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Rafn Benediktsson - Prófessor

Rafn Benediktsson

–

Heilbrigðisvísindasvið

Rafn Benediktsson

Prófessor

Yfirlæknir innkirtlalækninga

Aðsetur
LSH - Fossvogi
Sími
543 1000
Tölvupóstur
rafn [hjá] hi.is

Starfseining
Læknadeild
Vefsíða
http://www.uni.hi.is/rafn

ORCID vefsíða
https://orcid.org/0000-0002-2954-9801
Rannsóknagátt – Rafn Benediktsson

Útgefið efni

2021

Distinction between the effects of parental and fetal genomes on fetal growth.Nature genetics
Loss-of-Function Variants in the Tumor-Suppressor Gene PTPN14 Confer Increased Cancer Risk.Cancer research
[Obesity of a Nation - what can we do?]Laeknabladid
Caffeine exposure from beverages and its association with self-reported sleep duration and quality in a large sample of Icelandic adolescents.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2020

FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.Nature

2019

The Number of Adults with Incident Type 1 Diabetes Phenotype in Iceland is Half the Number in Children - a Population Based Study.Diabetes research and clinical practice
Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures (Nature Communications, (2019), 10, 1, (2054), 10.1038/s41467-019-09860-0)Nature Communications
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.Nature communications
A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy.Nature communications

2018

Sequence variants associating with urinary biomarkersHuman molecular genetics
[Opioid Induced Pituitary Dysfunction].Laeknabladid
Opioid induced pituitary dysfunction,Sjúkratilfelli Truflun á starfsemi heiladinguls vegna ópíóíðaLaeknabladid

2017

Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability.Nature genetics
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.Diabetes
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlationsNPJ genomic medicine

2015

The epidemiology of pituitary adenomas in Iceland, 1955-2012: A nationwide population-based studyEuropean Journal of Endocrinology
The epidemiology of pituitary adenomas in Iceland, 1955-2012: a nationwide population-based study.European journal of endocrinology
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.Nature genetics
HbA1c 7% verður 53 mmól/mól ný eining frá 1. mars 2015
HbA1c 7% verour 53 mmól/mól -ný eining frá 1. mars 2015Laeknabladid

2014

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Nature genetics
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.Nature genetics
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.PLoS genetics
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.Nature genetics
Adipose tissue, muscle, and function: potential mediators of associations between body weight and mortality in older adults with type 2 diabetes.Diabetes care
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.Cell
Frá embætti landlæknis. Vanstarfsemi í skjaldkirtliLaeknabladid

2013

Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studies.BMC public health
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.Diabetes
The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry.Nutrition, metabolism, and cardiovascular diseases : NMCD
Genome-wide association study identifies three novel loci for type 2 diabetes.Human molecular genetics

2012

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.PLoS genetics
[Early life residency associated with the risk of developing type 2 diabetes - the population-based Reykjavík study].Laeknabladid
[Diagnosis and management of hypertension].,Greining, medferd og eftirlit háprýstings.Læknabladid
Greining, meofero og eftirlit há\+rýstingsLaeknabladid
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.PLoS genetics
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Nature genetics
Circadian gene variants and susceptibility to type 2 diabetes: a pilot study.PloS one
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.PLoS genetics
A genome-wide association search for type 2 diabetes genes in African Americans.PloS one
[Diagnosis and management of hypertension].Laeknabladid
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.Nature genetics
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.PLoS genetics
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.Human molecular genetics
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.Diabetes
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.Diabetes
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.Nature genetics
Early life residency associated with the risk of developing type 2 diabetes - The population-based Reykjavík Study,Tengsl búsetu fyrstu 20 æviárin vid áhættu á sykursýki af tegund 2Laeknabladid

