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Björn Guðbjörnsson - Professor

Björn Guðbjörnsson

–

School of Health Sciences

Björn Guðbjörnsson

Professor

Phone
5431000
Email
bgud [at] hi.is

Unit
Faculty of Medicine

Published works

2024

Patient-reported outcomes and PRO remission rates in 12,262 biologic-naïve patients with psoriatic arthritis treated with TNF-inhibitors in routine careThe Journal of rheumatology
Association of rheumatoid factor, anti-citrullinated protein antibodies and shared epitope with clinical response to initial treatment in patients with early rheumatoid arthritisAnnals of the Rheumatic Diseases
Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilansEMBO Molecular Medicine
Sex differences in patient-reported outcomes and the association with clinical factors in axial spondyloarthritis patients treated with tumour necrosis factor inhibitorsRheumatology (Oxford, England)
Patient-reported outcomes in axial spondyloarthritis and psoriatic arthritis patients treated with secukinumab for 24 months in daily clinical practiceSeminars in Arthritis and Rheumatism
Interstitial Lung Disease in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Initiating Biologics and ControlsThe Journal of rheumatology
Drug effectiveness of 2nd and 3rd TNF inhibitors in psoriatic arthritis – relationship with the reason for withdrawal from the previous treatmentJoint Bone Spine
Effectiveness of secukinumab in radiographic and non-radiographic axial spondyloarthritisRMD Open
Obesity is a risk factor for poor response to treatment in early rheumatoid arthritisRMD Open
Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritisArthritis research & therapy
Comparing DAPSA, DAPSA28, and DAS28-CRP in Patients With Psoriatic Arthritis Initiating a First Tumor Necrosis Factor Inhibitor Across Nine European CountriesArthritis Care and Research
Circulating Baseline CXCR3⁺Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid ArthritisACR Open Rheumatology
Nationwide prevalence of glucocorticoid prescriptions over 17 years and osteoporosis prevention among long-term usersSAGE Open Medicine
Prescription of non-steroidal anti-inflammatory drugs for patients with inflammatory arthritis decreases with the initiation of tumour necrosis factor inhibitor therapyScandinavian Journal of Rheumatology
Enthesitis in a European registry-based cohort of patients with psoriatic arthritis treated with tumour necrosis factor inhibitorsScandinavian Journal of Rheumatology

2023

Second and third TNF inhibitors in European patients with axial spondyloarthritisRheumatology (Oxford, England)
Uptake and effectiveness of newer biologic and targeted synthetic disease-modifying antirheumatic drugs in psoriatic arthritisAnnals of the Rheumatic Diseases
Corrigendum to ‘Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: data from the EuroSpA collaboration’ [Seminars in Arthritis and Rheumatism 56 (2022) 1-13/152081]Seminars in Arthritis and Rheumatism
Methotrexate safety and efficacy in combination therapies in patients with early rheumatoid arthritisArthritis and Rheumatology
Comment onRheumatology (United Kingdom)
Commonalities and differences in set-up and data collection across European spondyloarthritis registries — results from the EuroSpA collaborationArthritis Research and Therapy
Exposure to specific tumour necrosis factor inhibitors and risk of demyelinating and inflammatory neuropathy in cohorts of patients with inflammatory arthritisRMD Open
Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogenRheumatology (Oxford, England)
Sex differences in the effectiveness of first-line tumor necrosis factor inhibitors in psoriatic arthritis; results from the EuroSpA Research Collaboration NetworkArthritis & rheumatology (Hoboken, N.J.)
Predictors of DAPSA28 remission in patients with psoriatic arthritis initiating a first TNF-inhibitorRheumatology (Oxford, England)
Sex differences in the effectiveness of first-line tumour necrosis factor inhibitors in axial spondyloarthritisRMD Open
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritisAnnals of the Rheumatic Diseases
Differences and similarities between the EULAR/ASAS-EULAR and national recommendations for treatment of patients with psoriatic arthritis and axial spondyloarthritis across EuropeThe Lancet Regional Health - Europe
One-Third of European Patients with Axial Spondyloarthritis Reach Pain Remission With Routine Care Tumor Necrosis Factor Inhibitor TreatmentThe Journal of rheumatology

