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Bjarni Ásgeirsson - Professor Emeritus
–
School of Engineering and Natural Sciences
Bjarni Ásgeirsson
Íslenska
Professor Emeritus
Location
Askja / N-336
Phone
525 - 4805
Email
bjarni [at] hi.is
Unit
Faculty of Physical Sciences
Website
http://www.raunvis.hi.is/~bjarni
ORCID site
https://orcid.org/0000-0002-4275-2732
Research portal – Bjarni Ásgeirsson
Courses 2024 - 2025
LEF406G - Biochemistry 2
Education
1981
,
Ph.D.
,
University of Bristol
,
1977
,
B.Sc
,
University of Bristol
,
1975
,
BS
,
University of Iceland
,
Biology
Professional Experience
2002 -
2002,
,
1991 -
2002,
,
1981 -
1991,
,
1985 -
1991,
,
Published works
2021
The high catalytic rate of the cold‐active Vibrio alkaline phosphatase requires a hydrogen bonding network involving a large interface loop
FEBS Open Bio
2020
X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamine
Biochemistry and Biophysics Reports
2019
Chloride promotes refolding of active Vibrio alkaline phosphatase through an inactive dimeric intermediate with an altered interface
FEBS Open Bio
2017
PH-Dependent Binding of Chloride to a Marine Alkaline Phosphatase Affects the Catalysis, Active Site Stability, and Dimer Equilibrium
Biochemistry
2016
Cold-active alkaline phosphatase is irreversibly transformed into an inactive dimer by low urea concentrations
Biochimica et Biophysica Acta - Proteins and Proteomics
Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: A case of promiscuous scaffolds in proteins [version 2; referees: 2 approved]
F1000Research
2015
Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions
The PDB database is a rich source of alpha-helical anti-microbial peptides to combat disease causing pathogens [v2; ref status: approved 1, http://f1000r.es/5hg]
The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins [v3; ref status: indexed, http://f1000r.es/51m]
Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: a case of promiscuous scaffolds in proteins
The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: A case of promiscuous scaffolds in proteins
F1000Research
2014
The PDB database is a rich source of alpha-helical anti-microbial peptides to combat disease causing pathogens
PREMONITION - Preprocessing motifs in protein structures for search acceleration
Correlating the ability of VP24 protein from Ebola and Marburg viruses to bind human karyopherin to their immune suppression mechanism and pathogenicity using computational methods
Promiscuous scaffolds in proteins - non-native, non-additive and non-trivial
Directed evolution induces tributyrin hydrolysis in a virulence factor of Xylella fastidiosa using a duplicated gene as a template.
F1000Research
The electrostatic profile of consecutive Cβ atoms applied to protein structure quality assessment
Correlating the ability of VP24 protein from Ebola and Marburg viruses to bind human karyopherin to their immune suppression mechanism and pathogenicity using computational methods
Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions
Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions
Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions.
F1000Research
2013
The electrostatic profile of consecutive Cβ atoms applied to protein structure quality assessment
The electrostatic profile of consecutive Cbeta atoms applied to protein structure quality assessment.
F1000Research
A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease Scaffold
Plos One
Asymmetric flexibility of a homodimeric enzyme as shown by molecular dynamics computations. A case study of the cold-active Vibrio alkaline phosphatase
Febs Journal
Protein structure quality assessment based on the distance profiles of consecutive backbone Calpha atoms.
F1000Research
Dynamics fingerprint and inherent asymmetric flexibility of a cold-adapted homodimeric enzyme. A case study of the Vibrio alkaline phosphatase
Biochimica Et Biophysica Acta-General Subjects
Dipeptidyl peptidase-IV inhibitors used in type-2 diabetes inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
F1000Research
Structural phylogeny by profile extraction and multiple superimposition using electrostatic congruence as a discriminator.