2011

Retinopathy in old persons with and without diabetes mellitus: the Age, Gene/Environment Susceptibility--Reykjavik Study (AGES-R).Diabetologia
Treatment of type 1 diabetes in adults - Problem solved?,Meohöndlun sykursýki af tegund 1 hjá fulloronum - er búio ao leysa málio?Laeknabladid
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1American Journal of Human Genetics
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.Diabetes
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.Nature genetics
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.Nature genetics
The Lin28/let-7 axis regulates glucose metabolism.Cell
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes.Nature genetics
Effects of statin medication on mortality risk associated with type 2 diabetes in older persons: the population-based AGES-Reykjavik Study.BMJ open
[Treatment of type 1 diabetes in adults - problem solved?].Laeknabladid
Erratum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisNature Genetics
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.Diabetes
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.PLoS genetics

2010

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Nature genetics
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))Nature Genetics
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.Nature genetics

2009

Unfavourable risk factors for type 2 diabetes mellitus are already apparent more than a decade before onset in a population-based study of older persons: from the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik).European journal of epidemiology
[Self-care and empowerment in diabetes care: use of instruments in clinical practice - a review].Laeknabladid
Instruments to tailor care of people with type 2 diabetes.Journal of advanced nursing
Self-care and empowerment in diabetes care: Use of instruments in clinical practice - a review,Sjálfsumönnun og sjálfsefling fólks meö sykursýki Tillaga aö nálgun meö leiöbeinandi matskvöröum - yfirlitsgreinLaeknabladid
Parental origin of sequence variants associated with complex diseases.Nature

2008

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.Nature genetics
Foot disease in Icelandic patients with established type 2 diabetes,Einkenni og teikn fótameins hjá iś lenskum sjú lingum meǒsý kursy ki af tegund 2Laeknabladid
[Foot disease in Icelandic patients with established type 2 diabetes].Laeknabladid

2007

Once-daily sitagliptin, a dipeptidyl peptidase-4 inhibitor, for the treatment of patients with type 2 diabetes.Current medical research and opinion
[Prevalence of type 2 diabetes mellitus in Iceland 1967-2002].Laeknabladid
Infant feeding patterns and midlife erythrocyte sedimentation rate.Acta paediatrica (Oslo, Norway : 1992)
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.Nature genetics
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.Nature genetics
Prevalence of type 2 diabetes mellitus in Iceland 1967-2002,Algengi sykursýki af tegund tvö á Islandi 1967-2002.Læknabladid
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.Nature genetics
Outcomes of educational interventions in type 2 diabetes: WEKA data-mining analysis.Patient education and counseling

2006

Reliability and validity of the Icelandic version of the Problem Area in Diabetes (PAID) Scale.International journal of nursing studies
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.Nature genetics

2005

Latent autoimmune diabetes in adults in Iceland: prevalence, phenotype and relatedness,Mótefnatengd sykursýki af tegund 2 á Islandi: algengi, svipgerd og skyldleiki einstaklinga.Læknabladid
Mótefnatengd sykursýki af tegund 2 á Íslandi : algengi, svipgerð og skyldleiki einstaklinga
[Latent autoimmune diabetes in adults in Iceland: prevalence, phenotype and relatedness].Laeknabladid

2004

Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population.European journal of clinical nutrition
Maximizing the benefit of treatment in mild hypertension:three simple steps to improve diagnostic accuracy.QJM : monthly journal of the Association of Physicians

2003

Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.American journal of human genetics
[Three simple steps for improving diagnostic accuracy in hypertension.].Laeknabladid

2002

Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight populationAmerican Journal of Clinical Nutrition
[Hypertension with hypokalemia: unusual presentation of pheochromocytoma - case report.].Laeknabladid
Size at birth and coronary artery disease in a population with high birth weight.The American journal of clinical nutrition
Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population.The American journal of clinical nutrition
Size at birth and coronary artery disease in a population with high birth weightAmerican Journal of Clinical Nutrition
Relationship between size at birth and hypertension in a genetically homogeneous population of high birth weight.Journal of hypertension

2000

Transfer and metabolism of prostaglandin E(2)in the dual perfused human placenta.Placenta