2022

Real-World Six- and Twelve-Month Drug Retention, Remission, and Response Rates of Secukinumab in 2,017 Patients With Psoriatic Arthritis in Thirteen European CountriesArthritis Care and Research
Do patient-reported measures of disease activity in rheumatoid arthritis vary between countries?Rheumatology (Oxford, England)
Blood chemokine levels are markers of disease activity but not predictors of remission in early rheumatoid arthritisClinical and Experimental Rheumatology
Is the risk of infection higher during treatment with secukinumab than with TNF-inhibitors?Rheumatology (Oxford, England)
A patients’ perspective towards the injection devices for Humira® and Imraldi® in a Nationwide witching programFrontiers in Medicine
A Patients' Perspective Towards the Injection Devices for Humira® and Imraldi® in a Nationwide Switching ProgramFrontiers in Medicine
The occurrence of multiple treatment switches in axial spondyloarthritis. Results from five Nordic rheumatology registries.Rheumatology (Oxford, England)
Aldarafmæli D-vítamínsLæknablaðið
Short-term, intermediate-term and long-term risks of acute coronary syndrome in cohorts of patients with RA starting biologic DMARDsAnnals of the Rheumatic Diseases
One-Year Treatment Outcomes of Secukinumab Versus Tumor Necrosis Factor Inhibitors in SpondyloarthritisArthritis and Rheumatism
Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogenRheumatology
Correction toRheumatology (Oxford, England)
The impact of a csDMARD in combination with a TNF inhibitor on drug retention and clinical remission in axial spondyloarthritisRheumatology (Oxford, England)
Sex differences in remission rates over 24 weeks among three different biological treatments compared to conventional therapy in patients with early rheumatoid arthritis (NORD-STAR)The Lancet Rheumatology
Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitorsSeminars in Arthritis and Rheumatism
Haematological malignancies in patients with psoriatic arthritis overall and treated with TNF inhibitorsRMD Open

2021

Sarcoidosis in Iceland. Epidemiology, clinical symptoms and environmental exposure.ERJ Open Research
HLA-B*27 is significantly enriched in Nordic patients with psoriatic arthritis mutilansClinical and Experimental Rheumatology
Risafrumuæðabólga – sjúkratilfelli með drepi í hársverði og skyndiblinduLæknablaðið
Risk of solid cancers overall and by subtypes in patients with psoriatic arthritis treated with TNF inhibitors - a Nordic cohort studyRheumatology (Oxford, England)
European bio-naïve spondyloarthritis patients initiating TNFiRheumatology (Oxford, England)
Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaborationAnnals of the Rheumatic Diseases
Plasma interferon-alpha is associated with double-positivity for autoantibodies but is not a predictor of remission in early rheumatoid arthritis—a spin-off study of the NORD-STAR randomized clinical trialArthritis Research and Therapy
Inflammatory hallmarks of lesser prominence in psoriatic arthritis patients starting biologicsRheumatology (United Kingdom)
Sarcoidosis in IcelandERJ Open Research
Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritisRheumatology
Prevalence, admission rates and hypoxia due to COVID-19 in patients with rheumatic disorders treated with targeted synthetic or biologic disease modifying antirheumatic drugs or methotrexateAnnals of the Rheumatic Diseases
Comorbidities in a Cohort of 66 Patients With Psoriatic Arthritis Mutilans—Results From the Nordic PAM StudyFrontiers in Medicine
Risafrumuæðabólga – sjúkratilfelli með drepi í hársverði og skyndiblinduLæknablaðið
Comparison of treatment retention and response to secukinumab versus tumour necrosis factor inhibitors in psoriatic arthritisRheumatology (Oxford, England)
Outpatient Use of Antimicrobials in Patients With Rheumatoid Arthritis Before and After Treatment With Tumor Necrosis Factor Inhibitors: A Nationwide Retrospective Cohort StudyACR Open Rheumatology
Resolution of Th/Tc17-driven inflammation during anti-TNF alpha treatment of rheumatoid arthritis reveals a unique immune biomarker profiling patternScandinavian Journal of Immunology
Effectiveness of a second biologic after failure of a non–tumor necrosis factor inhibitor as first biologic in rheumatoid arthritisJournal of Rheumatology
HLA-B*27 is significantly enriched in the Nordic Psoriasis Arthritis Mutilans population compared with Psoriasis Arthritis without Mutilation.Clinical and Experimental Rheumatology
Infliximab-induced liver injuryJournal of Hepatology
Risaæðafrumubólga – sjúkratilfelli með drep í hársverði og skyndiblinduLæknablaðið

