABG
General Thoracic and Cardiovascular Surgery
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Nature Genetics
Innovations and challenges in medical education in times of burgeoning software evolution,Nýjungar og áskoranir í læknanámi á tímum rafrænna stökkbreytinga
Laeknabladid
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Nature Communications
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Molecular Psychiatry
Complement genes contribute sex-biased vulnerability in diverse disorders
Nature
Árangur ADHD-lyfjameðferðar fullorðinna í ADHD-teymi Landspítala 2015-2017
Læknablaðið
Should Patients' Values Be Discussed in Relation to Long-Term Blood Monitoring Before and During Clozapine Treatment?
Journal of clinical psychopharmacology
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression
Biological Psychiatry
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
Biological Psychiatry
2019
A polygenic resilience score moderates the genetic risk for schizophrenia.
Molecular psychiatry
Integrative cognitive remediation for early psychosis: Results from a randomized controlled trial
Psychiatry Research
Sequence variants with large effects on cardiac electrophysiology and disease
Nature Communications
High altitude illness and related diseases - a review
Laeknabladid
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Nature Genetics
Trail Making Test, Stroop, and Verbal Fluency: Regression-Based Norms for the Icelandic Population
Archives of Clinical Neuropsychology
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)
Nature Genetics
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Nature Communications
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2)
Nature Genetics
Identification of common genetic risk variants for autism spectrum disorder
Nature Genetics
Cognitive measures and performance on the antisaccade eye movement task
Journal of Cognition
Genome-wide association study identifies 30 loci associated with bipolar disorder
Nature Genetics
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Social and non‐social measures of cognition for predicting self‐reported and informant‐reported functional outcomes in early psychosis
Scandinavian Journal of Psychology
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Cell
Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study
JAMA Psychiatry
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
Translational Psychiatry
2018
A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework
BMC Genomics
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
Communications Biology
Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
Biological Psychiatry
Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder
PLoS ONE
Improving genetic prediction by leveraging genetic correlations among human diseases and traits
Nature Communications
Constipation, ileus and medication use during clozapine treatment in patients with schizophrenia in Iceland
Nordic Journal of Psychiatry
Age at first birth in women is genetically associated with increased risk of schizophrenia
Scientific Reports
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Cell
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Nature Genetics
Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction
Addiction biology
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
The American Journal of Human Genetics
A Randomized, Controlled Trial on Integrated Cognitive Remediation for Early Psychosis: Effectiveness and Factors Associated with Treatment Response
EARLY INTERVENTION IN PSYCHIATRY
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Nature Genetics
2017
Risk of diabetes and dyslipidemia during clozapine and other antipsychotic drug treatment of schizophrenia in Iceland
Nordic Journal of Psychiatry
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Biological Psychiatry
15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia
Translational Psychiatry
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
Nature Communications
Methylphenidate disintegration from oral formulations for intravenous use by experienced substance users
Drug and Alcohol Dependence
Truncating mutations in RBM12 are associated with psychosis
Nature Genetics
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes
Scientific Reports
Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis
Biological Psychiatry
Reproductive fitness and genetic risk of psychiatric disorders in the general population
Nature Communications
Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulations
JAMA Psychiatry
2016
Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in Iceland
BMC Psychiatry
Clozapine treatment and discontinuation in Iceland: A national longitudinal study using electronic patient records
Nordic Journal of Psychiatry
Intravenous Use of Prescription Psychostimulants; A Comparison of the Pattern and Subjective Experience between Different Methylphenidate Preparations, Amphetamine and Cocaine
European Addiction Research
A new chapter [Editorial]
Laeknabladid
Multimorbidity and use of hypnotic and anxiolytic drugs: Cross-sectional and follow-up study in primary healthcare in Iceland
BMC Family Practice
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
PLoS Genetics
Kaflaskil
Læknablaðið
2015
The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjects
Molecular Psychiatry
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
Nature Genetics
Að höggva undan sér fæturna
Læknablaðið
Prevalent intravenous abuse of methylphenidate among treatment-seeking patients with substance abuse disorders: A descriptive population-based study
Journal of Addiction Medicine
[Destabilising the foundations of health and safety [Editorial]].
