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Forsíða

Forsíða

Engilbert Sigurðsson - Professor

Engilbert Sigurðsson

–

School of Health Sciences

Engilbert Sigurðsson

Professor

Professor of Psychiatry & Consultant Psychiatrist Landspitali - The National University Hospital

Location
LSH - Hringbraut
Phone
8245345
Email
es [at] hi.is

Unit
Faculty of Medicine

ORCID site
https://orcid.org/0000-0001-9404-7982

Published works

2021

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.Biological psychiatry
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Nature genetics
HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.Translational psychiatry
Evaluation of mechanism of change in transdiagnostic cognitive behaviour therapy using single case experimental designJournal of Behavior Therapy and Experimental Psychiatry

2020

Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank (Molecular Psychiatry, (2020), 10.1038/s41380-019-0546-6)Molecular Psychiatry
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK BiobankMolecular Psychiatry
Schizophrenia, cognition, and aging: cognitive deficits and the relationship between test performance and agingAging, Neuropsychology, and Cognition
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With DepressionBiological Psychiatry
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 ControlsBiological Psychiatry
‘You should always look at the washing machine without actually being in it!’ Thematic framework analysis of patients’ understanding of transdiagnostic cognitive behaviour therapy and its mechanismsPsychology and Psychotherapy: Theory, Research and Practice
Integrative cognitive remediation for early psychosis: A 12-month follow-upPsychiatry Research
Use of serotonin reuptake inhibitors is not associated with increased bleeding after CABGGeneral Thoracic and Cardiovascular Surgery
Árangur ADHD-lyfjameðferðar fullorðinna í ADHD-teymi Landspítala 2015-2017Læknablaðið
Should Patients' Values Be Discussed in Relation to Long-Term Blood Monitoring Before and During Clozapine Treatment?Journal of clinical psychopharmacology
Complement genes contribute sex-biased vulnerability in diverse disordersNature
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individualsNature Genetics
Innovations and challenges in medical education in times of burgeoning software evolution,Nýjungar og áskoranir í læknanámi á tímum rafrænna stökkbreytingaLaeknabladid
Association of polygenic score for major depression with response to lithium in patients with bipolar disorderMolecular Psychiatry
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK BiobankNature Communications

2019

Gene expression imputation across multiple brain regions provides insights into schizophrenia riskNature Genetics
Identification of common genetic risk variants for autism spectrum disorderNature Genetics
Social and non‐social measures of cognition for predicting self‐reported and informant‐reported functional outcomes in early psychosisScandinavian Journal of Psychology
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)Nature Genetics
Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK BiobankBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Trail Making Test, Stroop, and Verbal Fluency: Regression-Based Norms for the Icelandic PopulationArchives of Clinical Neuropsychology
Genome-wide association study identifies 30 loci associated with bipolar disorderNature Genetics
Sequence variants with large effects on cardiac electrophysiology and diseaseNature Communications
High altitude illness and related diseases - a reviewLaeknabladid
Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization studyJAMA Psychiatry
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disordersMolecular Psychiatry
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric DisordersCell
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorderTranslational Psychiatry
Integrative cognitive remediation for early psychosis: Results from a randomized controlled trialPsychiatry Research
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2)Nature Genetics
A polygenic resilience score moderates the genetic risk for schizophrenia.Molecular psychiatry
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-bornsNature Communications
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophreniaAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

2018

Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics ConsortiumBiological Psychiatry
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 SubphenotypesCell
Polygenic risk scores for schizophrenia and bipolar disorder associate with addictionAddiction biology
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum LikelihoodThe American Journal of Human Genetics
Improving genetic prediction by leveraging genetic correlations among human diseases and traitsNature Communications
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorderCommunications Biology
A Randomized, Controlled Trial on Integrated Cognitive Remediation for Early Psychosis: Effectiveness and Factors Associated with Treatment ResponseEARLY INTERVENTION IN PSYCHIATRY
Age at first birth in women is genetically associated with increased risk of schizophreniaScientific Reports
Constipation, ileus and medication use during clozapine treatment in patients with schizophrenia in IcelandNordic Journal of Psychiatry
Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorderPLoS ONE
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressionNature Genetics
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selectionNature Genetics
A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed frameworkBMC Genomics