2020

Radiographic scoring systems for psoriatic arthritis are insufficient for psoriatic arthritis mutilans: results from the Nordic PAM Study.Acta radiologica open
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid diseaseNature
Outcomes and safety of tumor necrosis factor inhibitors in reactive arthritisJournal of Rheumatology
Active conventional treatment and three different biological treatments in early rheumatoid arthritisThe BMJ
Impact of discordance between patient's and evaluator's global assessment on treatment outcomes in 14 868 patients with spondyloarthritisRheumatology (United Kingdom)
Retention and response rates in 14 261 PsA patients starting TNF inhibitor treatment - Results from 12 countries in EuroSpARheumatology (United Kingdom)
Impact of discordance between patient’s and evaluator’s global on TNFi retention and remission in 14868 spondyloarthritis patientsRheumatology
Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment: routine care data from 13 registries in the EuroSpA collaborationRMD Open
How do we use biologics in rheumatoid arthritis patients with a history of malignancy? An assessment of treatment patterns using Scandinavian registersRMD Open

2019

Fæðingarsaga íslenskra kvenna með gigtarsjúkdóma og líftæknilyfjameðferð.Læknablaðið
Fæðingarsaga kvenna með alvarlega liðbólgusjúkdóma: Niðurstöður frá ICEBIO og FæðingaskráLæknablaðið
Treatment retention of infliximab and etanercept originators versus their corresponding biosimilars: Nordic collaborative observational study of 2334 biologics naïve patients with spondyloarthritisRMD Open
Clinical decision support system in osteoporosis in comparison to NOGG guidelines and an osteology specialist.BMC Medical Informatics and Decision Making
Clinical decision support system for the management of osteoporosis compared to NOGG guidelines and an osteology specialist: a validation pilot studyBMC Medical Informatics and Decision Making
Treatment response and drug retention rates in 24 195 biologic-naïve patients with axial spondyloarthritis initiating TNFi treatmentAnnals of the Rheumatic Diseases
Fæðingarsaga kvenna með alvarlega liðbólgusjúkdómaLæknablaðið
Pregnancy outcomes in Icelandic female patients with inflammatory arthritides. Nationwide results from the ICEBIO and the Icelandic Medical Birth RegisterLæknablaðið
Patients with psoriatic arthritis who are not eligible for randomized clinical trials for TNF inhibitors have similar treatment response and drug survival.RMD Open
Patients with psoriatic arthritis who are not eligible for randomised controlled trials for TNF inhibitors have treatment response and drug survival similar to those who are eligibleRMD Open

2018

Opportunities and challenges for Real-World studies on chronic inflammatory joint diseases through data enrichment and collaboration between national registersRMD Open
Low starting dosage of in iximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registryJournal of Psoriasis and Psoriatic Arthritis
Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016Scandinavian Journal of Rheumatology
The majority of patients with psoriatic arthritis are not eligible for randomised clinical trialsClinical and Experimental Rheumatology
Þvagsýrugigt - læknanleg liðbólgaLæknablaðið
Skimun fyrir berklum meðal gigtarsjúklinga sem hófu meðferð með TNFa-hemlum á Íslandi 1999-2014Læknablaðið
Þvagsýrugigt - læknanleg liðbólgaLæknablaðið
Skimun fyrir berklum meðal gigtarsjúklinga sem hófu meðferð með TNFα-hemlum á Íslandi 1999-2014Læknablaðið

2017

Disease activity in and quality of life of patients with psoriatic arthritis mutilansScandinavian Journal of Rheumatology
Corrigendum to "A Clinical Decision Support System for the Diagnosis, Fracture Risks and Treatment of Osteoporosis"Computational and Mathematical Methods in Medicine
Eight-year follow-up of airway hyperresponsiveness in patients with primary Sjögren’s syndromeUpsala Journal of Medical Sciences
Drug-Induced Autoimmune HepatitisClinical Gastroenterology and Hepatology
Head-to-head comparison of aggressive conventional therapy and three biological treatments and comparison of two de-escalation strategies in patients who respond to treatmentTrials
GRAPPA trainees symposium 2016Journal of Rheumatology

2016

Psoriatic Arthritis Mutilans (PAM) i NordenBest Practice
The influence of obesity on response to tumour necrosis factor-α inhibitors in psoriatic arthritisRheumatology (United Kingdom)
Activation of Complement Following Total Hip ReplacementScandinavian Journal of Immunology

2015

Radiographic development during three decades in a patient with psoriatic arthritis mutilans.Acta radiologica open
Risk of drug-induced liver injury from tumor necrosis factor antagonistsClinical Gastroenterology and Hepatology

2014

Impact of different infliximab dose regimens on treatment response and drug survival in 462 patients with psoriatic arthritisRheumatology (United Kingdom)

