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Forsíða

Forsíða

Eiríkur Steingrímsson - Professor

Eiríkur Steingrímsson

–

School of Health Sciences

Eiríkur Steingrímsson

Professor

Location
Sturlugata 8
Phone
525 - 4270
Email
eirikurs [at] hi.is

Unit
Biochemistry

Published works

2024

Mitf regulates gene expression networks implicated in B cell homeostasis, germinal center responses, and toleranceFrontiers in Immunology
Novel mechanisms of MITF regulation identified in a mouse suppressor screenEMBO Reports
ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy MetabolismTraffic

2023

Acetylation reprograms MITF target selectivity and residence timeNature Communications

2022

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genesPLoS Genetics
Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62Scientific Reports
Hedgehog signalling in bone and osteoarthritisFEBS Journal

2021

Epigenetic regulation during melanocyte development and homeostasisExperimental Dermatology
Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanismsAmerican Journal of Human Genetics
Mitf reprograms the extracellular matrix and focal adhesion in melanomaeLife
User guide to MiT-TFE isoforms and post-translational modificationsPigment Cell and Melanoma Research
Diffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndromeScandinavian Journal of Rheumatology
BRN2 is a non-canonical melanoma tumor-suppressorNature Communications

2020

Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1Clinical Genetics
Melanoma risk and melanocyte biologyActa Dermato-Venereologica
Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic PlasticityeNeuro
Tuning Transcription Factor Availability through Acetylation-Mediated Genomic RedistributionMolecular Cell
MITF and TFEB cross-regulation in melanoma cellsPLoS ONE
Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motifNucleic Acids Research
The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye functionScientific Reports

2019

MITF has a central role in regulating starvation-induced autophagy in melanomaScientific Reports
Subcellular localization and stability of MITF are modulated by the bHLH-Zip domainPigment Cell and Melanoma Research
Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanomaPharmacoepidemiology and Drug Safety
MITF has a central role in regulating starvation-induced autophagy in melanomaScientific Reports
Distribution of mast cells within the mouse heart and its dependency on MitfMolecular Immunology
The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye functionScientific Reports
Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual diseaseCancer Research
The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye functionScientific Reports

2018

Proton-pump inhibitors among adults: a nationwide drug-utilization study.Therapeutic Advances in Gastroenterology
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritisNature Genetics
Proton-pump inhibitors among adultsTherapeutic Advances in Gastroenterology
A short isoform of ATG7 fails to lipidate LC3/GABARAPScientific Reports
Erratum toScientific Reports
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear exportProceedings of the National Academy of Sciences

2017

Dægurklukkan og Nóbelsverðlaunin í lífeðlis- og læknisfræði 2017Læknablaðið
An eye on microphthalmiaPigment cell & melanoma research
Dægurklukkan og Nóbelsverðlaunin í lífeðlis-og læknisfræði 2017Laeknabladid
Genomic regions controlling shape variation in the first upper molar of the house mouseeLife
KIT^D816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanomaMolecular Cancer Research

2015

Meningeal melanocytes in the mouseFrontiers in Neuroanatomy
Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1Journal of Cell Science
Tilfelli mánaðarins.Læknablaðið
Altered E-cadherin levels and distribution in melanocytes precede clinical manifestations of vitiligoJournal of Investigative Dermatology
MITF regulation - more hints from WntPigment Cell and Melanoma Research

2014

Selection, p53, and pigmentation.Pigment cell & melanoma research
Sun-induced frecklingPigment Cell and Melanoma Research

2013

XA polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathwayCell
MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein functionHuman Molecular Genetics
Differential activity of c-KIT splice forms is controlled by extracellular peptide insert lengthCellular Signalling
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traitsNature
Lífvísindasetur Háskóla ÍslandsLaeknabladid
Expression and Functional Role of Sprouty-2 in Breast MorphogenesisPLoS ONE

2012

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITFGenes and Development

2011

C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferationPLoS ONE

2010

A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1BMC Systems Biology
Interpretation of complex phenotypesPigment Cell and Melanoma Research
miR-148 regulates Mitf in melanoma cellsPLoS ONE