2017

Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysisBiological Psychiatry
Genetic correlation between amyotrophic lateral sclerosis and schizophreniaNature Communications
15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculiaTranslational Psychiatry
Methylphenidate disintegration from oral formulations for intravenous use by experienced substance usersDrug and Alcohol Dependence
Truncating mutations in RBM12 are associated with psychosisNature Genetics
Reproductive fitness and genetic risk of psychiatric disorders in the general populationNature Communications
Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulationsJAMA Psychiatry
Risk of diabetes and dyslipidemia during clozapine and other antipsychotic drug treatment of schizophrenia in IcelandNordic Journal of Psychiatry
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics ConsortiumBiological Psychiatry
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System GenesScientific Reports

2016

Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in IcelandBMC Psychiatry
A new chapter [Editorial]Laeknabladid
Clozapine treatment and discontinuation in Iceland: A national longitudinal study using electronic patient recordsNordic Journal of Psychiatry
KaflaskilLæknablaðið
Intravenous Use of Prescription Psychostimulants; A Comparison of the Pattern and Subjective Experience between Different Methylphenidate Preparations, Amphetamine and CocaineEuropean Addiction Research
Multimorbidity and use of hypnotic and anxiolytic drugs: Cross-sectional and follow-up study in primary healthcare in IcelandBMC Family Practice
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication StudyPLoS Genetics

2015

Transdiagnostic cognitive behavioural treatment and the impact of co-morbidity: An open trial in a cohort of primary care patientsNordic Journal of Psychiatry
Að höggva undan sér fæturnaLæknablaðið
The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjectsMolecular Psychiatry
LD score regression distinguishes confounding from polygenicity in genome-wide association studiesNature Genetics
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk ScoresAmerican Journal of Human Genetics
Polygenic risk scores for schizophrenia and bipolar disorder predict creativityNature Neuroscience
[Destabilising the foundations of health and safety [Editorial]].
Prevalent intravenous abuse of methylphenidate among treatment-seeking patients with substance abuse disorders: A descriptive population-based studyJournal of Addiction Medicine
Prevalent Intravenous Abuse of Methylphenidate Among Treatment-Seeking Patients With Substance Abuse DisordersJournal of Addiction Medicine

2014

CNVs conferring risk of autism or schizophrenia affect cognition in controlsNature
Does the use of cannabis increase the risk for psychosis and the development of schizophrenia?,Eykur notkun kannabis hættu á gedrofi og próun gedklofa?Laeknabladid
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility geneMolecular Psychiatry
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseasesAmerican Journal of Human Genetics
Biological insights from 108 schizophrenia-associated genetic lociNature
Identification of pathways for bipolar disorder: A meta-analysisJAMA Psychiatry
Common variant at 16p11.2 conferring risk of psychosisMolecular Psychiatry
Emetophobia: Morbid fear of vomiting and nausea,Emetophobia: Sjúklegur ótti vio uppköst og ógleoiLaeknabladid
Variability inworking memory performance explained by epistasis vs polygenic scores in the ZNF804A pathwayJAMA Psychiatry

2013

A mega-Analysis of genome-wide association studies for major depressive disorderMolecular Psychiatry
Evaluation of the Psychometric Properties of the Icelandic Version of the Clinical Outcomes in Routine Evaluation-Outcome Measure, its Transdiagnostic Utility and Cross-Cultural ValidationClinical Psychology & Psychotherapy
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysisLancet
Opening Pandora's box in the UK: A hypothetical pharmacogenetic test for clozapinePharmacogenomics
All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPsPlos Genetics
Schizophrenia genetic variants are not associated with intelligencePsychological Medicine
Risk of disasters in LandspitalaLaeknabladid
Opening Pandora’s box in the UK: a hypothetical pharmacogenetic test for clozapinePharmacogenomics
[Risk of a crisis developing at Landspítali].,Hserra á neydarástandi á landspítala.Læknabladid
Genome-wide association analysis identifies 13 new risk loci for schizophreniaNature Genetics
Genetic schizophrenia risk variants jointly modulate total brain and white matter volumeBiological Psychiatry

