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Forsíða

Eiríkur Steingrímsson - Professor

Eiríkur Steingrímsson

–

Heilbrigðisvísindasvið

Eiríkur Steingrímsson

Professor

Location
Sturlugata 8
Phone
525 - 4270
Email
eirikurs [at] hi.is

Unit
Biochemistry

Published works

2023

Hedgehog signalling in bone and osteoarthritis: the role of Smoothened and cholesterolThe FEBS Journal

2022

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genesPLOS Genetics

2021

User guide to MiT‐TFE isoforms and post‐translational modificationsPigment Cell & Melanoma Research
TFAP2 paralogs facilitate chromatin access for MITF at pigmentation genes but inhibit expression of cell-cell adhesion genes independently of MITF
Epigenetic regulation during melanocyte development and homeostasisExperimental Dermatology

2020

MITF and TFEB cross-regulation in melanoma cellsPLOS ONE
Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.Molecular cell

2019

The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function.Scientific reports
Distribution of mast cells within the mouse heart and its dependency on MitfMolecular Immunology
MITF has a central role in regulating starvation-induced autophagy in melanoma.Scientific reports
Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease.Cancer research

2018

A short isoform of ATG7 fails to lipidate LC3/GABARAP.Scientific reports
BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export.Proceedings of the National Academy of Sciences of the United States of America
Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma: An Icelandic population-based case-control study.Pharmacoepidemiology and drug safety
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.Nature genetics

2017

An eye on microphthalmiaPigment Cell & Melanoma Research
KITD816V Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma.Molecular cancer research : MCR
Genomic regions controlling shape variation in the first upper molar of the house mouseeLife

2015

Meningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf.Frontiers in neuroanatomy
MITF regulation - more hints from Wnt.Pigment cell & melanoma research
Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1.Journal of cell science
Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of Vitiligo.The Journal of investigative dermatology

2014

Sun-induced freckling: ephelides and solar lentigines.Pigment cell & melanoma research

2013

Selection, p53, and pigmentation.Pigment cell & melanoma research
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.Cell
Differential activity of c-KIT splice forms is controlled by extracellular peptide insert length.Cellular signalling
MITF mutations associated with pigment deficiency syndromes and melanoma have different effects on protein function.Human molecular genetics
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits.Nature
Expression and functional role of sprouty-2 in breast morphogenesis.PloS one

2012

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF.Genes & development

2011

C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation.PloS one

2010

Interpretation of complex phenotypes: lessons from the Mitf gene.Pigment cell & melanoma research
A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1.BMC systems biology
miR-148 regulates Mitf in melanoma cells.PloS one

2009

The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue.Genetics

2008

An unstable targeted allele of the mouse Mitf gene with a high somatic and germline reversion rate.Genetics
Novel MITF targets identified using a two-step DNA microarray strategy.Pigment cell & melanoma research
All for one, one for all: alternative promoters and Mitf.Pigment cell & melanoma research

2007

Evolutionary sequence comparison of the Mitf gene reveals novel conserved domains.Pigment cell research

2006

Mouse coat color mutations: from fancy mice to functional genomics.Developmental dynamics : an official publication of the American Association of Anatomists
A population-based study on the familial aggregation of cutaneous malignant melanoma in Iceland.European journal of cancer (Oxford, England : 1990)
Familial risk of colon and rectal cancer in Iceland: evidence for different etiologic factors?International journal of cancer
The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression.Molecular and cellular biology
Statistically designing microarrays and microarray experiments to enhance sensitivity and specificity.Briefings in bioinformatics
The effective size of the Icelandic population and the prospects for LD mapping: inference from unphased microsatellite markers.European journal of human genetics : EJHG

2005

Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor.Journal of immunology (Baltimore, Md. : 1950)
Melanocyte stem cell maintenance and hair graying.Cell

2004

The novel mouse microphthalmia mutations Mitfmi-enu5 and Mitfmi-bcc2 produce dominant negative Mitf proteins.Genomics
Electroretinographic assessment of retinal function in microphthalmia mutant mice.Experimental eye research
The Icelandic Cancer Project--a population-wide approach to studying cancer.Nature reviews. Cancer
The basic helix-loop-helix leucine zipper transcription factor Mitf is conserved in Drosophila and functions in eye development.Genetics
Melanocytes and the microphthalmia transcription factor network.Annual review of genetics
BRCA2, but not BRCA1, mutations account for familial ovarian cancer in Iceland: a population-based study.European journal of cancer (Oxford, England : 1990)

2003

Interallelic complementation at the mouse Mitf locus.Genetics

2002

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.Proceedings of the National Academy of Sciences of the United States of America

2001

MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1.Diabetologia

2000

Genomic, transcriptional and mutational analysis of the mouse microphthalmia locus.Genetics

1999

Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif.The EMBO journal
The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2.Genomics

1998

Mitfmi-enu122 is a missense mutation in the HLH dimerization domain.Mammalian genome : official journal of the International Mammalian Genome Society
The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.Development (Cambridge, England)

1997

Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.Genome research
NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively.Genomics

1996

The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2.Genomics
The semidominant Mi(b) mutation identifies a role for the HLH domain in DNA binding in addition to its role in protein dimerization.The EMBO journal
Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.The EMBO journal

1995

Murine chromosomal location of five bHLH-Zip transcription factor genes.Genomics
Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.Development (Cambridge, England)
Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element.Development (Cambridge, England)
Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.The EMBO journal
Mild osteopetrosis in the microphthalmia-oak ridge mouse. A model for intermediate autosomal recessive osteopetrosis in humans.The American journal of pathology
Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development.Proceedings of the National Academy of Sciences of the United States of America

1994

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.Genes & development
Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19.Oncogene
Genomic organization, alternative polyadenylation, and chromosomal localization of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.Genomics
Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences.Nature genetics

1993

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein.Cell
Characterization of downstream elements in a Raf-1 pathway.Proceedings of the National Academy of Sciences of the United States of America

1992

bicoid and the terminal system activate tailless expression in the early Drosophila embryo.Development (Cambridge, England)

1991

Dual role of the Drosophila pattern gene tailless in embryonic termini.Science (New York, N.Y.)

1990

The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily.Cell

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