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Elín Soffía Ólafsdóttir - Professor
–
Heilbrigðisvísindasvið
Elín Soffía Ólafsdóttir
Íslenska
Professor
Professor of natural products chemistry
Location
Hagi / Ha-315
Phone
525 - 5804
Email
elinsol [at] hi.is
Unit
Faculty of Pharmaceutical Sciences
ORCID site
https://orcid.org/0000-0001-7305-7129
Research portal – Elín Soffía Ólafsdóttir
Courses 2024 - 2025
LYF616G - Pharmaceutical Natural Product Chemistry
LYF617G - Recently registered drugs
LYF561L - Ph.D. project
Education
1991
,
Ph.D.
,
Royal Danish School of Pharmacy
,
Pharmaceutical Sciences
1986
,
Cand. Pharm.
,
Royal Danish School of Pharmacy
,
Cand . Pharm.
1977
,
Stúdentspróf
,
Menntaskólinn í Reykjavík
,
Professional Experience
2005 -
,
Professor,
Faculty of Pharmaceutical Sciences, University of Iceland
2006 -
2009,
Dean,
Pharmaceutical Sciences, University of Iceland
2000 -
2005,
Associate Professor,
Faculty of Pharmaceutical Sciences, University of Iceland
1991 -
2000,
Assistant Professor,
Faculty of Pharmaceutical Sciences, University of Iceland
Published works
2024
The algal partnership is associated with quantitative variation of lichen specific metabolites in Cladonia foliacea from Central and Southern Europe
Symbiosis
A critical review of the edible seaweed Palmaria palmata (L.) Weber & Mohr and its bioactive compounds in the “omics” era
Algal Research
2023
Flustramine Q, a Novel Marine Origin Acetylcholinesterase Inhibitor from Flustra foliacea
Future Pharmacology
Mycobiont-specific primers facilitate the amplification of mitochondrial small subunit ribosomal DNA
MycoKeys
2022
Novel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichens
Phytochemistry
Novel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichens
Phytochemistry
2021
Invasive and in situ squamous cell carcinoma of the skin
British Journal of Dermatology
2020
Phylogenetic diversity of the lichenized algal genus Trebouxia (Trebouxiophyceae, Chlorophyta): a new lineage and novel insights from fungal-algal association patterns of Icelandic cetrarioid lichens (Parmeliaceae, Ascomycota)
Botanical Journal of the Linnean Society
Phylogenetic diversity of the lichenized algal genus Trebouxia (Trebouxiophyceae, Chlorophyta): a new lineage and novel insights from fungal-algal association patterns of Icelandic cetrarioid lichens (Parmeliaceae, Ascomycota)
Botanical Journal of the Linnean Society
Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation
Molecules
Basal cell carcinoma
British Journal of Dermatology
2019
Alkaloids fingerprinting resolves Huperzia selago genotypes in Iceland.
Biochemical Systematics and Ecology
Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes
International Immunopharmacology
Novel Approach for the Search for Chemical Scaffolds with Activity at Both Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor: A Perspective on Scaffolds with Dual Activity for the Treatment of Neurodegenerative Disorders
Molecules
Alkaloid fingerprinting resolves Huperzia selago genotypes in Iceland
Biochemical Systematics and Ecology
Ethnopharmacology of the club moss subfamily Huperzioideae (Lycopodiaceae, Lycopodiophyta)
Journal of Ethnopharmacology
Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells.
Free Radical Biology and Medicine
Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells
Free Radical Biology and Medicine
2018
Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago Complex
Planta Medica
Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors
British Journal of Pharmacology
Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS metabolite profiling and DNA barcoding.
Food Chemistry
Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS chemical profiling and DNA barcoding
Food Chemistry
2017
DNA barcoding and LC-MS metabolite profiling of the lichen-forming genus Melanelia: Specimen identification and discrimination focusing on Icelandic taxa
PLoS ONE
Investigations on the constituents of SagaPro tablets, a food supplement manufactured from Angelica archangelica leaf
Pharmazie
2016
Secondary metabolites from cetrarioid lichens
Phytomedicine
2015
The Genus Diphasiastrum and Its Lycopodium Alkaloids
Planta Medica
Cutaneous melanoma in Iceland
Journal of the European Academy of Dermatology and Venereology
Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses towards a Th2/Treg phenotype.