Prevalent Intravenous Abuse of Methylphenidate Among Treatment-Seeking Patients With Substance Abuse Disorders
Journal of Addiction Medicine
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
American Journal of Human Genetics
Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
Nature Neuroscience
Transdiagnostic cognitive behavioural treatment and the impact of co-morbidity: An open trial in a cohort of primary care patients
Nordic Journal of Psychiatry
2014
Emetophobia: Morbid fear of vomiting and nausea,Emetophobia: Sjúklegur ótti vio uppköst og ógleoi
Laeknabladid
Common variant at 16p11.2 conferring risk of psychosis
Molecular Psychiatry
Variability inworking memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway
JAMA Psychiatry
Biological insights from 108 schizophrenia-associated genetic loci
Nature
Identification of pathways for bipolar disorder: A meta-analysis
JAMA Psychiatry
Does the use of cannabis increase the risk for psychosis and the development of schizophrenia?,Eykur notkun kannabis hættu á gedrofi og próun gedklofa?
Laeknabladid
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene
Molecular Psychiatry
CNVs conferring risk of autism or schizophrenia affect cognition in controls
Nature
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
American Journal of Human Genetics
2013
Risk of disasters in Landspitala
Laeknabladid
Schizophrenia genetic variants are not associated with intelligence
Psychological Medicine
Evaluation of the Psychometric Properties of the Icelandic Version of the Clinical Outcomes in Routine Evaluation-Outcome Measure, its Transdiagnostic Utility and Cross-Cultural Validation
Clinical Psychology & Psychotherapy
Opening Pandora's box in the UK: A hypothetical pharmacogenetic test for clozapine
Pharmacogenomics
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Nature Genetics
The effect of antidepressants and sedatives on the efficacy of transdiagnostic cognitive behavioral therapy in groups in primary care,Áhrif punglyndislyfja og róandi lyfja á árangur af ósértÆkri hugrÆnni atferlismeofero hópa í heilsugÆslu
Laeknabladid
A mega-Analysis of genome-wide association studies for major depressive disorder
Molecular Psychiatry
All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs
Plos Genetics
Opening Pandora’s box in the UK: a hypothetical pharmacogenetic test for clozapine
Pharmacogenomics
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Lancet
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
Biological Psychiatry
[Risk of a crisis developing at Landspítali].,Hserra á neydarástandi á landspítala.
Læknabladid
2012
Response to Boot et al. Letter
American Journal of Psychiatry
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe
Molecular Psychiatry
Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia
Biological Psychiatry
Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder
Biological Psychiatry
2011
[Human nature and the development of scientific journals].
Laknabladid
At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia
Biological Psychiatry
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 Is associated with disease risk and cortical surface area
Biological Psychiatry
Developments in schizophrenia genetics: From linkage to microchips, deletions and duplications
Nordic Journal of Psychiatry
Genome-wide association study identifies five new schizophrenia loci
Nature Genetics
Copy number variations of chromosome 16p13.1 region associated with schizophrenia
Molecular Psychiatry
Common variants on 8p12 and 1q24.2 confer risk of schizophrenia
Nature Genetics
Early detection of prostate cancer: Is screening in general practice justifiable?
Scandinavian Journal of Primary Health Care
[The Journal's progress and threats to the welfare of patients [Editorial]].
Laknabladid
Expanding the range of ZNF804A variants conferring risk of psychosis
Molecular Psychiatry
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Nature Genetics
Back to the past. Case report and review on retrograde memory loss
Laeknabladid
Efficacy of cognitive behavioral therapy in the treatment of mood and anxiety disorders in adults
Laeknabladid
Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness
American Journal of Psychiatry
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
Human Molecular Genetics
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus
Nature
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder (The American Journal of Human Genetics (2011) 88, (372-381))
American Journal of Human Genetics
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
American Journal of Human Genetics
2010
Catechol-o-methyltransferase val
158
met polymorphism and antisaccade eye movements in schizophrenia
Schizophrenia Bulletin
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort
Journal of Psychiatric Research
S100B Profiles and Cognitive Function at High Altitude
High Altitude Medicine & Biology
Hlutverk lækna í hagrædingu innan heilbrigdiskerfisins: Gagnsæi, ord og efndir
Laeknabladid
2009
Scientific articles in the Icelandic Medical Journal 2004-2008: An overview,Hverjir skrifa í Læknablaoio?: Yfirlit yfir fræ Oigreinar sí oustu fimm ára
Laeknabladid
[Public views on antidepressant treatment: lessons from a national survey].
Laknabladid
COMT val158met genotype and smooth pursuit eye movements in schizophrenia
Psychiatry Research
FÍFLagangur ad vori
Laeknabladid
Loss, appreciation and regret,Enginn veit hvad átt hefur fyrr en misst hefur
Laeknabladid
Neuregulin-1 genotypes and eye movements in schizophrenia
European Archives of Psychiatry and Clinical Neuroscience
[Scientific articles in the Icelandic Medical Journal 2004-2008: an overview].