2012

Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorderBiological Psychiatry
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from EuropeMolecular Psychiatry
Association study of nonsynonymous single nucleotide polymorphisms in schizophreniaBiological Psychiatry
Response to Boot et al. LetterAmerican Journal of Psychiatry

2011

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locusNature
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder (The American Journal of Human Genetics (2011) 88, (372-381))American Journal of Human Genetics
Developments in schizophrenia genetics: From linkage to microchips, deletions and duplicationsNordic Journal of Psychiatry
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorderAmerican Journal of Human Genetics
Common variants on 8p12 and 1q24.2 confer risk of schizophreniaNature Genetics
Copy number variations of chromosome 16p13.1 region associated with schizophreniaMolecular Psychiatry
Back to the past. Case report and review on retrograde memory lossLaeknabladid
Efficacy of cognitive behavioral therapy in the treatment of mood and anxiety disorders in adultsLaeknabladid
Early detection of prostate cancer: Is screening in general practice justifiable?Scandinavian Journal of Primary Health Care
Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illnessAmerican Journal of Psychiatry
[Human nature and the development of scientific journals].Laknabladid
[The Journal's progress and threats to the welfare of patients [Editorial]].Laknabladid
Genome-wide association study identifies five new schizophrenia lociNature Genetics
Expanding the range of ZNF804A variants conferring risk of psychosisMolecular Psychiatry
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4Nature Genetics
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 Is associated with disease risk and cortical surface areaBiological Psychiatry
At-risk variant in TCF7L2 for type II diabetes increases risk of schizophreniaBiological Psychiatry
Common variants at VRK2 and TCF4 conferring risk of schizophreniaHuman Molecular Genetics

2010

S100B Profiles and Cognitive Function at High AltitudeHigh Altitude Medicine & Biology
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohortJournal of Psychiatric Research
Catechol-o-methyltransferase val¹⁵⁸met polymorphism and antisaccade eye movements in schizophreniaSchizophrenia Bulletin
Hlutverk lækna í hagrædingu innan heilbrigdiskerfisins: Gagnsæi, ord og efndirLaeknabladid

2009

Loss, appreciation and regret,Enginn veit hvad átt hefur fyrr en misst hefurLaeknabladid
Neuregulin-1 genotypes and eye movements in schizophreniaEuropean Archives of Psychiatry and Clinical Neuroscience
[Scientific articles in the Icelandic Medical Journal 2004-2008: an overview].Laknabladid
Common variants conferring risk of schizophreniaNature
Disruption of the neurexin 1 gene is associated with schizophreniaHuman Molecular Genetics
[Public views on antidepressant treatment: lessons from a national survey].Laknabladid
COMT val158met genotype and smooth pursuit eye movements in schizophreniaPsychiatry Research
[Loss, appreciation and regret].Laknabladid
Scientific articles in the Icelandic Medical Journal 2004-2008: An overview,Hverjir skrifa í Læknablaoio?: Yfirlit yfir fræ Oigreinar sí oustu fimm áraLaeknabladid

2008

Eye movement deficits in schizophreniaEuropean Archives of Psychiatry and Clinical Neuroscience
Public views on antidepressant treatment: Lessons from a national surveyNordic Journal of Psychiatry
[Odds, fate and fortunes].Laknabladid
Vacuum-Assisted Closure for Successful Treatment of a Major Contaminated Gunshot Chest-Wound: A Case ReportEuropean Journal of Trauma and Emergency Surgery
Large recurrent microdeletions associated with schizophreniaNature