2013

Sarcoid arthropathy and the association with the human leukocyte antigen. the icelandic sarcoidosis studyClinical and Experimental Rheumatology
Siðfræðilegt og lögformlegt umhverfi vísindarannsókna á heilbrigðissvið.
Psoriatic arthritis mutilans (PAM) in the Nordic countriesScandinavian Journal of Rheumatology
Arthritis mutilansJournal of Rheumatology

2012

Psoriatic arthritis and onycholysis - Results from the cross-sectional reykjavik psoriatic arthritis studyJournal of Rheumatology

2010

Risafrumuæðabólga. Tvö sjúkratilfelli með skyndiblinduLaeknabladid
A strong familiality of ankylosing spondylitis through several generationsAnnals of the Rheumatic Diseases
Rofecoxib, but not celecoxib, increases the risk of thromboembolic cardiovascular events in young adults - A nationwide Registry-based studyEuropean Journal of Clinical Pharmacology
Prevalence and clinical characteristics of ankylosing spondylitis in Iceland - A nationwide studyClinical and Experimental Rheumatology
Small joint involvement in psoriatic arthritis is associated with onycholysisScandinavian Journal of Rheumatology

2009

A strong heritability of psoriatic arthritis over four generations--the Reykjavik Psoriatic Arthritis Study.Rheumatology (Oxford, England)
Lífsgæði og lífsgæðarannsóknirTímarit hjúkrunarfræðinga

2008

Are ethics rules too strict in retrospective clinical studies?Acta Ophthalmologica
Effects of two years of daily teriparatide treatment on BMD in postmenopausal women with severe osteoporosis with and without prior antiresorptive treatment.Journal of Bone and Mineral Research
Diurnal rhythm of cytokines in rheumatoid arthritis may be reflected in in vitro cultures of collected mononuclear cellsClinical and Experimental Rheumatology
Rib cage motion in ankylosing spondylitis patientsSpine Journal
Effects of previous antiresorptive therapy on the bone mineral density response to two years of teriparatide treatment in postmenopausal women with osteoporosis.Journal of Clinical Endocrinology and Metabolism

2007

Beina- og kalkbúskapur sjúklinga med herslismein.Læknabladid
Psoriasis Arthritis is more common and has earlier age of onset in women in the Icelandic population.Journal of Rheumatology
Inflammatory cytokines in relation to adrenal response following total hip replacementScandinavian Journal of Immunology
Clinical manifestation, prevalence and prognosis of sarcoid arthropathy a nationwide studySarcoidosis Vasculitis and Diffuse Lung Diseases

2005

Ultrastructure of bronchial biopsies from patients with allergic and non-allergic asthmaRespiratory Medicine
Circulating adhesion molecules in allergic and non-allergic asthmaRespiratory Medicine

2004

Synovial concentration of the angiogenic peptides bFGF and VEGF are elevated, but do not discriminate between different forms of inflammation.Scandinavian Journal of Clinical and Laboratory Investigation
Synovial concentrations of the angiogenic peptides bFGF and VEGF do not discriminate rheumatoid arthritis from other forms of inflammatory arthritisScandinavian Journal of Clinical and Laboratory Investigation

2003

Siðferðilegt og lögformlegt umhverfi vísindarannsókna á heilbrigðissviði.

2002

Prevalence of long term steroid treatment and the frequency of decision making to prevent steroid induced osteoporosis in daily clinical practiceAnnals of the Rheumatic Diseases
Steroids cause osteoporosis [1] (multiple letters)Annals of the Rheumatic Diseases
Forvarnir og meðferð beinþynningar af völdum sykurstera : klínískar leiðbeiningarLæknablaðið

2001

Sleep disturbances in patients with systemic lupus erythematosusClinical and Experimental Rheumatology
Orsakir langtímasykursteranotkunar á Íslandi og algengi forvarna gegn beinþynninguLæknablaðið
Inflammation and structural changes in the airways of patients with primary Sjögren's syndromeRespiratory Medicine

2000

Sleep disturbances in outpatients with ankylosing spondylitis - A questionnaire study with gender implicationsScandinavian Journal of Rheumatology
Psychological well-being in patients with primary Sjogren's syndromeClinical and Experimental Rheumatology
Segamyndun í djúpum bláæðum ganglima : uppgjör frá FSA 1975-1990Læknablaðið
Algengi augn- og munnþurrks á Íslandi með hliðsjón af heilkenni SjögrensLæknablaðið
Different airway responsiveness profiles in atopic asthma, nonatopic asthma, and Sjogren's syndromeAllergy: European Journal of Allergy and Clinical Immunology
Anxiety and depression in patients with primary Sjogren's syndromeJournal of Rheumatology
Segamyndun í djúpvenum ganglima. Uppgjör frá FSA 1975-1990.Læknablaðið
COX-2 í stað NSAID, borgar það sig? [ritstjórnargrein]Læknablaðið