Intrinsically disordered proteins
Protein structure quality assessment based on the distance profiles of consecutive backbone Cα atoms
F1000Research
Promiscuous scaffolds in proteins - non-native, non-additive and non-trivial
Protein structure quality assessment based on the distance profiles of consecutive backbone Cα atoms
2012
Nervonic acid (24:1n-9) is a dominant unsaturated fatty acid in the intestinal brush border of atlantic cod
Lipid Insights
Inhibition of a cold-active alkaline phosphatase by imipenem revealed by in silico modeling of metallo-beta-lactamase active sites
Febs Letters
A Measure of the Broad Substrate Specificity of Enzymes Based on 'Duplicate' Catalytic Residues
Plos One
2011
Protein dynamics and temperature adaptation in extremophilic enzymes
European Biophysics Journal With Biophysics Letters
Loop connections in Vibrio alkaline phosphatase alter indicators of cold-adaptation
Febs Journal
2010
Comparison of lipid and fatty acids composition of basolateral membrane from rat (Rattus norvegicus) and Atlantic cod (Gadus morhua) intestinal enterocytes: the question of homeoviscous adaptation
Febs Journal
The role of the major loop in Vibrio alkaline phosphatase on cold-adaptation
Febs Journal
Isolation and biochemical characterisation of lipid rafts from Atlantic cod (Gadus morhua) intestinal enterocytes
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology
2009
Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopy
Febs Journal
Isolation and biochemical characterization study of lipid rafts from Atlantic cod (Gadus morhua) intestinal enterocytes
Febs Journal
The 1.4 angstrom crystal structure of the large and cold-active Vibrio sp. alkaline phosphatase
Biochimica Et Biophysica Acta-Proteins and Proteomics
2008
Effects of replacing active site residues in a cold-active alkaline phosphatase with those found in its mesophilic counterpart from Escherichia coli
Febs Journal
Isolation of lipid rafts from atlantic cod (Gadus morhua) intestinal brush border membrane
Febs Journal
2007
Engineered disulfide bonds increase active-site local stability and reduce catalytic activity of a cold-adapted alkaline phosphatase
Biochimica Et Biophysica Acta-Proteins and Proteomics
2006
Reversible inactivation of alkaline phosphatase from Atlantic cod (Gadus morhua) in urea
Biochimica Et Biophysica Acta-Proteins and Proteomics
Microscopic rate-constants for substrate binding and acylation in cold-adaptation of trypsin I from Atlantic cod
Febs Letters
2005
Introduction of a new disulfide bridge into a cold-active enzyme reduced activity while heat-stability is increased
Febs Journal
Active site mutants of Vibrio sp alkaline phosphatase
Febs Journal
2003
Amino acid sequence of the cold-active alkaline phosphatase from Atlantic cod (Gadus morhua)
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology
2001
Primary structure of cold-adapted alkaline phosphatase from a Vibrio sp as deduced from the nucleotide gene sequence
Biochimica Et Biophysica Acta-Protein Structure and Molecular Enzymology
2000
Heat-labile bacterial alkaline phosphatase from a marine Vibrio sp
Enzyme and Microbial Technology
Dissociation and unfolding of cold-active alkaline phosphatase from Atlantic cod in the presence of guanidinium chloride
European Journal of Biochemistry
1998
The third serine proteinase with chymotrypsin specificity isolated from Atlantic cod (Gadus morhua) is a type-II elastase
European Journal of Biochemistry
Hereditary cystatin C amyloid angiopathy: Monitoring the presence of the Leu-68 → Gln cystatin C variant in cerebrospinal fluids and monocyte cultures by MS
Biochemical Journal
Hereditary cystatin C amyloid angiopathy: monitoring the presence of the Leu-68 -> Gln cystatin C variant in cerebrospinal fluids and monocyte cultures by MS
Biochemical Journal
1997
Serine proteinases from cold-adapted organisms.
Advances in experimental medicine and biology
Serine proteinases from cold-adapted organisms
Advances in Experimental Medicine and Biology
Serine proteinases from cold-adapted organisms.
Advances in experimental medicine and biology
1996
Structure of chymotrypsin variant B from Atlantic cod, Gadus morhua
Biochimica Et Biophysica Acta-Protein Structure and Molecular Enzymology
1995
ALKALINE-PHOSPHATASE FROM ATLANTIC COD (GADUS-MORHUA) - KINETIC AND STRUCTURAL-PROPERTIES WHICH INDICATE ADAPTATION TO LOW-TEMPERATURES
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology
1993
PSYCHROPHILIC PROTEINASES FROM ATLANTIC COD
Acs Symposium Series
PROPERTIES OF ELASTASE FROM ATLANTIC COD, A COLD-ADAPTED PROTEINASE
Biochimica Et Biophysica Acta
Characteristics, protein engineering and applications of psychrophilic marine proteinases from Atlantic cod
Studies in Organic Chemistry
1992
ON THE ROLE OF MONOCYTES MACROPHAGES IN THE PATHOGENESIS OF CENTRAL-NERVOUS-SYSTEM LESIONS IN HEREDITARY CYSTATIN-C AMYLOID ANGIOPATHY
Journal of the Neurological Sciences
1991
The characteristics of macrophage-like cell lines derived from normal sheep spleens
FEMS Microbiology Letters
PROTEOLYTIC-ENZYMES FROM ECTOTHERMIC ORGANISMS
Abstracts of Papers of the American Chemical Society
The characteristics of macrophage-like cell lines derived from normal sheep spleens.
FEMS microbiology immunology
THE CHARACTERISTICS OF MACROPHAGE-LIKE CELL-LINES DERIVED FROM NORMAL SHEEP SPLEENS
Fems Microbiology Immunology
The characteristics of macrophage-like cell lines derived from normal sheep spleens.
FEMS microbiology immunology
STRUCTURAL AND KINETIC-PROPERTIES OF CHYMOTRYPSIN FROM ATLANTIC COD (GADUS-MORHUA) - COMPARISON WITH BOVINE CHYMOTRYPSIN
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology
1989
PURIFICATION AND CHARACTERIZATION OF TRYPSIN FROM THE POIKILOTHERM GADUS-MORHUA
European Journal of Biochemistry
Purification and characterization of trypsin from the poikilotherm Gadus morhua.
European journal of biochemistry
1984
CALCIUM-DEPENDENT PROTEIN-PHOSPHORYLATION IN BOVINE ANTERIOR-PITUITARY MEMBRANES AND INTACT-CELLS
Molecular and Cellular Endocrinology
Keywords for Specialisation:
Structure and function of proteins. Protein stability
Temperature adaptation of enzymes. Cold adaptation
Membrane lipids
Purification of biochemicals
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