2007

Oculomotor deficits in schizophrenia: Validation of endophenotypes in a genetically homogenous Icelandic sampleEuropean Psychiatry
Support for involvement of the AHI1 locus in schizophreniaEuropean Journal of Human Genetics
Cathechol-o-methyltransferase polymorphism and eye movements in schizophreniaEuropean Neuropsychopharmacology
Cognitive function in schizophrenia and effects of neuregulin 1Schizophrenia Bulletin
Neuregulin-1 risk haplotype and eye movements in schizophreniaEuropean Neuropsychopharmacology

2006

Neuregulin-1 risk genotype and eye movements in schizophreniaAmerican Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Gene in common to schizophrenia and bipolar disorder mapped to 17q21.31-q22American Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Neuregulin 1 and cognitive function in schizophreniaSchizophrenia Research
Health-related quality of life of patients with implantable cardioverter defibrillators compared with that of pacemaker recipientsEP Europace
Neuregulin-1 and eye movements in schizophreniaSchizophrenia Research

2005

Views on antidepressants among adults in Iceland: a population-based surveyEuropean Neuropsychopharmacology

2004

The deficit syndrome of schizophrenia and neuregulin1Schizophrenia Research
Genetic loading in schizophrenia in relation to the at-risk haplotype of the NRG1 geneNordic Journal of Psychiatry
Genomics and genealogy provide an Icelandic springboard into the human gene poolJournal of Mental Health

2003

Neuregulin 1 detected as a susceptibility gene in schizophreniaNordic Journal of Psychiatry
Schizophrenia genes identified by positional cloning affect the glutamatergic systemEuropean Neuropsychopharmacology

2002

Neuregulin 1 and Susceptibility to SchizophreniaAmerican Journal of Human Genetics
Childhood motor impairment and persistent anxiety in adolescent boysEuropean Psychiatry
Are Impaired Childhood Motor Skills a Risk Factor for Adolescent Anxiety? Results From the 1958 U.K. Birth Cohort and the National Child Development StudyAmerican Journal of Psychiatry

2001

Family matters: interfaces between child and adult mental health.Acta Psychiatrica Scandinavica

1999

Neurodevelopmental delay in the severely ill - Authors' replyBritish Journal of Psychiatry
Neurodevelopmental delay in the severely ill [8] (multiple letters)British Journal of Psychiatry
Neurodevelopmental antecedents of early-onset bipolar affective disorderBritish Journal of Psychiatry

1994

VALUE OF ANTIBODIES TO GAD(65) COMBINED WITH ISLET-CELL CYTOPLASMIC ANTIBODIES FOR PREDICTING IDDM IN A CHILDHOOD POPULATIONDiabetologia
The effects of electroconvulsive therapy and depression on confabulation, memory processing, and suggestibilityNordic Journal of Psychiatry

1990

THE 64-KDA BETA-CELL MEMBRANE AUTOANTIGEN AND OTHER TARGET MOLECULES OF HUMORAL AUTOIMMUNITY IN INSULIN-DEPENDENT DIABETES-MELLITUSCurrent Topics in Microbiology and Immunology
The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitusCurrent Topics in Microbiology and Immunology

1989

PREDICTIVE VALUE OF MR 64000 ANTIBODIES FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES IN A CHILDHOOD POPULATIONDiabetologia
PREDICTIVE VALUE OF 64K ANTIBODIES FOR IDDM IN A CHILDHOOD POPULATIONScandinavian Journal of Immunology
EXPRESSION OF THE 64K AUTO-ANTIGEN AND A NOVEL TARGET OF DIABETIC AUTOANTIBODIES IN ISLETS OF DIABETES PRONE BB-RATSScandinavian Journal of Immunology

Keywords for Specialisation:

Genetics - psychiatry - epidemiology

Genetics - psychiatry - epidemiology - open online courses - personalised medicine