Laknabladid
Disruption of the neurexin 1 gene is associated with schizophrenia
Human Molecular Genetics
[Loss, appreciation and regret].
Laknabladid
Common variants conferring risk of schizophrenia
Nature
2008
Vacuum-Assisted Closure for Successful Treatment of a Major Contaminated Gunshot Chest-Wound: A Case Report
European Journal of Trauma and Emergency Surgery
Eye movement deficits in schizophrenia
European Archives of Psychiatry and Clinical Neuroscience
Large recurrent microdeletions associated with schizophrenia
Nature
Public views on antidepressant treatment: Lessons from a national survey
Nordic Journal of Psychiatry
[Odds, fate and fortunes].
Laknabladid
2007
Neuregulin-1 risk haplotype and eye movements in schizophrenia
European Neuropsychopharmacology
Support for involvement of the AHI1 locus in schizophrenia
European Journal of Human Genetics
Oculomotor deficits in schizophrenia: Validation of endophenotypes in a genetically homogenous Icelandic sample
European Psychiatry
Cathechol-o-methyltransferase polymorphism and eye movements in schizophrenia
European Neuropsychopharmacology
Cognitive function in schizophrenia and effects of neuregulin 1
Schizophrenia Bulletin
2006
Health-related quality of life of patients with implantable cardioverter defibrillators compared with that of pacemaker recipients
EP Europace
Neuregulin-1 risk genotype and eye movements in schizophrenia
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Neuregulin-1 and eye movements in schizophrenia
Schizophrenia Research
Neuregulin 1 and cognitive function in schizophrenia
Schizophrenia Research
Gene in common to schizophrenia and bipolar disorder mapped to 17q21.31-q22
American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
2005
Views on antidepressants among adults in Iceland: a population-based survey
European Neuropsychopharmacology
2004
Genetic loading in schizophrenia in relation to the at-risk haplotype of the NRG1 gene
Nordic Journal of Psychiatry
The deficit syndrome of schizophrenia and neuregulin1
Schizophrenia Research
Genomics and genealogy provide an Icelandic springboard into the human gene pool
Journal of Mental Health
2003
Neuregulin 1 detected as a susceptibility gene in schizophrenia
Nordic Journal of Psychiatry
Schizophrenia genes identified by positional cloning affect the glutamatergic system
European Neuropsychopharmacology
2002
Are Impaired Childhood Motor Skills a Risk Factor for Adolescent Anxiety? Results From the 1958 U.K. Birth Cohort and the National Child Development Study
American Journal of Psychiatry
Neuregulin 1 and Susceptibility to Schizophrenia
American Journal of Human Genetics
Childhood motor impairment and persistent anxiety in adolescent boys
European Psychiatry
2001
Family matters: interfaces between child and adult mental health.
Acta Psychiatrica Scandinavica
1999
Neurodevelopmental delay in the severely ill [8] (multiple letters)
British Journal of Psychiatry
Neurodevelopmental delay in the severely ill - Authors' reply
British Journal of Psychiatry
Neurodevelopmental antecedents of early-onset bipolar affective disorder
British Journal of Psychiatry
1994
The effects of electroconvulsive therapy and depression on confabulation, memory processing, and suggestibility
Nordic Journal of Psychiatry
VALUE OF ANTIBODIES TO GAD(65) COMBINED WITH ISLET-CELL CYTOPLASMIC ANTIBODIES FOR PREDICTING IDDM IN A CHILDHOOD POPULATION
Diabetologia
1990
THE 64-KDA BETA-CELL MEMBRANE AUTOANTIGEN AND OTHER TARGET MOLECULES OF HUMORAL AUTOIMMUNITY IN INSULIN-DEPENDENT DIABETES-MELLITUS
Current Topics in Microbiology and Immunology
The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitus
Current Topics in Microbiology and Immunology
1989
PREDICTIVE VALUE OF 64K ANTIBODIES FOR IDDM IN A CHILDHOOD POPULATION
Scandinavian Journal of Immunology
PREDICTIVE VALUE OF MR 64000 ANTIBODIES FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES IN A CHILDHOOD POPULATION
Diabetologia
EXPRESSION OF THE 64K AUTO-ANTIGEN AND A NOVEL TARGET OF DIABETIC AUTOANTIBODIES IN ISLETS OF DIABETES PRONE BB-RATS
Scandinavian Journal of Immunology
Keywords for Specialisation:
Genetics - psychiatry - epidemiology
Genetics - psychiatry - epidemiology - open online courses - personalised medicine
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