Phytomedicine
Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses toward a Th2/Treg phenotype
Phytomedicine
Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17
+
RORγt
+
/IL-10
+
FoxP3
+
ratio in CD4
+
T cells
Immunology Letters
2014
A heteroglycan from the cyanobacterium Nostoc commune modulates LPS-induced inflammatory cytokine secretion by THP-1 monocytes through phosphorylation of ERK1/2 and Akt
Phytomedicine
2013
Lycopodium alkaloids
Phytochemical analysis of alkaloids from the Icelandic club moss Diphasiastrum alpinum
Phytochemistry Letters
Biodiversity of benthic invertebrates and bioprospecting in Icelandic waters
Phytochemistry Reviews
Biodiversity of benthic invertebrates and bioprospecting in Icelandic waters
Phytochemistry Reviews
Structural characterisation of a complex heteroglycan from the cyanobacterium Nostoc commune
Carbohydrate Polymers
2012
Synergistic cytotoxic effect of the microtubule inhibitor marchantin a from marchantia polymorpha and the aurora kinase inhibitor MLN8237 on breast cancer cells in vitro
Planta Medica
Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro
Phytomedicine
2011
Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitro
Immunology Letters
2010
Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre
Phytochemistry
Structural characterisation of a new O-methylated heteroglycan, colleman, from the cyanolichen Collema flaccidum
Carbohydrate Polymers
Immunomodulating effects of extracts from Icelandic marine invertebrates
Planta Medica
2009
Search for the optimal dose interval of adrenocorticotrophic hormone (ACTH
1-24
) with regard to the lipid-lowering effect
Basic and Clinical Pharmacology and Toxicology
2008
In vitro and in vivo immunomodulating effects of traditionally-prepared extract and purified compounds from Cetraria islandica
Proceedings of the Nutrition Society
In vitro and in vivo immunomodulating effects of traditionally prepared extract and purified compounds from Cetraria islandica
International Immunopharmacology
In vitro and in vivo immunomodulating effects of traditonally prepared extracts and purified compounds from Cetraria islandica.
International Immunopharmacology
2007
Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformis
Phytomedicine
Alkalóíðar úr íslenskum jöfnum.
RAUST - Tímarit um raunvísindi og stærðfræði
2006
Structural characterisation of a highly branched galactomannan from the lichen Peltigera canina by methylation analysis and NMR-spectroscopy
Carbohydrate Polymers
Structural characterisation of novel heteroglycans by NMR spectroscopy and methylationanalysis.
Carbohydrate Research
Structural characterization of a highly branched galactomannan from the lichen Peltigeracanina by methylation analysis and NMR spectroscopy.
Carbohydrate Polymers
Structural characterisation of novel lichen heteroglycans by NMR spectroscopy and methylation analysis
Carbohydrate Research
Structural characterisation of novel lichen heteroglycans by NMR spectroscopy and methylation analysis.
Carbohydrate Research
Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cells
International Immunopharmacology
Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms
Atherosclerosis
Structural characterisation of a highly branched galactomannan from the lichen Peltigera canina by methylation analysis and NMR-spectroscopy.
Carbohydrate Polymers
2005
Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-α secretion by rat peritoneal macrophages in vitro
Phytomedicine
2004
Selagoline, a new alkaloid from Huperzia selago
Natural Product Research
2003
Immunologically active 06-branched (1→3)-β-glucan from the lichen Thamnolia vermicularis var. subuliformis
Phytomedicine
2002
Cyanogenic glycosides of Passiflora: Distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseutocyanogenic -hydroxyamines as isolation artefacts
Phytochemistry
Cyanogenesis in glucosinolate-producing plants
Phytochemistry
Chromatography and electrophoresis in separation and characterization of polysaccharides from lichens
Journal of Chromatography A
2001
Polysaccharides from lichens
Planta Medica
Constituents of three Icelandic Alchemilla species
Biochemical Systematics and Ecology
2000
TT virus infections among blood donors in Iceland
Transfusion
1999
Rhamnopyranosylgalactofuranan, a new immunologically active polysaccharide from Thamnolia subuliformis
Phytomedicine
Immunologically active (1→3)-(1→4)-α-D-Glucan from Cetraria islandica
Phytomedicine
1997
Comparison of NCEP performance specifications for triglycerides, HDL-, and LDL-cholesterol with operating specifications based on NCEP clinical and analytical goals
Clinical Chemistry
1996
Matrix effects and the performance and selection of quality-control procedures to monitor PO
2
measurements
Clinical Chemistry
1993
Quality Status of Serum Cholesterol Analysis in Iceland
Upsala Journal of Medical Sciences
1992
Transferability of clinical laboratory data within a health care region
Scandinavian Journal of Clinical and Laboratory Investigation
Substrate specificity in the biosynthesis of cyclopentanoid cyanohydrin glucosides
Phytochemistry
1991
Cyanohydrin glycosides with unusual sugar residues
Phytochemistry
Structure Determination of Natural Epoxycyclopentanes by X-ray Crystallography and NMR Spectroscopy
Journal of Organic Chemistry
1990
Cyanohydrin glucosides of turneraceae
Biochemical Systematics and Ecology
The Regional Transferability Project
Upsala Journal of Medical Sciences
Influence of dietary cod liver oil on fatty acid composition of plasma lipids in human male subjects after myocardial infarction
Journal of Internal Medicine
1989
Cyclopentenoid cyanohydrin glycosides with unusual sugar residues.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989)
Cyanohydrin glycosides of passifloraceae
Phytochemistry
1987
Cyanogenesis of adenia volkensii Harms and tetrapathaea tetrandra Cheeseman (Passifloraceae) revisited: tetraphyllin B and volkenin. Optical rotatory power of cyclopentenoid cyanohydrin glucosides.
Acta Chemica Scandinavica
Biochemistry in Iceland
Biochemical Education
Monohydroxylated cyclopentenone cyanohydrin glucosides of Flacourtiaceae.
Phytochemistry
1986
Natural glycosides of cyclopentenone cyanohydrins
Tetrahedron Letters
Keywords for Specialisation:
Natural product chemistry
Medicinal chemistry
Bioactive natural products
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