1998

Tissue-specific messenger ribonucleic acid expression of 11beta-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor within rat placenta suggests exquisite local control of glucocorticoid action.Endocrinology
Meðferð sykursýki af tegund 2 : bresk tímamótarannsókn styður góða blóðsykur- og blóðþrýstingsstjórn [ritstjórnargrein]
Management of the unexpected result: compensated hypothyroidism.Postgraduate medical journal
Understanding human parturition [6]Lancet
Understanding human parturition.Lancet (London, England)

1997

Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure.Clinical endocrinology
Lack of effect of nicotine or ethanol on the activity of 11β- hydroxysteroid dehydrogenase type 2Journal of Steroid Biochemistry and Molecular Biology
Lack of effect of nicotine or ethanol on the activity of 11beta-hydroxysteroid dehydrogenase type 2.The Journal of steroid biochemistry and molecular biology

1996

11beta-Hydroxysteroid dehydrogenase type 2 in the rat corpus luteum: induction of messenger ribonucleic acid expression and bioactivity coincident with luteal regression.Endocrinology
11 beta-Hydroxysteroid dehydrogenases: tissue-specific dictators of glucocorticoid action.Essays in biochemistry
11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects.Steroids
11β-Hydroxysteroid dehydrogenases: Key enzymes in determining tissue-specific glucocorticoid effectsSteroids
Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the ratPlacenta
Essential hypertension: should we operate?Clinical endocrinology
Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat.Placenta
11beta-Hydroxysteroid dehydrogenase type 2 in the rat corpus luteum: induction of messenger ribonucleic acid expression and bioactivity coincident with luteal regression.Endocrinology
11β-Hydroxysteroid dehydrogenases: Tissue-specific dictators of glucocorticoid actionEssays in Biochemistry

1995

Ambulatory blood pressure monitoring: From research to clinical practiceJournal of Human Hypertension
Placental 11 beta-hydroxysteroid dehydrogenase and the programming of hypertension.The Journal of steroid biochemistry and molecular biology
The role of 11beta-hydroxysteroid dehydrogenase in controlling foetal glucocorticoid exposure
Cellular selectivity of aldosterone action: role of 11 beta-hydroxysteroid dehydrogenase.Current opinion in nephrology and hypertension
Cellular selectivity of aldosterone action: Role of 11 beta-hydroxysteroid dehydrogenaseCurrent Opinion in Nephrology and Hypertension
Placental 11β-hydroxysteroid dehydrogenase and the programming of hypertensionJournal of Steroid Biochemistry and Molecular Biology
Fetal osteocalcin levels are related to placental 11 beta-hydroxysteroid dehydrogenase activity in humans.Clinical endocrinology
Ambulatory blood pressure monitoring: from research to clinical practice.Journal of human hypertension

1994

Apparent mineralocorticoid excess.Journal of human hypertension
Apparent mineralocorticoid excessJournal of Human Hypertension

1993

Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?Lancet (London, England)
Glucocorticoid exposure in utero: new model for adult hypertension.Lancet (London, England)
Congenital and acquired syndromes of apparent mineralocorticoid excessJournal of Steroid Biochemistry and Molecular Biology
Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?The Lancet
Congenital and acquired syndromes of apparent mineralocorticoid excess.The Journal of steroid biochemistry and molecular biology

1992

11 beta-Hydroxysteroid dehydrogenase in the rat ovary: high expression in the oocyte.The Journal of endocrinology
11β-Hydroxysteroid dehydrogenase in the rat ovary: High expression in the oocyteJournal of Endocrinology
Dexamethasone treatment of pregnant rats leads to raised blood pressure in the offspringJournal of Hypertension
Blood pressure and birth weight: Is fetal glucocorticoid exposure the missing link?Journal of Hypertension

1991

Natural history of chronic left ventricular aneurysm; a population based cohort study.Journal of clinical epidemiology
Natural history of chronic left ventricular aneurysm; A population based cohort studyJournal of Clinical Epidemiology
Liquorice.Lancet (London, England)

1989

Áhrif lýsis á hjarta- og æðasjúkdóma.

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