1999

Serum lysozymeRheumatology
Increased nitric oxide in expired air in patients with Sjogren's syndromeEuropean Respiratory Journal
Tiredness, sleep disturbances and pulmonary involvement in patients with primary Sjögren´s syndrome.Hygiea
Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthmaRespiratory Medicine

1998

Enhanced neutrophilic and eosinophilic adhesion in patients with primary Sjögren´s syndrome.Clinical and Experimental Rheumatology
Concordant Message of Different Inflammatory Markers in Patients with Rheumatoid ArthritisUpsala Journal of Medical Sciences
Concordant massege of different inflammation markers in patients with rheumatoid arthritis.Upsala Journal of Medical Sciences
Enhanced neutrophil and eosinophil adhesion in patients with primary Sjogren's syndromeClinical and Experimental Rheumatology
Mycket god korrelation mellan olika inflammationsmarkörer hos patienter med reumatoid artrit.Klinisk Kemi

1997

Anti-inflammatory drugs do not alleviate bronchial hyperreactivity in Sjogren's syndromeAllergy: European Journal of Allergy and Clinical Immunology
The timing of glucocorticoid administration in rheumatoid arthritisAnnals of the Rheumatic Diseases

1996

Intact adrenocorticotropic hormone secretion but impaired cortisol response in patients with active rheumatoid arthritis. Effect of glucocorticoidsJournal of Rheumatology

1995

Clinical and experimental studies in primary sjogren's syndromeScandinavian Journal of Rheumatology

1994

Phenotypic and functional activation of alveolar macrophages, T lymphocytes and NK cells in patients with systemic sclerosis and primary Sjogren's syndromeAnnals of the Rheumatic Diseases
Postpartum thyroiditis and Sjögren's syndrome.Sjögren's syndrome - State of the art.
Sleeping habits of patients with primary Sjögren's syndrome in comparison with healthy controls and patients with other rheumatic diseases.Sjögren's syndrome - State of the art.
Circadian rhythm of serum interleukin-6 in rheumatoid arthritisAnnals of the Rheumatic Diseases
Clinical and laboratory features of Sjogren's syndrome in young women with previous postpartum thyroiditisJournal of Rheumatology

1993

Sleep disturbances in patients with primary sjögren's syndromeRheumatology

1992

Sjögren's syndrome and inflammatory bowel diseasesRheumatology
T‐Cell Receptor V‐Gene Usage in Synovial Fluid and Synovial Tissue from RA PatientsScandinavian Journal of Immunology
Rauðkornavaki gegn blóðskorti af völdum langvinnrar liðagigtarLæknablaðið
Response of anaemia in rheumatoid arthritis to treatment with subcutaneous recombinant human erythropoietinAnnals of the Rheumatic Diseases
Rauðkornavaki gegn blóðskorti af völdum langvinnar liðagigtar.Læknablaðið
Bronchial hyperresponsiveness to methacholine in primary Sjogren's syndrome [2]Annals of the Rheumatic Diseases

1991

Neutrophil function in patients with primary Sjögren's syndromeAnnals of the Rheumatic Diseases
Anemia of chronic inflammatory arthritides: Treatment with recombinant human erythropoietin.Contributions to Nephrology
Hypoxanthine, xanthine, and urate in synovial fluid from patients with inflammatory arthritidesAnnals of the Rheumatic Diseases
Deposition of eosinophil cationic protein in vascular lesions in temporal arteritisAnnals of the Rheumatic Diseases
Bronchial hyperresponsiveness to methacholine in patients with primary Sjogren's syndromeAnnals of the Rheumatic Diseases

1990

Cutaneous polyarteritis nodosa associated with Crohn's disease. Report and review of the literatureJournal of Rheumatology

1987

Lungnabólga. Orsakir og gildi greiningaraðferða.Læknablaðið
Painful Autoimmune Thyroiditis Occurring on Amiodarone TherapyActa Medica Scandinavica

1986

Hjartaþræðingar á Íslandi. Yfirlit yfir 2000 fyrstu rannsóknirnar.Læknablaðið

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Rheumatology and Clinical Databases