2009

Design and analysis of microarray experiments for pharmacogenomics
The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescueGenetics
Litfrumur og sortuæxliLaeknabladid

2008

Novel MITF targets identified using a two-step DNA microarray strategyPigment Cell and Melanoma Research
An unstable targeted allele of the mouse Mitf gene with a high somatic and germline reversion rateGenetics
All for one, one for allPigment Cell and Melanoma Research

2007

Statistically designing microarrays and microarray experiments to enhance sensitivity and specificityBriefings in Bioinformatics
Evolutionary sequence comparison of the Mitf gene reveals novel conserved domainsPigment Cell Research

2006

Umritunarþættir og stofnfrumur litfrumna.
Familial risk of colon and rectal cancer in IcelandInternational Journal of Cancer
The microphthalmia-associated transcription factor Mitf interacts with β-catenin to determine target gene expressionMolecular and Cellular Biology
A population-based study on the familial aggregation of cutaneous malignant melanoma in IcelandEuropean Journal of Cancer
Mouse coat color mutationsDevelopmental Dynamics
The effective size of the Icelandic population and the prospects for LD mappingEuropean Journal of Human Genetics

2005

Melanocyte stem cell maintenance and hair grayingCell
Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptorJournal of Immunology

2004

The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye developmentGenetics
The novel mouse microphthalmia mutations Mitf^mi-enu5 and Mitf^mi-bcc2 produce dominant negative Mitf proteinsGenomics
Electroretinographic assessment of retinal function in microphthalmia mutant miceExperimental Eye Research
BRCA2, but not BRCA1, mutations account for familial ovarian cancer in IcelandEuropean Journal of Cancer
Electroretinographic and histologic assessment of retinal function in Microphthalmia mutant miceExperimental Eye Research
Melanocytes and the Microphthalmia transcription factor networkAnnual Review of Genetics
The Icelandic Cancer Project - A population-wide approach to studying cancerNature Reviews Cancer

2003

Interallelic complementation at the mouse Mitf locusGenetics
Eiginleikar stofnfrumna : frumusérhæfing og ný meðferðarúrræði?Læknablaðið

2002

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast developmentProceedings of the National Academy of Sciences of the United States of America

2001

MODY in Iceland is associated with mutations in HNF-1α and a novel mutation in NeuroD1Diabetologia

2000

Genomic, transcriptional and mutational analysis of the mouse microphthalmia locusGenetics
CorrigendumEMBO Journal

1999

The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2Genomics
Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motifEMBO Journal

1998

Mitfmi-enu122 is a missense mutation in the HLH dimerization domain.Mammalian genome : official journal of the International Mammalian Genome Society
The bHLH-Zip transcription factor Tfeb is essential for placental vascularizationDevelopment

1997

NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectivelyGenomics
Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent geneGenome Research

1996

The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2Genomics
Mad3 and Mad4The EMBO journal
The semidominant Mi^b mutation identifies a role for the HLH domain in DNA binding in addition to its role in protein dimerizationEMBO Journal

1995

Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm developmentProceedings of the National Academy of Sciences of the United States of America
Mad3 and Mad4EMBO Journal
Posterior stripe expression of hunchback is driven from two promoters by a common enhancer elementDevelopment
Murine chromosomal location of five bHLH-Zip transcription factor genesGenomics
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell developmentDevelopment
Mild osteopetrosis in the microphthalmia-oak ridge mouseAmerican Journal of Pathology

1994

Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteinsOncogene
microphthalmia, A critical factor in melanocyte development, defines a discrete transcription factor familyGenes and Development
Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequencesNature Genetics
Genomic organization, alternative polyadenylation, and chromosomal localization of grg, a mouse gene related to the groucho transcript of the drosophila enhancer of split complexGenomics

1993

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper proteinCell
Characterization of downstream elements in a Raf-1 pathwayProceedings of the National Academy of Sciences of the United States of America

1992

Bicoid and the terminal system activate Tailless expression in the early Drosophila embryoDevelopment

1991

Dual role of the Drosophila pattern gene tailless in embryonic terminiScience

1990

The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamilyCell

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