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Bjarni Ásgeirsson - Professor Emeritus

Bjarni Ásgeirsson

–

School of Engineering and Natural Sciences

Bjarni Ásgeirsson

Professor Emeritus

Location
Askja / N-336
Phone
525 - 4805
Email
bjarni [at] hi.is

Unit
Faculty of Physical Sciences
Website
http://www.raunvis.hi.is/~bjarni

Published works

2022

Structural Characterization of Functionally Important Chloride Binding Sites in the Marine Vibrio Alkaline PhosphataseBiochemistry

2021

The high catalytic rate of the cold-active Vibrio alkaline phosphatase requires a hydrogen bonding network involving a large interface loopFEBS Open Bio

2020

X-ray crystal structure of Vibrio alkaline phosphatase with the non-competitive inhibitor cyclohexylamineBiochemistry and Biophysics Reports

2018

Chloride promotes refolding of active Vibrio alkaline phosphatase through an inactive dimeric intermediate with an altered interfaceFEBS Open Bio

2017

pH-Dependent Binding of Chloride to a Marine Alkaline Phosphatase Affects the Catalysis, Active Site Stability, and Dimer EquilibriumBiochemistry

2016

Cold-active alkaline phosphatase is irreversibly transformed into an inactive dimer by low urea concentrationsBiochimica et Biophysica Acta (BBA)

2015

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins [version 3; peer review: 2 approved]F1000Research
The PDB database is a rich source of alpha-helical anti-microbial peptides to combat disease causing pathogensF1000Research
Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactionsF1000Research

2014

PREMONITION - Preprocessing motifs in protein structures for search accelerationF1000Research
Directed evolution induces tributyrin hydrolysis in a virulence factor of Xylella fastidiosa using a duplicated gene as a templateF1000Research
Promiscuous scaffolds in proteins - non-native, non-additive and non-trivialF1000Research
Correlating the ability of VP24 protein from Ebola and Marburg viruses to bind human karyopherin to their immune suppression mechanism and pathogenicity using computational methodsF1000Research
The electrostatic profile of consecutive Cβ atoms applied to protein structure quality assessmentF1000Research

2013

Protein structure quality assessment based on the distance profiles of consecutive backbone Cα atomsF1000Research
Dynamics fingerprint and inherent asymmetric flexibility of a cold-adapted homodimeric enzyme. A case study of the Vibrio alkaline phosphataseBiochimica et Biophysica Acta - General Subjects
Structural phylogeny by profile extraction and multiple superimposition using electrostatic congruence as a discriminator.Intrinsically disordered proteins
A Computational Module Assembled from Different Protease Family Motifs Identifies PI PLC from Bacillus cereus as a Putative Prolyl Peptidase with a Serine Protease ScaffoldPLoS ONE

2012

Inhibition of a cold-active alkaline phosphatase by imipenem revealed by in silico modeling of metallo-β-lactamase active sitesFEBS Letters
Nervonic acid (24:1n-9) is a dominant unsaturated fatty acid in the intestinal brush border of atlantic codLipid Insights
Inhibition of a cold-active alkaline phosphatase by imipenem revealed by in silico modeling of metallo-beta-lactamase active sitesFEBS Letters
A Measure of the Broad Substrate Specificity of Enzymes Based on 'Duplicate' Catalytic ResiduesPLoS ONE

2010

Isolation and biochemical characterisation of lipid rafts from Atlantic cod (Gadus morhua) intestinal enterocytesComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

2009

Structural features and dynamics of a cold-adapted alkaline phosphatase studied by EPR spectroscopyFEBS Journal
Áhrif stökkbreytinga í hvarfstöð á hvötunarvirkni og staðbundinn hreyfanleika í stofnkeðju kuldavirks ensímsRAUST - Tímarit um raunvísindi og stærðfræði
The 1.4 Å crystal structure of the large and cold-active Vibrio sp. alkaline phosphataseBiochimica et Biophysica Acta - Proteins and Proteomics

2008

Effects of replacing active site residues in a cold-active alkaline phosphatase with those found in its mesophilic counterpart from Escherichia coliFEBS Journal

2007

Áhrif stökkbreytinga í hvarfstöð alkalísks fosfatasaRAUST - Tímarit um raunvísindi og stærðfræði
Engineered disulfide bonds increase active-site local stability and reduce catalytic activity of a cold-adapted alkaline phosphataseBiochimica et Biophysica Acta - Proteins and Proteomics

2006

Reversible inactivation of alkaline phosphatase from Atlantic cod (Gadus morhua) in ureaBiochimica et Biophysica Acta - Proteins and Proteomics
Microscopic rate-constants for substrate binding and acylation in cold-adaptation of trypsin I from Atlantic codFEBS Letters
Aðferðir til að mæla hreyfanleika í próteinum

2003

Amino acid sequence of the cold-active alkaline phosphatase from Atlantic cod (Gadus morhua)Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

2001

¹H NMR and UV-vis spectroscopy of fluorine and chlorine substituted stilbenesJournal of Molecular Structure
Primary structure of cold-adapted alkaline phosphatase from a Vibrio sp. as deduced from the nucleotide gene sequenceBiochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

2000

Heat-labile bacterial alkaline phosphatase from a marine Vibrio spEnzyme and Microbial Technology
Dissociation and unfolding of cold-active alkaline phosphatase from Atlantic cod in the presence of guanidinium chlorideEuropean Journal of Biochemistry

1998

Hereditary cystatin C amyloid angiopathyBiochemical Journal
The third, serine proteinase with chymotrypsin specificity isolated from Atlantic cod (Gadus morhua) is a type-II elastaseEuropean Journal of Biochemistry

1997

Serine proteinases from cold-adapted organismsAdvances in Experimental Medicine and Biology

1996

Structure of chymotrypsin variant B from Atlantic cod, Gadus morhuaBiochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

1995

Alkaline phosphatase from Atlantic cod (Gadus morhua). Kinetic and structural properties which indicate adaptation to low temperaturesComparative Biochemistry and Physiology -- Part B: Biochemistry and

1993

Properties of elastase from Atlantic cod a cold-adapted proteinaseBiochimica et Biophysica Acta (BBA)/Protein Structure and Molecular

1992

On the role of monocytes/macrophages in the pathogenesis of central nervous system lesions in hereditary cystatin C amyloid angiopathyJournal of the Neurological Sciences

1991

The characteristics of macrophage-like cell lines derived from normal sheep spleensFEMS Microbiology Letters
Structural and kinetic properties of chymotrypsin from atlantic cod (Gadus morhua). Comparison with bovine chymotrypsinComparative Biochemistry and Physiology -- Part B: Biochemistry and

1984

Calcium-dependent protein phosphorylation in bovine anterior pituitary membranes and intact cellsMolecular and Cellular Endocrinology

Keywords for Specialisation:

Structure and function of proteins. Protein stability

Temperature adaptation of enzymes. Cold adaptation

Membrane lipids

Purification of biochemicals